Cationic quaternized chitosan bioconjugates with aggregation-induced emission features for cell imaging

Qiao, Fenghui; Ke, Jia-han; Pei, Boying; Hu, Qiaoling; Tang, Ben Zhong; Wang, Zhengke

doi:10.1016/j.carbpol.2019.115614

Cited by 17 publications

(12 citation statements)

References 42 publications

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“…Owing to its large specific surface area and π-conjugated structure, and significant surface activity deriving from abundant oxygen-containing functional groups, GO nanocarriers can load a mass of drugs ( Wang et al., 2018a ). CS, as a natural cationic polyelectrolyte, will be positively charged when encountering an acidic extracellular medium of solid tumors, which is very helpful for cellular uptake because nanocarriers with a positive charge are more attracted to negatively charged tumor cell membranes ( Qiao et al., 2020 ; Yang et al., 2019b ; Zhao et al., 2018 ). As a consequence, nanocomposites based on CS and GO are often used to efficiently immobilize or load antitumor drugs and biomacromolecules for controlled delivery and long-term sustained release.…”

Section: Drug and Biomacromolecules Deliverymentioning

confidence: 99%

Biomedical applications of chitosan-graphene oxide nanocomposites

Feng¹,

Wang²

2022

iScience

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Summary Chitosan (CS) and graphene oxide (GO) nanocomposites have received wide attention in biomedical fields due to the synergistic effect between CS which has excellent biological characteristics and GO which owns great physicochemical, mechanical, and optical properties. Nanocomposites based on CS and GO can be fabricated into a variety of forms, such as nanoparticles, hydrogels, scaffolds, films, and nanofibers . Thanks to the ease of functionalization, the performance of these nanocomposites in different forms can be further improved by introducing other functional polymers, nanoparticles, or growth factors. With this background, the current review summarizes the latest developments of CS–GO nanocomposites in different forms and compositions in biomedical applications including drug and biomacromolecules delivery, wound healing, bone tissue engineering, and biosensors. Future improving directions and challenges for clinical practice are proposed as well.

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Section: Drug and Biomacromolecules Deliverymentioning

confidence: 99%

Biomedical applications of chitosan-graphene oxide nanocomposites

Feng¹,

Wang²

2022

iScience

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“…As a result, the cationic CS, or the quaternized chitosan (QCS), has recently found applications in the preparation of various materials, ranging from daily life (for instances, agriculture, water and waste, food and beverages treatment, cosmetics and toiletries) to advanced research (e.g., in biopharmaceutical and biomedical fields) [10][11][12]. One of the most promising applications is to utilize the intrinsic property of CS or QCS as matrixes in the fabrication of drug delivery nanocarriers [13][14][15][16][17][18]. Generally, drug delivery nanocarriers have recently garnered huge attention in many scientific branches [19].…”

Section: Introductionmentioning

confidence: 99%

Dually Responsive Nanoparticles for Drug Delivery Based on Quaternized Chitosan

Qiao

Jiang

Fang

et al. 2022

IJMS

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In this work, we report the fabrication and functional demonstration of a kind of dually responsive nanoparticles (NPs) as a potential drug delivery vector. The pH value, corresponding to the acidic microenvironment at the tumor site, and mannitol, to the extracellular trigger agent, were employed as the dually responsive factors. The function of dual responses was achieved by breaking the dynamic covalent bonds between phenylboronic acid (PBA) groups and diols at low pH value (pH 5.0) and/or under the administration of mannitol, which triggered the decomposition of the complex NPs and the concomitant release of anticancer drug of doxorubicin (DOX) loaded inside the NPs. The NPs were composed of modified chitosan (PQCS) with quaternary ammonium and PBA groups on the side chains, heparin (Hep), and poly(vinyl alcohol) (PVA), in which quaternary ammonium groups offer the positive charge for the cell-internalization of NPs, PBA groups serve for the formation of dynamic bonds in responding to pH change and mannitol addition, PVA furnishes the NPs with diol groups for the interaction with PBA groups and the formation of dynamic NPS, and Hep plays the roles of reducing the cytotoxicity of highly positively-charged chitosan and forming of complex NPs for DOX up-loading. A three-step fabrication process of drug-loaded NPs was described, and the characterization results were comprehensively demonstrated. The sustained drug release from the drug-loaded NPs displayed obvious pH and mannitol dependence. More specifically, the cumulative DOX release was increased more than 1.5-fold at pH 5.0 with 20 mg mL−1 mannitol. Furthermore, the nanoparticles were manifested with effective antitumor efficient and apparently enhanced cytotoxicity in response to the acidic pH value and/or mannitol.

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“…A number of efforts have been devoted to enhance the water solubility of CS derivatives via the reactions with NH 2 and OH functional groups of CS. As result quaternized CS (QCS), 56 carboxymethyl CS, 57 N ‐gluconic acid CS, 58 and CS‐catechol conjugate 59 were obtained, and on reaction with acetic anhydride resulted N‐acetylated CS 60,61 . Table 1 illustrates some of the reports carried out in this field.…”

Section: Resultsmentioning

confidence: 99%

Synthesis and wound healing performance of new water‐soluble chitosan derivatives

Shahzadi

Jamal

Hajivand

et al. 2021

J of Applied Polymer Sci

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In present work, an efficient method for the preparation of water‐soluble chitosan (CS) is reported. It is based on simple synthetic method, which is easy to handle and delivered good water solubility. This article describes the effect of various factors such as the concentration of reactants and the amount of solvents on the reactions' outcome as well as cytocompatibility of the resulting water‐soluble CS derivatives. CS derivatives with different ratios of polyethyleneimine (PEI) (80:20 (CP1), 90:20 (CP2), 95:5 (CP3), 99:1 (CP4), and 99.6:0.4 [CP5]), at optimized conditions (50 g of CS, 1 L of 0.5 M acetic acid solution at 80°C for 24 h) were synthesized. It was noted that the amount of PEI was critical for the cytocompatibility, decreasing the amount of PEI led to increasing the cytocompatibility of the obtained water soluble CS derivatives. To show the biomedical and drug delivery applications of the newly synthesized CS derivative, this was used to prepare membranes by freeze‐drying and was loaded with thyroxine, respectively. The angiogenic potential of the thyroxine loaded membranes was tested in chorio allantoic membrane assay, which showed good level of neovascularization. For wound healing studies full thickness wounds rat model was used and thyroxine loaded hydrogels showed complete wound healing at day 23.

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Cationic quaternized chitosan bioconjugates with aggregation-induced emission features for cell imaging

Cited by 17 publications

References 42 publications

Biomedical applications of chitosan-graphene oxide nanocomposites

Biomedical applications of chitosan-graphene oxide nanocomposites

Dually Responsive Nanoparticles for Drug Delivery Based on Quaternized Chitosan

Synthesis and wound healing performance of new water‐soluble chitosan derivatives

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