Cationic gemini surfactant properties, its potential as a promising bioapplication candidate, and strategies for improving its biocompatibility: A review

Ahmady, Azin Rashidy; Hosseinzadeh, Pakshid; Solouk, Atefeh; Akbari, Somaye; Szulc, Adrianna; Brycki, Bogumił

doi:10.1016/j.cis.2021.102581

Cited by 94 publications

(47 citation statements)

References 219 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Cationic surfactants have been extensively applied as antimicrobial agents in various fields due to their excellent bactericidal activities [ 62 , 63 , 64 ]. The cationic surfactants exert biological activity mainly by disrupting bacterial membranes via electrostatic and hydrophobic interaction, which further leads to cell lysis and bacterial death [ 65 , 66 ]. The cationic surfactants were once supposed to be impervious to resistance.…”

Section: Supramolecular Self-assembly Of Cationic Surfactants and Pol...mentioning

confidence: 99%

Combatting Antibiotic Resistance Using Supramolecular Assemblies

Guo

Yuan-yuan

et al. 2022

Pharmaceuticals

View full text Add to dashboard Cite

Antibiotic resistance has posed a great threat to human health. The emergence of antibiotic resistance has always outpaced the development of new antibiotics, and the investment in the development of new antibiotics is diminishing. Supramolecular self-assembly of the conventional antibacterial agents has been proved to be a promising and versatile strategy to tackle the serious problem of antibiotic resistance. In this review, the recent development of antibacterial agents based on supramolecular self-assembly strategies will be introduced.

show abstract

Section: Supramolecular Self-assembly Of Cationic Surfactants and Pol...mentioning

confidence: 99%

Combatting Antibiotic Resistance Using Supramolecular Assemblies

Guo

Yuan-yuan

et al. 2022

Pharmaceuticals

View full text Add to dashboard Cite

show abstract

“…Найперспективнішими щодо антимікробної дії вважаються катіонні поверхнево-активні речовини, оскільки порівняно з іншими ПАР вони мають найвищу бактерицидну активність [5,6]. Окрім того, катіонні ПАР є неагресивними, леткими, не мають смаку й запаху, стійкі під час зберігання, мають нейтральні значення рН і добре поєднуються з багатьма хімічними речовинами.…”

Section: вступunclassified

“…Водночас широке використання катіонних ПАР призвело до значного накопичення їх у довкіллі, тим самим провокуючи формування стійкості в бактерій. Зважаючи на це, постійна увага спрямована на те, як раціонально розробити поверхнево-активні речовини для досягнення високоефективної антимікробної активності за менших концентрацій [5,6].…”

Section: вступunclassified

Antimicrobial activity of traditional and newly synthetized surface-active agents as a basis for the creation of new disinfectants

Furtat

Nechypurenko²,

Vakuliuk³

et al. 2022

NRPBE

View full text Add to dashboard Cite

Aim. The main goal of the study was to investigate the antibacterial and fungicidal properties of the traditional and newly synthesized surfactants of different classes, compare the analysis of their antimicrobial activity and find out the prospects for further use for the creation of disinfectants. Methods. The biocidal activity of the studied cationic, anionic and nonionic surfactants was determined in relation to representatives of the species Escherichia coli, Salmonella typhimurium, Staphylococcus aureus, as well as fungi Candida albicans. The detection of antibacterial and fungicidal effect and determination of minimum inhibitory concentrations (MIC) was carried out by cultivation of the test cultures of microorganisms in Nutrient Broth (NB, Himedia, India) for 24–48 hours at 37 °С in the presence of different concentrations of experimental surfactants (1000–0.1 ppm). The number of cells that remained viable after exposure to surfactants was determined by optical density in McFarland units, which were then converted to the number of cells in 1 ml using the standard McFarland scale. Results. The newly synthesized guanidine-containing oligomer at concentrations of 1000 and 100 ppm inhibited the growth of all test cultures without exception by 100 %. The biocidal effect on the representatives of various taxonomic groups of microorganisms differed in its effectiveness for various anionic surfactants (trilon B, surfactant 2 and surfactant 3) even at the highest concentration of 1000 ppm. In particular, only trilon B completely inhibited the growth of all test cultures. However, at the concentrations indicated above, the examined cationic (surfactant 1 and triethanolamine) and nonionic (OP-10 and triton X-100) exhibited a rather low antimicrobial activity. Conclusions. The results obtained indicate that the guanidine-containing oligomer exhibited the highest antimicrobial activity among the investigated surfactants. Therefore, it can be considered a promising surfactant for further use in the creation of broad-spectrum antimicrobial agents. Enhancement of the biocidal effect of newly created disinfectants can be implemented by introducing the studied anionic and nonionic detergents, and glutaraldehyde can be used to stabilize them or enhance their antimicrobial activity. Instead, the application of cationic surfactants used in the work is impractical.

show abstract

“…A promising approach in the development of amphiphilic systems for biomedical applications is the creation of new cationic surfactants that meet green chemistry criteria. , Biocompatible surfactants containing various natural fragments (sugar, amino acids, pyrimidine, and imidazolium) in the headgroup are promising building blocks for the formation of various types of nanocontainers . They provide an extended range of intermolecular (hydrogen bonds and electrostatic and van der Waals interactions), stacking, and complementary interactions during self-assembly, thereby combining high efficiency with lower toxicity .…”

Section: Introductionmentioning

confidence: 99%

Cationic Imidazolium Amphiphiles Bearing a Methoxyphenyl Fragment: Synthesis, Self-Assembly Behavior, and Antimicrobial Activity

et al. 2022

View full text Add to dashboard Cite

Novel cationic amphiphiles of the 3-alkyl-1-(4methoxyphenyl)-1H-imidazol-3-ium bromide series bearing methoxyphenyl fragments (MPI-n) have been synthesized. Their aggregation properties in aqueous solutions, solubilization capacity, and hemolytic and antimicrobial activities have been investigated by a number of physicochemical methods. Using tensiometry, conductometry, and fluorescence spectroscopy, it was shown that the MPI-n have lower CMCs than their nonfunctionalized counterparts. The unusual alkyl-chain-length-dependent morphology of aggregates is testified for this homological series. Amphiphiles with 12, 14, and 16 alkyl tails are characterized by the formation of micellar aggregates, while a surfactant with a decyl tail is characterized by the formation of larger aggregates with lower surface curvature. The MPI-10 aggregate morphology was rationalized in terms of the packing parameter consideration and was supported by size measurements and the fluorescence probe techniques, which showed that vesicle-like aggregates in closepacking mode probably occur. MPI-n aggregates have exhibited a high solubilization capacity toward hydrophobic azo dye Orange OT. Importantly, amphiphiles studied showed (i) high bacteriostatic activity at the level of ciprofloxacin; (ii) high bactericidal action against all Gram-positive bacteria, including methicillin-resistant strains; (iii) bactericidal properties against Gram-negative bacteria; and (iv) low hemolytic activity.

show abstract

Cationic gemini surfactant properties, its potential as a promising bioapplication candidate, and strategies for improving its biocompatibility: A review

Cited by 94 publications

References 219 publications

Combatting Antibiotic Resistance Using Supramolecular Assemblies

Combatting Antibiotic Resistance Using Supramolecular Assemblies

Antimicrobial activity of traditional and newly synthetized surface-active agents as a basis for the creation of new disinfectants

Cationic Imidazolium Amphiphiles Bearing a Methoxyphenyl Fragment: Synthesis, Self-Assembly Behavior, and Antimicrobial Activity

Contact Info

Product

Resources

About