2006
DOI: 10.1016/j.coi.2005.11.004
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Cationic host defense (antimicrobial) peptides

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Cited by 756 publications
(526 citation statements)
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References 85 publications
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“…2). (RW) 5 , interestingly, reveals large differences between water and both lipids. The presence of additional tryptophan side chains in the same molecule may affect the CD signal nonlinearly, and so these data cannot be interpreted more quantitatively.…”
Section: Resultsmentioning
confidence: 99%
See 3 more Smart Citations
“…2). (RW) 5 , interestingly, reveals large differences between water and both lipids. The presence of additional tryptophan side chains in the same molecule may affect the CD signal nonlinearly, and so these data cannot be interpreted more quantitatively.…”
Section: Resultsmentioning
confidence: 99%
“…The chain length of the (RW) n peptides strongly correlates with antibacterial activity assayed by growth inhibition and colony formation: peptides with longer chains are much more effective in killing bacteria but increasingly stimulate hemolytic activity. The (RW) 3 , (RW) 4 , and (RW) 5 peptides are potent antimicrobial agents, with all IC 50 s roughly in the M range. Selectivity is measured by hemolytic index, defined as the ratio of HD 50 to IC 50 .…”
Section: Resultsmentioning
confidence: 99%
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“…Cationic antimicrobial peptides (CAPs) have attracted interest as potential substitutes for conventional antibiotics to which many pathogens have acquired resistance [1][2][3]. Most CAPs are cationic by virtue of the presence of lysine, arginine and/or histidine and usually composed of 12-50 amino acids.…”
Section: Introductionmentioning
confidence: 99%