Cats: A Gold Mine for Ophthalmology

Narfström, Kristina; Deckman, Koren Holland; Menotti‐Raymond, Marilyn

doi:10.1146/annurev-animal-031412-103629

Cited by 18 publications

(20 citation statements)

References 109 publications

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“…Glaucoma commonly caused by anterior segment dysgenesis and high IOP is a frequent condition seen in cats and dogs (McLellan and Miller, 2011; Pizzirani, 2015). Colonies of cats and dogs with hereditary glaucoma are available (Grozdanic et al, 2010; Kuchtey et al, 2011; Narfstrom et al, 2013). The ONH of the guinea pig has laminar beams that are radially oriented, emanating from a central fibrovascular stalk (Morrison et al, 1995; Ostrin and Wildsoet, 2016).…”

Section: Animal Models Of Glaucomamentioning

confidence: 99%

Biomechanical aspects of axonal damage in glaucoma: A brief review

Tamm

Ethier

Dowling

et al. 2017

Experimental Eye Research

100

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The biomechanical environment within the optic nerve head (ONH) is complex and is likely directly involved in the loss of retinal ganglion cells (RGCs) in glaucoma. Unfortunately, our understanding of this process is poor. Here we describe factors that influence ONH biomechanics, including ONH connective tissue microarchitecture and anatomy; intraocular pressure (IOP); and cerebrospinal fluid pressure (CSFp). We note that connective tissue factors can vary significantly from one individual to the next, as well as regionally within an eye, and that the understanding of ONH biomechanics is hindered by anatomical differences between small-animal models of glaucoma (rats and mice) and humans. Other challenges of using animal models of glaucoma to study the role of biomechanics include the complexity of assessing the degree of glaucomatous progression; and inadequate tools for monitoring and consistently elevating IOP in animal models. We conclude with a consideration of important open research questions/challenges in this area, including: (i) Creating a systems biology description of the ONH; (ii) addressing the role of astrocyte connective tissue remodeling and reactivity in glaucoma; (iii) providing a better characterization of ONH astrocytes and non-astrocytic constituent cells; (iv) better understanding the role of ONH astrocyte phagocytosis, proliferation and death; (v) collecting gene expression and phenotype data on a larger, more coordinated scale; and (vi) developing an implantable IOP sensor.

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Section: Animal Models Of Glaucomamentioning

confidence: 99%

Biomechanical aspects of axonal damage in glaucoma: A brief review

Tamm

Ethier

Dowling

et al. 2017

Experimental Eye Research

100

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“…For reverse transcription, 500 ng of RNA in 11 ml of RNase-free water was incubated in an Eppendorf Mastercycler gradient (Eppendorf AG, Hamburg, Germany, http://www. eppendorf.com) with 0.5 mg of oligo(dT) [12][13][14][15][16][17][18] primers (Life Technologies) and 0.5 mM dNTPs (Life Technologies) in a total volume of 20 ml at 65°C for 5 minutes. Following addition of 5 mM DTT, 40 U of RNasin Plus (Promega, Madison, WI, http://www.promega.com) and 200 U of Superscript III (Invitrogen) in first strand buffer, cDNA was generated by incubation at 50°C for 60 minutes, and the reaction was stopped by heating to 70°C for 15 minutes.…”

Section: Rna Isolation and Reverse Transcription-pcr Analysismentioning

confidence: 99%

“…Because the feline eye exhibits many of the anatomical and physiological characteristics of the human eye, it constitutes an appropriate model in which to undertake translational studies aimed at developing human therapies to restore visual function [12]. On this basis, we investigated methods for the delivery of RGCs into the cat eye.…”

Section: Introductionmentioning

confidence: 99%

Allogeneic Transplantation of Müller-Derived Retinal Ganglion Cells Improves Retinal Function in a Feline Model of Ganglion Cell Depletion

Becker

Eastlake

Jayaram

et al. 2015

Stem Cells Translational Medicine

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This study investigated the effect of allogeneic transplantation of feline Müller glia with the ability to differentiate into cells expressing retinal ganglion cell (RGC) markers, following ablation of RGCs by N-methyl-d-aspartate. The results suggest that Müller glia with stem cell characteristics have a neuroprotective ability that promotes partial recovery of impaired RGC function and indicate that cell attachment onto the retina may be necessary for transplanted cells to confer neuroprotection to the retina.

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“…In the feline species, ocular disorders with a well‐established inheritance pattern include ocular lesions secondary to lysosomal storage disorders, primary congenital glaucoma, retinal dystrophies, and progressive retinal atrophy . Despite the recent and rapid expansion of the Bengal breed and the frequency of ocular abnormalities reported in some of the founder breeds (Burmese, Abyssinians, Siamese), to date, the only report of a hereditary ocular abnormality in the Bengal cat breed is a recent description of an early onset autosomal recessive retinal degeneration …”

Section: Introductionmentioning

confidence: 99%

Cataracts in a population of Bengal cats in France

Bourguet

Chaudieu²,

Briatta

et al. 2017

Veterinary Ophthalmology

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Objective To document the clinical appearance and prevalence of cataracts in a French population of Bengal cats. Methods Two distinct populations of Bengal cats were examined as follows: (i) 51 animals recruited for evaluation of national prevalence of ocular diseases in an observational study conducted between October 2014 and November 2016 at the Alfort ophthalmology unit; (ii) 12 patients referred for cataract diagnosis examined at a veterinary eye clinic located in central France, between December 2014 and February 2016. Buccal swabs or blood samples for DNA analysis were collected from all patients. The pedigrees of the examined Bengal cats were also investigated. Results Cataracts were diagnosed in 23 of 51 (45%) cats in the observational study and in all cats in the referral population, mostly bilaterally. Visual impairment was never reported. Age of subjects affected by cataracts ranged from 3 months to 9.6 years (median: 1.9 years). Cataracts were classified as nuclear cataracts (14 of 23 in the observational group and 12 of 12 in the referral group) with a focal, perinuclear, posterior, or complete nuclear pattern, or posterior polar subcapsular cataracts (10 of 23 only in the observational group). An inherited congenital origin appears to be the most likely hypothesis. The pedigree analysis suggests a hereditary component of cataract formation, but further analyses in a larger population or test matings are needed to determine the exact mode of inheritance. Conclusion Presumed inherited cataracts appear to have a high prevalence in Bengal cats in France. The main manifestations are nuclear or subcapsular form, mostly bilateral, symmetrical, and apparently nonprogressive.

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Cats: A Gold Mine for Ophthalmology

Cited by 18 publications

References 109 publications

Biomechanical aspects of axonal damage in glaucoma: A brief review

Biomechanical aspects of axonal damage in glaucoma: A brief review

Allogeneic Transplantation of Müller-Derived Retinal Ganglion Cells Improves Retinal Function in a Feline Model of Ganglion Cell Depletion

Cataracts in a population of Bengal cats in France

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