Cationic Polyelectrolytes as Drug Delivery Vectors: Calorimetric and Fluorescence Study of Rutin Partitioning

Bai, Guangyue; Nichifor, Marieta; Bastos, Margarida

doi:10.1021/jp1071555

Cited by 28 publications

(11 citation statements)

References 58 publications

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“…Mixtures of polymers and surfactants are used in a variety of applications, such as drug delivery [ 1 , 2 , 3 ], oil recovery [ 4 ], cosmetics, and more [ 5 , 6 ]. In general, the mixtures of polymers and surfactants are used to control the rheology of the solution, and to manipulate surface adsorption of the surfactant.…”

Section: Introductionmentioning

confidence: 99%

Investigation of Surfactant-Polymer Interactions Using Rheology and Surface Tension Measurements

Yang

Pal

2020

Polymers

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The interactions between surfactants and a drag-reducing polymer were investigated at a low polymer concentration of 500 ppm, using measurements of the rheology and surface activity of surfactant-polymer solutions. A well-known drag-reducing polymer (anionic sodium carboxymethyl cellulose) and five different surfactants (two anionic, two non-ionic, and one zwitterionic) were selected for the interaction studies. The surfactant-polymer solutions were shear thinning in nature, and they followed the power law model. The interaction between the surfactant and polymer had a strong effect on the consistency index of the solution and a marginal effect on the flow behavior index. The surface tension versus surfactant concentration plots were interpreted in terms of the interactions between surfactant and polymer. The critical aggregation concentration (CAC) of the surfactant was estimated based on the surface tension and rheological data. The CAC values of the same charge surfactants as that of the polymer were found to be significantly higher than other combinations of surfactant and polymer, such as non-ionic surfactant/anionic polymer, and zwitterionic surfactant/anionic polymer.

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Section: Introductionmentioning

confidence: 99%

Investigation of Surfactant-Polymer Interactions Using Rheology and Surface Tension Measurements

Yang

Pal

2020

Polymers

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“…Hydrophobically modified water-soluble polymers (HM polymers) have amphiphilic properties in aqueous solutions because they contain both hydrophobic and hydrophilic moieties. − Despite the degree of substitution often being lower than 5 mol %, they often have superior performance with respect to their unmodified relatives. In particular, mixtures of HM polymers with surfactants in aqueous solution give rise to the formation of associated structures that can modify solution and interfacial properties in ways that are interesting for both fundamental and applied purposes. − Hydrophobic and electrostatic interactions both contribute to the driving force for the association of surfactant/HM polymer mixtures in aqueous solution, leading to intricate phase behavior and rich self-assembling morphologies.…”

Section: Introductionmentioning

confidence: 99%

Self-Assembled Structures of Anionic Hydrophobically Modified Polyacrylamide with Star-Shaped Trimeric and Hexameric Quaternary Ammonium Surfactants

Fan

Wang

et al. 2014

Langmuir

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The self-assembly of a 1% hydrophobically modified and 30% hydrolyzed polyacrylamide (C12PAM) with cationic star-shaped oligomeric surfactants has been investigated by isothermal titration microcalorimetry, turbidimetry, ζ potential, scanning electron microscopy, and (1)H NMR techniques. The oligomeric surfactants are composed of quaternary dodecyldimethylammonium ions with three or six hydrophobic chains connected by a polyamine spacer at the headgroup level, abbreviated as DTAD and PAHB, respectively. DTAD/C12PAM and PAHB/C12PAM mixed systems undergo the same aggregate transitions with increases in surfactant concentration from soluble networklike aggregates to precipitated denser and more cross-linked structures and then to soluble spherical aggregates. The networklike aggregates are generated at very low surfactant concentration. However, at the corresponding surfactant concentration without C12PAM, DTAD cannot form aggregates and PAHB forms only networklike aggregates with a very loose structure. The strong electrostatic and hydrophobic interaction of DTAD and PAHB with C12PAM and the hydrophobic interaction between the alkyl chains of DTAD and PAHB themselves evidently promote the formation of networklike aggregates. As the surfactant concentration increases, cationic surfactants become excessive. The molecular configuration is changed by the stronger hydrophobic association among the DTAD and PAHB molecules and the enhanced electrostatic repulsion between the mixed aggregates. Thus, the networklike aggregates transfer to spherical aggregates.

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“…A number of studies have been published on the interactions between polymers and surfactants (Harada and Kataoka, 2006;Dan et al, 2009;Bai et al, 2010;Stoll et al, 2010;Villetti et al, 2011;Zhang et al, 2011). The majority of these studies are focused on the methodology and the feasibility to accomplish polymer-surfactant aggregation at very low surfactant concentrations (Goddard and Ananthapadmanabhan, 1993;Kwak, 1998;Touhami et al, 2001;Trabelsi and Langevin, 2007).…”

Section: Introductionmentioning

confidence: 99%

Effect of cationic surfactant addition on the drag reduction behaviour of anionic polymer solutions

2011

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Although extensive research work has been carried out on the drag reduction (DR) behaviour of polymers and surfactants alone, little progress has been made on the synergistic effects of combined polymers and surfactants. In this work, the interactions between drag-reducing anionic polymer (copolymer of acrylamide and sodium acrylate, referred to as PAM) and drag-reducing cationic surfactant (octadecyltrimethylammonium chloride, OTAC) are studied. Solutions are prepared using both deionised (DI) water and tap water. The measurement of the physical properties such as electrical conductivity and viscosity are used to determine the surfactant-polymer interactions. The addition of surfactant to the polymer solution has a significant effect on the properties of the system. The critical micelle concentration (CMC) of the mixed surfactant-polymer system is found to be different from that of the surfactant alone. With the addition of surfactant to a polymer solution, a substantial decrease in the viscosity occurs. The observed changes in the viscosity of mixed polymer-surfactant system are explained in terms of the changes in the extension of polymeric chains, resulting from polymer-surfactant interactions. The anionic PAM chains tend to collapse upon the addition of cationic OTAC. The pipeline flow behaviour of PAM/OTAC mixtures is found to be consistent with the bench scale results. The DR ability of PAM is reduced upon the addition of OTAC. At low concentrations of PAM, the effect of OTAC on the DR behaviour is more pronounced. The DR behaviour of polymer solutions is strongly influenced by the nature of water (DI or tap).

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Cationic Polyelectrolytes as Drug Delivery Vectors: Calorimetric and Fluorescence Study of Rutin Partitioning

Cited by 28 publications

References 58 publications

Investigation of Surfactant-Polymer Interactions Using Rheology and Surface Tension Measurements

Investigation of Surfactant-Polymer Interactions Using Rheology and Surface Tension Measurements

Self-Assembled Structures of Anionic Hydrophobically Modified Polyacrylamide with Star-Shaped Trimeric and Hexameric Quaternary Ammonium Surfactants

Effect of cationic surfactant addition on the drag reduction behaviour of anionic polymer solutions

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