Cationic synthetic long peptides-loaded nanogels: An efficient therapeutic vaccine formulation for induction of T-cell responses

Kordalivand, Neda; Tondini, Elena; Lau, Chun Yin; Vermonden, Tina; Mastrobattista, Enrico; Hennink, Wim E.; Ossendorp, Ferry; Nostrum, Cornelus F. van

doi:10.1016/j.jconrel.2019.10.048

Cited by 37 publications

(34 citation statements)

References 70 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…large specific surface area for payload delivery, enhanced bioavailability of the payloads, and multiple surface functionalization) [ 192 ]. There are several ways to form nanogels, including (i) self-assembly [ 60 , 121 , [193] , [194] , [195] , [196] , [197] ]; (ii) emulsion polymerization [ 198 , 199 ]; and (iii) particle replication in nonwetting template (PRINT) technology [ 200 ]. Synthetic polymers [ 121 , 193 , 195 , 200 ], polysaccharides [ 60 , [196] , [197] , [198] , [199] ] and their combination [ 201 ] have been developed to form nanogels for vaccine applications.…”

Section: Immunological Basis For Particulate Vaccine Deliverymentioning

confidence: 99%

“…Nanogels can also be formed using polysaccharides like dextran [ 198 , 199 ], alginate [ 197 ], and cholesterol-bearing pullulan and dextran [ 60 , 196 ]. Most polysaccharide based nanogels have been recently developed in efforts to achieve effective intracellular delivery potential for cancer vaccines [ 60 , [196] , [197] , [198] , [199] ]. Shen et al synthesized and developed sub-200 nm alginate nanogels as an oral DNA vaccine by loading with Tat peptide and gp100 encoding plasmid DNA through electrostatic interactions [ 197 ].…”

Section: Immunological Basis For Particulate Vaccine Deliverymentioning

confidence: 99%

See 1 more Smart Citation

Polymeric nanoparticle vaccines to combat emerging and pandemic threats

et al. 2021

View full text Add to dashboard Cite

Section: Immunological Basis For Particulate Vaccine Deliverymentioning

confidence: 99%

Section: Immunological Basis For Particulate Vaccine Deliverymentioning

confidence: 99%

Polymeric nanoparticle vaccines to combat emerging and pandemic threats

et al. 2021

View full text Add to dashboard Cite

“…Further co‐encapsulation of poly I: C, a TLR3 agonist in this nanogel, augmented CD8 + T cell‐mediated immune response and helped in the efficient eradication of tumors from the mice. [ 89 ] To integrate the chemoimmunotherapy, Chen's group developed a nanogel delivery platform from FDA approved polyvinyl alcohol and vinyl ether acrylate and used for dual encapsulation of docetaxel, a chemotherapeutic agent and an indoleamine 2,3 dioxygenase 1 (IDO 1) inhibitor NLG 919. The folate modification of the nanogel facilitated the tumor‐specific accumulation and pH‐responsive destruction of nanogel helped in releasing the content at the tumor site.…”

Section: Self‐assembled Multifunctional Nanomaterials For Combinatorimentioning

confidence: 99%

Engineered Multifunctional Nano‐ and Biological Materials for Cancer Immunotherapy

Brouillard

Deshpande

Kulkarni

2021

Adv Healthcare Materials

View full text Add to dashboard Cite

Cancer immunotherapy is set to emerge as the future of cancer therapy. However, recent immunotherapy trials in different cancers have yielded sub‐optimal results, with durable responses seen in only a small fraction of patients. Engineered multifunctional nanomaterials and biological materials are versatile platforms that can elicit strong immune responses and improve anti‐cancer efficacy when applied to cancer immunotherapy. While there are traditional systems such as polymer‐ and lipid‐based nanoparticles, there is a wide variety of other materials with inherent and additive properties that can allow for more potent activation of the immune system. By synthesizing and applying multifunctional strategies, it allows for a more extensive and more effective repertoire of tools to use in the wide variety of situations that cancer presents itself. Here, several types of nanoscale and biological material strategies and platforms that provide their inherent benefits for targeting and activating multiple aspects of the immune system are discussed. Overall, this review aims to provide a comprehensive understanding of recent advances in the field of multifunctional cancer immunotherapy and trends that pave the way for more diverse and tactical regression of tumors through soliciting responses by either the adaptive or innate immune system, and even both simultaneously.

show abstract

“…In parallel, DOPE lipids in the cells undergo acidification (pH < 6.5) and destabilization with lamellar-to-hexagonal transition and release of carried molecules. The results of the study suggested that this formulation could be a potential vaccine candidate for HER2/neu breast cancers [38]. DMPC-DMPG-Chol-DOPE formulation has also been used in combination with MPL to conjugate the HER2 epitope, P435 (Lip + DOPE + MPL + P435).…”

Section: Liposomementioning

confidence: 99%

Nanoparticles to Improve the Efficacy of Peptide-Based Cancer Vaccines

Tornesello

Tagliamonte

Tornesello

et al. 2020

Cancers

View full text Add to dashboard Cite

Nanoparticles represent a potent antigen presentation and delivery system to elicit an optimal immune response by effector cells targeting tumor-associated antigens expressed by cancer cells. Many types of nanoparticles have been developed, such as polymeric complexes, liposomes, micelles and protein-based structures such as virus like particles. All of them show promising results for immunotherapy approaches. In particular, the immunogenicity of peptide-based cancer vaccines can be significantly potentiated by nanoparticles. Indeed, nanoparticles are able to enhance the targeting of antigen-presenting cells (APCs) and trigger cytokine production for optimal T cell response. The present review summarizes the categories of nanoparticles and peptide cancer vaccines which are currently under pre-clinical evaluation.

show abstract

Cationic synthetic long peptides-loaded nanogels: An efficient therapeutic vaccine formulation for induction of T-cell responses

Cited by 37 publications

References 70 publications

Polymeric nanoparticle vaccines to combat emerging and pandemic threats

Polymeric nanoparticle vaccines to combat emerging and pandemic threats

Engineered Multifunctional Nano‐ and Biological Materials for Cancer Immunotherapy

Nanoparticles to Improve the Efficacy of Peptide-Based Cancer Vaccines

Contact Info

Product

Resources

About