Cationic nanocapsule suspension as an alternative to the sublingual delivery of nifedipine

Osmari, Bárbara Felin; Medeiros, Giovana Aime; Reolon, Jéssica Brandão; Prado, Vinicius Costa; Brucker, Natália; Cruz, Letícia

doi:10.1080/10837450.2023.2203201

Pharmaceutical Development and Technology

2023

DOI: 10.1080/10837450.2023.2203201

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Cationic nanocapsule suspension as an alternative to the sublingual delivery of nifedipine

Bárbara Felin Osmari

Giovana Aime Medeiros

Jéssica Brandão Reolon

et al.

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Cited by 2 publications

References 61 publications

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Pomegranate oil-based nanocapsules enhance 3,3’-diindolylmethane action against melanoma cells

Reolon,

Merg,

Oliveira

et al. 2024

Braz. J. Pharm. Sci.

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Pomegranate oil-based nanocapsules enhance 3,3’-diindolylmethane action against melanoma cells

Reolon,

Merg,

Oliveira

et al. 2024

Braz. J. Pharm. Sci.

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In Situ Gelling Dexamethasone Oromucosal Formulation: Physical Characteristics Influencing Drug Delivery

Krchňák,

Balážová,

Hanko

et al. 2025

Gels

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The study focuses on the development of an in situ gelling dexamethasone (DEX) oromucosal formulation designed for the treatment of aphthous stomatitis. Three series of formulations were prepared; a first series containing DEX suspended, a second series containing DEX and, in addition, mint essential oil (EO), and a third series containing EO and DEX solubilized in propylene glycol (PG). In the composition, polymers in the role of mucoadhesive agent were interchanged (hydroxypropyl methylcellulose (HPMC), hydroxypropyl cellulose (HPC), hydroxyethyl cellulose (HEC), methyl cellulose (MC), carboxymethyl cellulose (CMC), and sodium carboxymethyl cellulose (NaCMC). Specifically, DEX was incorporated at a concentration of 0.1% (w/w) in each formulation. The influence of mint EO and DEX solubilization on the physical properties (pH measurements, rheological analysis, swelling ability, and texture analysis) and in vitro drug release was studied. Key findings revealed that HPMC-based formulation containing mint EO and PG exhibited best swelling properties (700 ± 46% after 5 h), adequate adhesiveness and in vitro drug release (34.7 ± 5.9%). Furthermore, the irritation potential assessed via the hen’s egg test on the chorioallantoic membrane (HET-CAM) demonstrated low irritancy risk. Finally, Fourier-transform infrared spectroscopy (FT-IR) showed no incompatibility between DEX and excipients. Overall, the research highlights the potential of mucoadhesive systems in improving the therapeutic efficacy of oromucosal drug delivery for managing painful oral lesions.

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Cationic nanocapsule suspension as an alternative to the sublingual delivery of nifedipine

Cited by 2 publications

References 61 publications

Pomegranate oil-based nanocapsules enhance 3,3’-diindolylmethane action against melanoma cells

Pomegranate oil-based nanocapsules enhance 3,3’-diindolylmethane action against melanoma cells

In Situ Gelling Dexamethasone Oromucosal Formulation: Physical Characteristics Influencing Drug Delivery

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