Caucasian endemic medicinal and nutraceutical plants: in-vitro antioxidant and cytotoxic activities and bioactive compounds

Manukyan, Artur; Lumlerdkij, Natchagorn; Heinrich, Michael

doi:10.1111/jphp.13093

Cited by 13 publications

(10 citation statements)

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“…-a-Lrhamnopyranoside and chlorogenic acid)-present in the leaf extract-significantly reduced lipid peroxidation and protein nitration as well as enhanced/ normalized the non-enzymatic antioxidant capacity of blood plasma in the FRAP test (Rutkowska et al 2019b). Finally, S. hajastana reduced lipid peroxidation in human plasma (Manukyan et al 2019).…”

Section: Antioxidant Activity In Cellular Modelsmentioning

confidence: 94%

“…quercetin and a-tocopherol (Hasbal et al 2015). Scientific literature reports on antioxidant potential of other Sorbus berries, like those of S. hajastana or S. sambusifgolia (Lapinskii and Gorbachev 2006;Manukyan et al 2019). DPPH and hydrogen peroxide scavenging activity as well as metal-chelating activity were also measured for methanol-water extract from S. umbellata (Desf.)…”

Section: Antiradical Activity In Chemical Modelsmentioning

confidence: 99%

“…The extract induced apoptotic process and this effect was independent of cellular p53 status (Lee et al 2017). Finally, percent of HepG2 cells viability was 78.13% after incubation with S. hajastana extract at the concentration of 200 lg/ mL (Alamar Blue assay) (Manukyan et al 2019).…”

Section: Cytotoxic Activitymentioning

confidence: 99%

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Ethnopharmacologically important but underestimated genus Sorbus: a comprehensive review

2020

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Sorbus L. sensu lato (Rosaceae family) comprises over 250 trees and shrubs growing in the Northern Hemisphere. Several Sorbus species have found their way into traditonal materia medica, as different leaf, bark or fruit preparations have a longstanding folk use. Ethnomedicine recommends their use not only in respiratory and gastrointestinal system disorders, but also in rheumatism, cancer or diabetes. Chemical composition of the genus Sorbus has been studied since 1960s and until now more than 250 compounds have been identified from thirty-eight species. The most thoroughly investigated substances are phenolic compounds (flavonoids and phenolic acids). Other constituents include triterpenes, sterols, carboxylic acids, coumarins and cyanogenic glycosides. Biological activity studies performed on the representatives of the genus Sorbus have been predominantly conducted on extracts prepared with the use of different solvents, and more rarely on isolated constituents. The majority of these studies were devoted to determination of antioxidant potential of Sorbus extracts. In a few cases targeted studies were conducted to confirm specific folk usage. Two of the fairly well documented medicinal uses are the antidiabetic activity of Sorbus decora and antiinflammatory activity of Sorbus commixta. Keywords Sorbus Á Folk medicine Á Phytochemistry Á Biological activity Abbreviations AAPH 2,2 0 -Azobis-(2-amidinopropane) dihydrochloride ABTS 2,2 0 -Azino-bis(3-ethylbenzothioazoline-6sulphonic acid) diammonium salt ACE Angiotensin converting enzyme AChE Acetylcholinesterase ADH Alcohol dehydrogenase ALT Alanine aminotransferase AMPK Adenosine-monophosphate-activated protein kinase AST Aspartate transaminase ATO Arsenic trioxide BChE Butyrylcholinesterase CAT Catalase CD Conjugated dienes cGMP Guanosine 3 0 ,5 0 -cyclic monophosphate COX-2 Cyclooxygenase-2 CYP Cytochrome P450 DMPD ? N,N-Dimethyl-p-phenylenediamine DPPH 2,2 0 -Diphenyl-1-picrylhydrazyl dw Dry weight ecNOS Endothelial cell NO synthase EDTA Ethylenediamine tetraacetic acid

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Section: Antioxidant Activity In Cellular Modelsmentioning

confidence: 94%

Section: Antiradical Activity In Chemical Modelsmentioning

confidence: 99%

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Ethnopharmacologically important but underestimated genus Sorbus: a comprehensive review

2020

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“…HepG2 hücre hattı kullanılarak başka Centaurea türlerinden hareketle hazırlanmış olan ekstrelerin sitotoksik aktivitelerine ait çalışmalar incelendiğinde, birçok türün de sitotoksik aktivitesinin bulunduğu görülmüştür (20)(21)(22). Aynı hücre hattında P. pyrrhoblepharus toprak üstü kısımlarından hazırlanmış olan ekstrelerimizin sitotoksik aktiviteleri karşılaştırıldığında, en yüksek aktiviteyi kloroform ekstresinin gösterdiği tespit edilmiştir.…”

Section: Discussionunclassified

Potential Cytotoxic Activity of Psephellus pyrrhoblepharus Extracts

Taştan¹,

Armağan

Dağcı

et al. 2021

Kahramanmaraş Sütçü İmam Üniversitesi Tıp Fakültesi Dergisi

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Objective: In Psephellus and Centaurea genuses,various species have important pharmacological activities like antipyretic, antiinflamatory, diuretic, cytotoxic etc. The interest in use of plant-derived compounds for therapeutic purposes in cancer is increasing day by day. Liver cancer affects millions of people all over the world. So, any therapeutic approach to treat liver cancer is extremely valuable. In this study, it was aimed to evaluate the cytotoxic potential of methanol: water (1: 1), chloroform and n-hexane extracts prepared from the aerial parts of P. pyrrhoblepharus plant using human liver cancer cells (HepG2). Materials and Methods:The endemic plant Psephellus pyrrhoblepharus (Boiss.) Wagenitz (Centaurea pyrrhoblephara) wascollected from Elazığ, Turkey and extracts were prepared. Human liver cancer cell (HepG2)were treated by different concentrations (50, 100, 200 µg/mL) of extracts at different time points (6, 12 and 24 h) and the changes in cell viability were measured by using the 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazoliumbromide (MTT) assay.Results: Regarding the cytotoxicity, cell viability was observed to decrease following extract exposures at three different time points. The highest cytotoxic activity was foundat 100 µg/mL concentrations of chloroform extract at 24 h(p˂0.05). At 12 h, chloroform extract of plant showed the highest cytotoxic activity at 200 µg/mL concentrations when compared to methanol:water and n-hexane extracts. Conclusion:It can be suggested that extracts of P. pyrrhoblepharus show dose-dependent and time-dependent cytotoxic effects in HepG2 carsinoma cells. In general, the results provide information about the threshold concentrations of P. pyrrhoblepharus extracts that might be used in different applications without the risk of toxicity.

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“…The antiproliferative property of hawthorn against liver cancer cells has been largely determined using a cell-based MTT assay in HepG2 and Hep3B cells. Among the various species of hawthorn, C. pinnatifida, C. monogyna, and C. armena have significantly suppressed the cell viability of human hepatoma cells, including HepG2 and Hep3B cells [20,[86][87][88][89][90], while the water extract of C. aronia effectively increased the level of reduced intracellular antioxidant glutathione and glutathione disulfide in HepG2 cells, indicating no significant cytotoxicity against tumors. Interestingly, the 80% ethanol extract of C. monogyna exhibited dose-dependent cytotoxic activity toward HepG2 cells, although the extract had abundant polyphenolic compounds and zinc, possessing antioxidant properties [87].…”

Section: Anticancer Effectsmentioning

confidence: 99%

Potential Roles and Key Mechanisms of Hawthorn Extract against Various Liver Diseases

2022

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The genus Crataegus (hawthorn), a flowering shrub or tree, is a member of the Rosaceae family and consists of approximately 280 species that have been primarily cultivated in East Asia, North America, and Europe. Consumption of hawthorn preparations has been chiefly associated with pharmacological benefits for cardiovascular diseases, including congestive heart failure and angina pectoris. Treatment with hawthorn extracts can be related to improvements in the complex pathogenesis of various hepatic and cardiovascular disorders. In this regard, the present review described that the presence of hawthorn extracts ameliorated hepatic injury, lipid accumulation, inflammation, fibrosis, and cancer in an abundance of experimental models. Hawthorn extracts might have these promising activities, largely by enhancing the hepatic antioxidant system. In addition, several mechanisms, including AMP-activated protein kinase (AMPK) signaling and apoptosis, are responsible for the role of hawthorn extracts in repairing the dysfunction of injured hepatocytes. Specifically, hawthorn possesses a wide range of biological actions relevant to the treatment of toxic hepatitis, alcoholic liver disease, non-alcoholic fatty liver disease, and hepatocellular carcinoma. Accordingly, hawthorn extracts can be developed as a major source of therapeutic agents for liver diseases.

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Caucasian endemic medicinal and nutraceutical plants: in-vitro antioxidant and cytotoxic activities and bioactive compounds

Cited by 13 publications

References 50 publications

Ethnopharmacologically important but underestimated genus Sorbus: a comprehensive review

Ethnopharmacologically important but underestimated genus Sorbus: a comprehensive review

Potential Cytotoxic Activity of Psephellus pyrrhoblepharus Extracts

Potential Roles and Key Mechanisms of Hawthorn Extract against Various Liver Diseases

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