Cationic and Anionic Substitutions in Hydroxyapatite

Cacciotti, Ilaria

doi:10.1007/978-3-319-09230-0_7-1

Cited by 42 publications

(62 citation statements)

References 461 publications

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“…Bioglass materials are highly bioactive and capable to react with biological fluid that leads to the formation of hydroxyl carbonate apatite layers on the bioactive glass (BG) surface . Hydroxyl apatite crystals readily bonds interfacially with collagen fibers, furthermore supporting osteoblasts . Bioglass (45S5) composition elicits class “A” bioactivity; hence, it has a tendency to interact with both soft and hard tissue as a result of osteoproduction and osteoconduction.…”

Section: Introductionmentioning

confidence: 99%

Effect of microwave and probe sonication processes on sol–gel‐derived bioactive glass and its structural and biocompatible investigations

2019

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This study is to investigate the effect of synthesis approaches on morphology, porosity, and biocompatibility of bioactive glass (BG). BG prepared through sol–gel approach was subsequently subjected to microwave and probe sonication techniques to investigate the structural and morphological effect. Hexagonal rod‐shaped morphology was obtained in sol–gel‐derived bioactive glass, whereas mesoporous particles and spherical‐shaped morphology were observed in probe‐sonicated and microwave‐assisted sol–gel approaches, respectively. The probe‐sonicated BG has mesopores with pore diameter of 14.7 nm, whereas surface porosity of 1.5 nm, and 3.5 nm for pure sol–gel and microwave‐assisted sol–gel fabricated BGs. Granular size, shape, and porosity have a significant role at the point of contact with cellular membrane. Therefore, we studied the biocompatibility with respect to morphology and porosity of the fabricated BGs. From this study, we observed that the BG prepared using probe sonication method controls the particle size, further it enhances the porosity that altogether improves the biocompatibility. © 2019 Wiley Periodicals, Inc. J Biomed Mater Res Part B: Appl Biomater 108B:143–155, 2020.

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Section: Introductionmentioning

confidence: 99%

Effect of microwave and probe sonication processes on sol–gel‐derived bioactive glass and its structural and biocompatible investigations

2019

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“…The release of Ca and P creates a supersaturated solution which then precipitates into amorphous calcium phosphate which then crystallizes in apatite (Cacciotti, ; Martin, Twyman, Qiu, Knowles, & Newport, ). Furthermore, the controlled release of Si, Ca, Na, P, and Nb species from the bioactive glass has been associated with the promotion of bioactivity, angiogenesis, osteostimulation, osteoconduction, and other important properties for bone regeneration (Hench et al, ; Hench & Jones, ; Jones, ; Jones et al, ).…”

Section: Resultsmentioning

confidence: 99%

In vitro and in vivo osteogenic potential of niobium‐doped 45S5 bioactive glass: A comparative study

et al. 2019

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In vitro and in vivo experiments were undertaken to evaluate the solubility, apatite‐forming ability, cytocompatibility, osteostimulation, and osteoinduction for a series of Nb‐containing bioactive glass (BGNb) derived from composition of 45S5 Bioglass. Inductively coupled plasma optical emission spectrometry (ICP‐OES) revealed that the rate at which Na, Ca, Si, P, and Nb species are leached from the glass decrease with the increasing concentration of the niobium oxide. The formation of apatite as a function of time in simulated body fluid was monitored by 31P Magic Angle Spinning (MAS) Nuclear magnetic resonance spectroscopy. Results showed that the bioactive glasses: Bioglass 45S5 (BG45S5) and 1 mol%‐Nb‐containing‐bioactive glass (BGSN1) were able to grow apatite layer on their surfaces within 3 h, while glasses with higher concentrations of Nb2O5 (2.5 and 5 mol%) took at least 12 h. Nb‐substituted glasses were shown to be compatible with bone marrow‐derived mesenchymal stem cells (BMMSCs). Moreover, the bioactive glass with 1 mol% Nb2O5 significantly enhanced cell proliferation after 4 days of treatment. Concentrations of 1 and 2.5 mol% Nb2O5 stimulated osteogenic differentiation of BMMSCs after 21 days of treatment. For the in vivo experiments, trial glass rods were implanted into circular defects in rat tibia in order to evaluate their osteoconductivity and osteostimulation. Two morphometric parameters were analyzed: (a) thickness of new‐formed bone layer and (b) area of new‐formed subperiostal bone. Results showed that BGNb bioactive glass is osteoconductive and osteostimulative. Therefore, these results indicate that Nb‐substituted glass is suitable for biomedical applications.

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“…Hence, the Se-HAP's synthesized in this study can be referred as selenite substituted carbonated HAP nanorods. It has been reported in the literature 5,6,16,24,47 that the size of the Se-HAP is larger than pure HAP and the morphology is changed from a spherelike to a needle-like structure. The EDS pattern of pure HAP reveals the presence of Ca, P and O while the presence of Se besides Ca, P and O is evident in Se-HAP ( Figure 7A-F).…”

Section: Morphological Characteristics Of Pure Hap and Se-hapmentioning

confidence: 94%

“…In recent years, many foreign ions were incorporated in trace levels, either in the HAP crystal lattice or adsorbed on the crystal surface and, such modifications have led to a significant influence on the stoichiometry, crystallinity, crystallite size, and morphological features of HAP. [3][4][5][6] The most common trace element or ionic moiety having a potential to improve physical, chemical, and biological properties upon incorporation in the HAP matrix are Mg 2+ , Zn 2+ , Sr 2+ , CO 2À 3 , F À , etc. [7][8][9][10][11][12][13][14][15] Incorporation of these elements plays a substantial role in improving the biological activity of the apatites and, the eventual bone formation and regeneration.…”

Section: Introductionmentioning

confidence: 99%

Crystalline selenite substituted carbonated hydroxyapatite nanorods: Synthesis, characterization, evaluation of bioactivity and cytotoxicity

Rajendran

Ravichandran

Nellaiappan

2016

Int J Applied Ceramic Tech

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Synthesis of pure and selenite substituted hydroxyapatites (HAP and Se-HAP with 0.02-0.10Se) by sol-gel method and evaluation of their morphological features, nature of functional groups, phase purity, in vitro bioactivity and cytotoxicity are addressed. Spectral studies confirm the incorporation of selenite into the HAP lattice, accompanied by an increase in CO 3 2-content to maintain the charge imbalance following replacement of P 5+ with Se 4+, thus making the formation of selenite substituted carbonated HAP. Selenite substitution in the HAP lattice has led to a higher crystallinity and increased the crystallite size. The morphology of HAP is changed from sphere to rod-like structure upon substitution by selenite and the size of the rod is increased with an increase in the selenite content.Among the Se-HAP's, a better in vitro bioactivity and cell viability are observed for 0.02Se-HAP and 0.04Se-HAP while the trend is reversed when the extent of selenite substitution becomes higher. role in improving the biological activity of the apatites and, the eventual bone formation and regeneration. Selenium is a vital micro-nutrient and one of the most essential elements required for many biological metabolisms. It plays an important role in the protein functions, induction of cancer cell apoptosis, proliferation, and differentiation of bone cells to improve bone health. It also exhibits good antibacterial property. [16][17][18][19][20] Thus, substitution of selenite in the HAP matrix is likely to improve biological functions. However, studies on selenite incorporated HAPs are rather limited. The biological influence of selenium on human system is dose dependant and hence the use of selenium beyond the tolerance level could lead to selenosis and toxicity to cellular environment. [21][22][23] Hence, it is imperative to optimize the concentration of selenite in HAP. In earlier reports, selenite-substituted HAP (Se-HAP) was synthesized by precipitation method. 16,17,24,25 Nevertheless, this method led to a decrease in crystallinity of Se-HAP and promoted agglomeration of crystals even at lower concentrations of selenite. Crystalline HAP's are known to improve biomineralization process (the bone like apatite formation) and hence, they serve as exceptional biomaterials. Moreover, orthopedic implant applications warrant the use of highly crystalline apatites due to their stability during the early stages of resorption process and their ability to increase the longevity of the coating. 26Among the various methods available for the synthesis of HAP, 27-33 the sol-gel method has received much attention owing to its inherent advantages such as high product purity, improved crystallinity, homogenous molecular mixing and, its ability to synthesize HAP's at relatively low temperatures. 34,35 The sol-gel method, which has not been attempted previously for the synthesis of Se-HAP is an ideal choice to prepare high pure crystalline apatites. 36-38The present study aims to synthesize Se-HAP's with varying precursor selenite co...

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Cationic and Anionic Substitutions in Hydroxyapatite

Cited by 42 publications

References 461 publications

Effect of microwave and probe sonication processes on sol–gel‐derived bioactive glass and its structural and biocompatible investigations

Effect of microwave and probe sonication processes on sol–gel‐derived bioactive glass and its structural and biocompatible investigations

In vitro and in vivo osteogenic potential of niobium‐doped 45S5 bioactive glass: A comparative study

Crystalline selenite substituted carbonated hydroxyapatite nanorods: Synthesis, characterization, evaluation of bioactivity and cytotoxicity

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