Cationic solid lipid nanoparticles for co-delivery of paclitaxel and siRNA

Yu, Yong H.; Kim, Eunjoong; Park, Dai Eui; Shim, Gayong; Lee, Sangbin; Kim, Young Bong; Kim, Chan Wha; Oh, Yu‐Kyoung

doi:10.1016/j.ejpb.2011.11.002

Cited by 138 publications

(57 citation statements)

References 24 publications

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“…In the past decades, targeted drug delivery strategies for cancer therapy have emerged as a most promising technology platform to overcome these problems [4,5]. Up until now, a large number of drug delivery systems, such as synthetic polymer-drug conjugates [6], liposomes [7], nanomicelles [8], nanogels [9], quantum dots [10] and nanoparticles [11], have been extensively investigated for targeted intracellular delivery of chemotherapeutics. These delivery systems offer several advantages, such as (i) increasing the water solubility of hydrophobic drugs, (ii) protecting drugs from aggregation, degradation and/or deactivation, (iii) enhancing drug bioavailability, (iv) prolonging blood circulation time and (v) enabling passive or active targeting of drugs to the tumor tissues and cells [12].…”

Section: Introductionmentioning

confidence: 99%

Stimuli-responsive PEGylated prodrugs for targeted doxorubicin delivery

Qian

Liu

et al. 2015

Materials Science and Engineering: C

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Section: Introductionmentioning

confidence: 99%

Stimuli-responsive PEGylated prodrugs for targeted doxorubicin delivery

Qian

Liu

et al. 2015

Materials Science and Engineering: C

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“…They improve tissue distribution leading to enhancement of bioavailability of entrapped actives [11]. Researchers have reported that targeting of drugs to specific organs can be possible with SLN and NLC [12][13][14].…”

Section: Introductionmentioning

confidence: 99%

Characterization and Imaging of Solid Lipid Nanoparticles and Nanostructured Lipid Carriers

Üner¹

2015

Handbook of Nanoparticles

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KeywordsAtomic force microscopy; Differential scanning calorimetry; Dynamic light scattering; Fourier transform infrared spectroscopy; Low angle laser light scattering; Nanostructured lipid carriers; Proton nuclear magnetic resonance spectroscopy; Raman spectroscopy; Scanning electron microscopy; Solid lipid nanoparticles; Transmission electron microscopy; X-ray scattering Solid lipid nanoparticles (SLN) and nanostructured lipid carriers (NLC), the second generation of SLN, are colloidal drug carrier systems that can be used for controlled drug delivery via various administration routes. They introduce various advantages over traditional dosage forms and their colloidal counterparts. SLN and NLC products are available in the market of the European community, and lipid nanotechnology has been increasingly attracted by the industry. Moreover, studies on lipid nanoparticles have been focused on targeting of drugs to the specific sites of the body, thus surface modification and treatment of SLN and NLC in the last decades. Naturally, several parameters must be taken into consideration for design of well-performing formulations, which have a long-term stability. A lot of analytical methods, which give scientists extensive informations, are essential for characterization of SLN and NL-C. Investigation of factors affecting their physicochemical properties and common techniques used for their characterization will be introduced in this chapter. Determination methods of particle size, particle charge, and surface characteristics, crystallographic and structural investigations, and imaging of SLN and NLC will be discussed. In vivo and in vitro experiments will also be summarized to describe future direction of researches.

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“…23 They have advantages such as less toxicity, low immunogenicity, and being easily modified, and our previous studies mainly focused on the development of SLNs. 24,25 A problem related to SLN is low drug encapsulation and increased drug expulsion during storage because of the recrystallization process.…”

Section: Han Et Almentioning

confidence: 99%

“…23 Blank SLN was prepared following the solvent displacement method. For the organic phase preparation, stearic acid (50 mg), injectable soya lecithin (30 mg), and DOX base were dissolved in 10 mL of acetone.…”

Section: Preparation Of Nlcmentioning

confidence: 99%

Transferrin-modified nanostructured lipid carriers as multifunctional nanomedicine for codelivery of DNA and doxorubicin

Han¹,

Zhang²,

Li³

et al. 2014

IJN

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Background Nanostructured lipid carriers (NLC), composed of solid and liquid lipids, and surfactants are potentially good colloidal drug carriers. The aim of this study was to develop surface-modified NLC as multifunctional nanomedicine for codelivery of enhanced green fluorescence protein plasmid (pEGFP) and doxorubicin (DOX). Methods Two different nanocarriers: pEGFP- and DOX-loaded NLC, and solid lipid nanoparticles (SLN) were prepared. Transferrin-containing ligands were used for the surface coating of the vectors. Their average size, zeta potential, and drug encapsulation capacity were evaluated. In vitro transfection efficiency of the modified vectors was evaluated in human alveolar adenocarcinoma cell line (A549 cells), and in vivo transfection efficiency of the modified vectors was evaluated in a mouse bearing A549 cells model. Results Transferrin-modified DOX and pEGFP coencapsulated NLC (T-NLC) has a particle size of 198 nm and a +19 mV surface charge. The in vitro cell viabilities of the T-NLC formulations were over 80% compared with the control. T-NLC displayed remarkably greater gene transfection efficiency and enhanced antitumor activity than DOX- and pEGFP-coencapsulated SLN in vivo. Conclusion The results demonstrate that T-NLC noticeably enhanced antitumor activity through the combination of gene therapy with chemotherapy. Also coating of active transferrin improved the lung cancer cell-targeting of the carriers. In summary, the novel gene and drug delivery system offers a promising strategy for the treatment of lung cancer.

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Cationic solid lipid nanoparticles for co-delivery of paclitaxel and siRNA

Cited by 138 publications

References 24 publications

Stimuli-responsive PEGylated prodrugs for targeted doxorubicin delivery

Stimuli-responsive PEGylated prodrugs for targeted doxorubicin delivery

Characterization and Imaging of Solid Lipid Nanoparticles and Nanostructured Lipid Carriers

Transferrin-modified nanostructured lipid carriers as multifunctional nanomedicine for codelivery of DNA and doxorubicin

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