Cationic Chitosan/Pectin Polyelectrolyte Nanocapsules of Moxifloxacin as Novel Topical Management System for Bacterial Keratitis

Reimagining the Past: A Future for Antibiotic Drug Discovery in Ophthalmology

“…Novel delivery system Norfloxacin 33 Nanoparticles Moxifloxacin 34,35 Chitosan/pectin cationic polyelectrolyte nanocapsules; imprinted silicone hydrogel contact lenses Besifloxacin 37 Polymeric microneedle arrays face of financial pressures inherent to drug developmenthigh failure rates due to formulation constraints, toxicity, or narrow spectrum of activity-in favor of more lucrative therapeutic targets. 6 As such, in lieu of this cost-prohibitive approach, a more viable strategy of drug repurposing has emerged, breathing new life into already established drugs.…”

“…Another approach to revitalize current ophthalmic antimicrobial agents is reconsidering the delivery mechanism. For example, norfloxacin-loaded poly ( dl -lactide-co-glycolide) nanoparticles for the treatment of P. aeruginosa keratitis 33 and chitosan/pectin cationic polyelectrolyte nanocapsules loaded with moxifloxacin for the treatment of S. aureus keratitis 34 have both been shown to improve the drug residence time on the ocular surface and drug penetration into the cornea. Drug-eluting contact lenses also have the potential to improve bioavailability of antibiotics in the treatment of IK.…”

Exploiting residual cocoa biomass to extract advanced materials as building blocks for manufacturing nanoparticles aimed at alleviating formation-induced oxidative stress on human dermal fibroblasts

“…The area of peaks in the regions of 1780-1720 cm⁻¹ related to (COOH) and 1640-1600 cm⁻¹ to COO⁻ were used to calculate the esterification degree based on the following equation: 95% (A), T1.5 min 95% (A), T11.5 min 5% (A), T15 min 95% (A), T20 min 95% (A). The heated electrospray ionisation parameter was set at 2.5 kV, with vaporiser temperature of 275 °C, ion transfer tube temperature of 300°C, and gas flow rates as follows: sheath gas (35), aux gas (7), sweep gas (0). Both data sets were acquired using the Data-Dependent Analysis methodology with Thermo's AcquireX work package.…”

“…Buffer A (95/5 LC/MS-grade water/acetonitrile) and Buffer B (5/95 LC/MS-grade water/ acetonitrile) were used in a gradient: T0 95% (A), T1.5 min 95% (A), T11.5 min 5% (A), T15 min 95% (A), and T20 min 95% (A). The heated electrospray ionisation parameter was set at 2.5 kV, with a vaporiser temperature of 275 °C, an ion transfer tube temperature of 300 °C, and gas ow rates as follows: sheath gas (35), aux gas (7), and sweep gas (0). Both data sets were acquired using the data-dependent analysis methodology with the Thermo AcquireX work package.…”

“…Specifically, its polyelectrolyte properties have been harnessed for creating large microbeads in combination with chitosan (CH) reaching an average diameter of 120 µm. These microbeads were synthesised by injecting PEC solutions into a crosslinking bath followed by immersion in a CH bath 7 . CH is a non-toxic polycationic derivative of chitin, biodegradable and biocompatible 8 .…”