Cationic dextrin nanoparticles for effective intracellular delivery of cytochrome <i>C</i> in cancer therapy

Sarkar, Ankita; Sarkhel, Sanchita; Bisht, Deepali; Jaiswal, Amit

doi:10.1039/d3cb00090g

Cited by 3 publications

(1 citation statement)

References 49 publications

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“…Zwitterions, known for their hydrophilic nature and low interfacial energy, have been shown to be excellent options for preventing fouling in drug delivery systems ( 111 ). A significant obstacle to effective medication administration and killing tumor cells is the need for efficient uptake by tumor cells and escape from endosomes after the nanocarriers accumulate at tumor sites ( 133 ). Evidence shows that changing the surface charge of nanocarriers from negative to slightly positive after circulating in the blood can enhance cellular uptake through electrostatic interaction-mediated internalization.…”

Section: Application Of Antifouling Materials In Oncologymentioning

confidence: 99%

Current status, challenges and prospects of antifouling materials for oncology applications

Zhang,

Sun

2024

Front. Oncol.

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Targeted therapy has become crucial to modern translational science, offering a remedy to conventional drug delivery challenges. Conventional drug delivery systems encountered challenges related to solubility, prolonged release, and inadequate drug penetration at the target region, such as a tumor. Several formulations, such as liposomes, polymers, and dendrimers, have been successful in advancing to clinical trials with the goal of improving the drug’s pharmacokinetics and biodistribution. Various stealth coatings, including hydrophilic polymers such as PEG, chitosan, and polyacrylamides, can form a protective layer over nanoparticles, preventing aggregation, opsonization, and immune system detection. As a result, they are classified under the Generally Recognized as Safe (GRAS) category. Serum, a biological sample, has a complex composition. Non-specific adsorption of chemicals onto an electrode can lead to fouling, impacting the sensitivity and accuracy of focused diagnostics and therapies. Various anti-fouling materials and procedures have been developed to minimize the impact of fouling on specific diagnoses and therapies, leading to significant advancements in recent decades. This study provides a detailed analysis of current methodologies using surface modifications that leverage the antifouling properties of polymers, peptides, proteins, and cell membranes for advanced targeted diagnostics and therapy in cancer treatment. In conclusion, we examine the significant obstacles encountered by present technologies and the possible avenues for future study and development.

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Section: Application Of Antifouling Materials In Oncologymentioning

confidence: 99%

Current status, challenges and prospects of antifouling materials for oncology applications

Zhang,

Sun

2024

Front. Oncol.

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Vallaris solanacea induces mitochondrial mediated apoptosis in HL-60 human promyelocytic leukemia cells

Agrawal,

Saxena,

Agrawal

2024

Food and Chemical Toxicology

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Advancements in mitochondrial-targeted nanotherapeutics: overcoming biological obstacles and optimizing drug delivery

Li,

Wei

et al. 2024

Front. Immunol.

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In recent decades, nanotechnology has significantly advanced drug delivery systems, particularly in targeting subcellular organelles, thus opening new avenues for disease treatment. Mitochondria, critical for cellular energy and health, when dysfunctional, contribute to cancer, neurodegenerative diseases, and metabolic disorders. This has propelled the development of nanomedicines aimed at precise mitochondrial targeting to modulate their function, marking a research hotspot. This review delves into the recent advancements in mitochondrial-targeted nanotherapeutics, with a comprehensive focus on targeting strategies, nanocarrier designs, and their therapeutic applications. It emphasizes nanotechnology’s role in enhancing drug delivery by overcoming biological barriers and optimizing drug design for specific mitochondrial targeting. Strategies exploiting mitochondrial membrane potential differences and specific targeting ligands improve the delivery and mitochondrial accumulation of nanomedicines. The use of diverse nanocarriers, including liposomes, polymer nanoparticles, and inorganic nanoparticles, tailored for effective mitochondrial targeting, shows promise in anti-tumor and neurodegenerative treatments. The review addresses the challenges and future directions in mitochondrial targeting nanotherapy, highlighting the need for precision, reduced toxicity, and clinical validation. Mitochondrial targeting nanotherapy stands at the forefront of therapeutic strategies, offering innovative treatment perspectives. Ongoing innovation and research are crucial for developing more precise and effective treatment modalities.

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Cationic dextrin nanoparticles for effective intracellular delivery of cytochrome C in cancer therapy

Abstract: Intracellular protein delivery shows promise as a selective and specific approach to cancer therapy. However, a major challenge is posed by delivering proteins into cells due to their macromolecular nature...

Cited by 3 publications

References 49 publications

Current status, challenges and prospects of antifouling materials for oncology applications

Current status, challenges and prospects of antifouling materials for oncology applications

Vallaris solanacea induces mitochondrial mediated apoptosis in HL-60 human promyelocytic leukemia cells

Advancements in mitochondrial-targeted nanotherapeutics: overcoming biological obstacles and optimizing drug delivery

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