2013
DOI: 10.1021/ja3119256
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Cations Bind Only Weakly to Amides in Aqueous Solutions

Abstract: We investigated salt interactions with butyramide as a simple mimic of cation interactions with protein backbones. The experiments were performed in aqueous metal chloride solutions using two spectroscopic techniques. In the first, which provided information about contact pair formation, the response of the amide I band to the nature and concentration of salt was monitored in bulk aqueous solutions via attenuated total reflection Fourier transform infrared spectroscopy. It was found that molar concentrations o… Show more

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Cited by 168 publications
(272 citation statements)
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“…This is consistent with the notion that the cations do not strongly interact with the carbonyl moiety of the amide. 22 The overall results of this study demonstrate that an NH moiety is not required for the salting in of polymers or peptides by ions in aqueous salt solutions.…”
Section: ■ Introductionmentioning
confidence: 68%
See 1 more Smart Citation
“…This is consistent with the notion that the cations do not strongly interact with the carbonyl moiety of the amide. 22 The overall results of this study demonstrate that an NH moiety is not required for the salting in of polymers or peptides by ions in aqueous salt solutions.…”
Section: ■ Introductionmentioning
confidence: 68%
“…Infrared spectra were measured with a Nicolet 470 FTIR spectrometer using an attenuated total reflection (ATR) attachment (Pike Miracle, Madison, WI). 22 The ATR crystal (diamond-coated ZnSe, Pike Technologies, Madison, WI) was employed in a single bounce geometry to make the measurements. The infrared radiation was detected with a liquid nitrogen-cooled MCT detector (Thermo Electron Corp., Madison, WI).…”
Section: ■ Materials and Methodsmentioning
confidence: 99%
“…This information would be key to understanding the interplay between receptor lipophilicity and anion binding in through-membrane transporters and channels. 95 Cations Cations display weaker Hofmeister phenomena, 96 and this may hinder a thorough understanding of their solvation and properties. In supramolecular chemistry, cation recognition has a long history dating back to Pedersen's crown ethers; a family of hosts that were themselves based on the earlier macrocyclic Schiff bases designed for binding transition metal cations.…”
Section: [Insert Figure 3]mentioning
confidence: 99%
“…This promotes the possibility of cation-π interactions (long-range interactions) with the metal ion. The importance of cation-π interactions in binding of metal ions with aromatic amino acids is analyzed in the literature [54,55]. In case of AMP and PEA, these long-range interactions are not very common.…”
Section: Interactions Between Metal Ions (M) and Various Pa Surfacesmentioning
confidence: 99%