Cattle ticks and tick-borne diseases: a review of Uganda's situation

Kasaija, Paul D.; Estrada-Peña, Agustı́n; Contreras, Marinela; Kirunda, Halid; Fuente, José de la

doi:10.1016/j.ttbdis.2021.101756

Cited by 56 publications

(46 citation statements)

References 82 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Farm management systems use conventional options such as acaricides to control tick infestation, however this is not a sustainable strategy in the long term (Mapholi et al, 2014). Intensive usage of acaricides causes pressure on pasture systems and leads to selection for acaricide-resistant tick populations (Kasaija et al, 2021). Lack of understanding on the whole genome of parasites and antigenic variation challenge sustainable use of parasite vaccines against ticks (Barréet al, 2011;Lew-Tabor and Rodriguez Valle, 2016).…”

Section: Introductionmentioning

confidence: 99%

“…Lack of understanding on the whole genome of parasites and antigenic variation challenge sustainable use of parasite vaccines against ticks (Barréet al, 2011;Lew-Tabor and Rodriguez Valle, 2016). Farmers utilize different grazing management techniques such as pasture rotation and pasture burning to reduce exposure and control tick populations (Kasaija et al, 2021). Unfortunately, climactic conditions desirable for cattle herds are also ideal for tick propagation, and grazing herds are more susceptible to heavy tick burden (Young et al, 1988;Kasaija et al, 2021).…”

Section: Introductionmentioning

confidence: 99%

“…Farmers utilize different grazing management techniques such as pasture rotation and pasture burning to reduce exposure and control tick populations (Kasaija et al, 2021). Unfortunately, climactic conditions desirable for cattle herds are also ideal for tick propagation, and grazing herds are more susceptible to heavy tick burden (Young et al, 1988;Kasaija et al, 2021). Cattle-ticks represent a top priority endemic disease for the red meat industry in Australia (Lane et al, 2015).…”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Differentially Expressed Extracellular Vesicle, Exosome and Non-Exosome miRNA Profile in High and Low Tick-Resistant Beef Cattle

Abeysinghe

Turner

Peiris

et al. 2021

Front. Cell. Infect. Microbiol.

View full text Add to dashboard Cite

Heavy tick burden on beef cattle account for huge economic losses globally, with an estimated value of US$22-30 billion per annum. In Australia, ticks cost the northern beef industry approximately A$170-200 million. Methods to evaluate and predict tick resistance would therefore be of great value to the global cattle trade. Exosomes (EX) are small extracellular vesicles (EVs) of ~30-150nm diameter and have gained popularity for their diagnostic and prognostic potential. EX contain, among other biomolecules, various types of RNA including micro-RNA (miRNA) and long noncoding RNA (lncRNA). MiRNA specifically have been validated as therapeutic biomarkers as they perform regulatory functions at the post-transcriptional level and are differentially expressed between divergent groups. The objective of the present study was to evaluate the miRNA profiles of EV and fractionated exosomal samples of high and low tick-resistant beef cattle to highlight potential miRNA biomarkers of tick resistance. Cows (n = 3/group) were classified into high or low tick resistant groups according to a novel scoring system. EVs and EX were isolated and fractionated from the blood plasma of high and low tick resistant cattle using established isolation and enrichment protocols. The resultant EX and non-EX samples were processed for next generation miRNA sequencing. Offspring of the cows in each high and low tick resistant group underwent the same processing for blood plasma EX, non-EX and miRNA analysis to evaluate the heritability of miRNA associated with tick resistance. A total of 2631 miRNAs were identified in EX and non-EX fractionated samples from high and low tick-resistant beef cattle. MiR-449a was highly expressed in maternal high tick-resistant EX samples. Of these, 174 were novel miRNAs, and 10 were differentially expressed (DE) (FDR < 0.05). These 10 DE miRNAs were also present in EVs, and three miRNAs were highly expressed: miR-2419-3p, miR-7861-3p and miR-2372-5p. Although 196 novel miRNAs were identified in fractionated samples of offspring, no miRNA were differentially expressed in these animals.

show abstract

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Differentially Expressed Extracellular Vesicle, Exosome and Non-Exosome miRNA Profile in High and Low Tick-Resistant Beef Cattle

Abeysinghe

Turner

Peiris

et al. 2021

Front. Cell. Infect. Microbiol.

View full text Add to dashboard Cite

show abstract

“…The high prevalence of ticks and tick-borne diseases (TTBDs) is a crucial hindrance to the development of the dairy industry in Uganda (Okello-Onen et al, 2003;Kasaija et al, 2021). The critical tick-borne diseases (TBDs) in Uganda are East Coast fever (ECF), babesiosis, anaplasmosis and heartwater (Byaruhanga et al, 2021;Kaiser et al, 1982;Vudriko et al, 2018).…”

Section: Introductionmentioning

confidence: 99%

“…The critical tick-borne diseases (TBDs) in Uganda are East Coast fever (ECF), babesiosis, anaplasmosis and heartwater (Byaruhanga et al, 2021;Kaiser et al, 1982;Vudriko et al, 2018). Rhipicephalus appendiculatus transmits the causative pathogen for ECF, Rhipicephalus (Boophilus) decoloratus spreads agents for babesiosis and anaplasmosis, while the pathogen for heartwater is transmitted by Amblyomma variegatum (Byaruhanga et al, 2021;Kasaija et al, 2021). Recent field observation in the country show an average tick burden of 21 R. appendiculatus, 7 R. (Boophilus) decoloratus and 3 A. variegatum ticks on grazed cattle (unpublished findings).…”

Section: Introductionmentioning

confidence: 99%

Effectiveness and limitations of the recently adopted acaricide application methods in tick control on dairy farms in South-Western Uganda

Mbatidd¹,

Bugenyi²,

Natuhwera³

et al. 2021

J. Agric. Ext. Rural Dev

View full text Add to dashboard Cite

In Uganda, control of ticks and tick-borne diseases (TTBDs) largely depends on the use of chemicals applied using different methods. This cross-sectional study assessed 17 factors to determine the effectiveness and limitations in the use of the recently adopted acaricide application methods on dairy cattle farms in south-western Uganda. The average annual morbidity and mortality due to tick-borne diseases were 42.6 and 30.0% for farms using bucket pumps, 9.3 and 4.2% for those using motorised pumps and 3.0 and 1.0% for spray races, respectively. For a 20-year period, the estimated cost of acaricide application for a herd of 80 head of cattle was US$ 71,042, US$ 38,694 and US$ 28,710 when using a bucket pump, spray race and a motorised pump, respectively. Bucket pump method may only be cost-effective on farms of 40 to 112 head of cattle, while a motorised pump was only economical for farms of 35 to 170 cattle and a spray race being a better option at farms of 100 to 600 cattle. Farmers should make the most appropriate choice of acaricide application method to achieve the most effective control of TTBDs on their farms.

show abstract

New geographical records for tick‐borne pathogens in ticks collected from cattle in Benin and Togo

Yessinou

Cazan

Panait

et al. 2022

Veterinary Medicine & Sci

View full text Add to dashboard Cite

Background Ticks are obligate hematophagous arthropods capable of transmitting a great variety of endemic and emerging pathogens causing diseases in animals and humans. Objectives The aim of this study was to investigate the presence of Bartonella spp., Rickettsia spp. , Borrelia burgdorferi sensu lato (s.l.) and Anaplasma phagocytophilum in ticks collected from cattle in Benin and Togo. Methods Overall, 396 (148 males, 205 females and 43 nymphs) ticks were collected from cattle in 17 districts (Benin and Togo) between 2019 and 2020. Ticks were pooled into groups of 2–6 ticks per pool according to individual host, location, species and developmental stage. The DNA of each pool was extracted for molecular screening. Results PCR results revealed that 20 tick pools were positive for Bartonella spp. (Benin and Togo) and 23 tick pools positive for Rickettsia spp. (Benin), while all pools were negative for A. phagocytophilum and B. burgdorferi s.l. Sequence analysis of positive Rickettsia samples revealed the presence of Rickettsia aeschlimannii . Conclusions The present study highlights the presence of zoonotic agents in ticks collected from cattle in Benin and Togo. This information will raise awareness of tick‐borne diseases among physicians and veterinarians, stimulate further studies to monitor these pathogens, and advise on necessary measures to control the spread of these zoonoses.

show abstract

Cattle ticks and tick-borne diseases: a review of Uganda's situation

Cited by 56 publications

References 82 publications

Differentially Expressed Extracellular Vesicle, Exosome and Non-Exosome miRNA Profile in High and Low Tick-Resistant Beef Cattle

Differentially Expressed Extracellular Vesicle, Exosome and Non-Exosome miRNA Profile in High and Low Tick-Resistant Beef Cattle

Effectiveness and limitations of the recently adopted acaricide application methods in tick control on dairy farms in South-Western Uganda

New geographical records for tick‐borne pathogens in ticks collected from cattle in Benin and Togo

Contact Info

Product

Resources

About