Cattle and goats’ humoral response to vaccination with Clostridium perfringens type D purified epsilon toxoids

Oliveira, Ricardo de Castro; Júnior, Carlos Augusto de Oliveira; Alves, Guilherme Guerra; Assis, Ronnie Antunes de; Silva, Rodrigo; Xavier, Mauro Aparecido de Sousa; Lobato, Francisco Carlos Faria

doi:10.1016/j.anaerobe.2021.102465

Cited by 3 publications

(1 citation statement)

References 33 publications

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“…In Oliveira's 2021 study, the maximum antibody titer for both cattle and sheep hosts when given a semi-purified toxoid vaccine, purified toxoid plus mineral adjuvant, or chitosan was reported to be on the 60th day with a decrease afterward. Despite the initial decrease in antibody titer, cattle and goat hosts were still protected for 240 and 90 days after their respective vaccinations; after this point, a significant decrease was observed in some vaccine groups ( de Castro Oliveira et al., 2021 ). Blackwell and her colleagues reported that, six months after the vaccination of the goats in their study, the antitoxin titer was reduced to less than 0.10 IU/mL in 72% of the cases ( Blackwell, Butler & Bell, 1983 ).…”

Section: Discussionmentioning

confidence: 99%

Evaluation of humoral immune responses against C. perfringens epsilon toxin in Iranian sheep and goats after vaccination

Asadi

Khiav

Emadi

et al. 2023

Veterinary and Animal Science

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Section: Discussionmentioning

confidence: 99%

Evaluation of humoral immune responses against C. perfringens epsilon toxin in Iranian sheep and goats after vaccination

Asadi

Khiav

Emadi

et al. 2023

Veterinary and Animal Science

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Protection efficacy and immunogenicity of Clostridium chauvoei proteins as a subunit blackleg vaccine or an adjuvant for Clostridium perfringens epsilon toxoid

Hamzavipour,

Zahmatkesh,

Paradise

et al. 2024

Toxicon

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Evaluation of alternative vaccination routes against paratuberculosis in goats

Criado,

Silva,

Arteche-Villasol

et al. 2024

Front. Vet. Sci.

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Paratuberculosis is a chronic granulomatous enteritis, caused by Mycobacterium avium subspecies paratuberculosis (Map), that affects ruminants worldwide. Vaccination has been considered the most cost-effective method for the control of this disease in infected dairy herds. However, currently available vaccines do not provide complete protection and interfere with the diagnosis of both paratuberculosis and bovine tuberculosis, limiting its use. Because of that, efforts are being made for the development of new vaccines. The primary objective of this study was to evaluate the efficacy of two whole-cell inactivated experimental vaccines against paratuberculosis in goats, administered through the oral (OV) and intradermal (IDV) routes, and compare them with that of the commercial subcutaneous vaccine Gudair® (SCV). Over an 11-month period, the effect of vaccination and a subsequent Map challenge on the specific peripheral immune responses and Map-DNA fecal shedding were recorded. At the end of the experiment, tissue bacterial load and lesion severity were assessed. The experimental vaccines did not induce specific humoral immune responses and only elicited mild and delayed cellular immune responses. Although the OV reduced lesion severity, neither this vaccine nor the IDV prototype was able to reduce fecal shedding or tissue bacterial load. Moreover, although the SCV did not confer sterile immunity, it outperformed both experimental vaccines in all these parameters.

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Cattle and goats’ humoral response to vaccination with Clostridium perfringens type D purified epsilon toxoids

Cited by 3 publications

References 33 publications

Evaluation of humoral immune responses against C. perfringens epsilon toxin in Iranian sheep and goats after vaccination

Evaluation of humoral immune responses against C. perfringens epsilon toxin in Iranian sheep and goats after vaccination

Protection efficacy and immunogenicity of Clostridium chauvoei proteins as a subunit blackleg vaccine or an adjuvant for Clostridium perfringens epsilon toxoid

Evaluation of alternative vaccination routes against paratuberculosis in goats

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