Cauda equina arachnoiditis – a rare manifestation of West Nile virus neuroinvasive disease: A case report

Abstract

BACKGROUND Data regarding the neuroradiology features of the West Nile virus neuroinvasive disease (WNV NID) is rather scarce. To contribute to the knowledge of the WNV NID, we present a patient with a combination of encephalitis and acute flaccid paresis, with cauda equina arachnoiditis as the main magnetic resonance (MR) finding. CASE SUMMARY A 72-year-old female patient was admitted due to fever, headache and gait instability. During the first several days she developed somnolence, aphasia, urinary incontinence, constipation, and asymmetric lower extremities weakness. Cerebrospinal fluid analysis indicated encephalitis. Native brain computed tomography and MR were unremarkable, while spinal MR demonstrated cauda equina enhancement without cord lesions. Virology testing revealed WNV IgM and IgG antibodies in serum and cerebrospinal fluid, which confirmed acute WNV NID. The treatment was supportive. After two months only a slight improvement was noticed but cognitive impairment, loss of sphincter control and asymmetric inferior extremities weakness remained. The patient died after a month on chronic rehabilitation. CONCLUSION Cauda equina arachnoiditis is a rare, but possible neuroradiological feature in acute flaccid paresis form of WNV NID.

Antiviral Cytokine Response in Neuroinvasive and Non-Neuroinvasive West Nile Virus Infection

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“…A total of 474 patients with the neuroinvasive disease were included in the study. Arboviral etiology was confirmed in 114 (24.1%) patients: WNV in 62 (13.1%), TBEV in 46 (9.7%), USUV in 3 (0.6%), and TOSV in 3 (0.6%) patients [ 3 , 4 , 13 , 44 , 74 , 75 , 76 , 77 ]. Seasonal and geographic distribution of arbovirus infections are presented in Figure 1 .…”

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