Caudate volume differences among treatment responders, non-responders and controls in children with obsessive–compulsive disorder

Vattimo, Edoardo Filippo de Queiroz; Barros, Vivian Boschesi; Requena, Guaraci; Sato, João Ricardo; Fatori, Daniel; Miguel, Eurí­pedes Constantino; Shavitt, Roseli Gedanke; Hoexter, Marcelo Q.; Batistuzzo, Marcelo C.

doi:10.1007/s00787-019-01320-w

Cited by 6 publications

(3 citation statements)

References 70 publications

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“…In addition, our OCD sample was primarily treatment na€ ıve whereas the ENIGMA sample included previously medicated participants. Prior data suggest that caudate volume in children/adolescents predicts treatment outcomes, but this was not specific to CBT (n = 17 in group CBT and n = 12 receiving fluoxetine) (Vattimo et al, 2019). Herein, thinner cortex in frontoparietal regions robustly predicted greater CY-BOCS improvement after individual CBT among pediatric patients with OCD.…”

Section: Discussionmentioning

confidence: 86%

“…Diffusion MRI findings examining white matter structure have been mixed, identifying either no differences (Fitzgerald et al, 2014;Jayarajan et al, 2012;Silk et al, 2013), greater (Gruner et al, 2012;Zarei et al, 2011) or lower fractional anisotropy (FA) (Lazaro et al, 2014a;Rosso et al, 2013), or lower white matter volume (Chen et al, 2013;Lazaro et al, 2014b) in pediatric OCD across mainly corpus callosum, frontal, and cingulate areas. One pediatric study suggested that caudate volume predicts response to group CBT or pharmacotherapy (Vattimo et al, 2019), but no study, to our knowledge, has assessed brain structure or structural connectivity as predictors of individual CBT in unmediated pediatric OCD.…”

Section: Introductionmentioning

confidence: 99%

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Structural neural markers of response to cognitive behavioral therapy in pediatric obsessive‐compulsive disorder

Pagliaccio

Cha

et al. 2019

Child Psychology Psychiatry

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Background Cognitive behavioral therapy (CBT) is an effective, first‐line treatment for pediatric obsessive‐compulsive disorder (OCD). While neural predictors of treatment outcomes have been identified in adults with OCD, robust predictors are lacking for pediatric patients. Herein, we sought to identify brain structural markers of CBT response in youth with OCD. Methods Twenty‐eight children/adolescents with OCD and 27 matched healthy participants (7‐ to 18‐year‐olds, M = 11.71 years, SD = 3.29) completed high‐resolution structural and diffusion MRI (all unmedicated at time of scanning). Patients with OCD then completed 12–16 sessions of CBT. Subcortical volume and cortical thickness were estimated using FreeSurfer. Structural connectivity (streamline counts) was estimated using MRtrix. Results Thinner cortex in nine frontoparietal regions significantly predicted improvement in Children’s Yale‐Brown Obsessive‐Compulsive Scale (CY‐BOCS) scores (all ts > 3.4, FDR‐corrected ps < .05). These included middle and superior frontal, angular, lingual, precentral, superior temporal, and supramarginal gyri (SMG). Vertex‐wise analyses confirmed a significant left SMG cluster, showing large effect size (Cohen’s d = 1.42) with 72.22% specificity and 90.00% sensitivity in predicting CBT response. Ten structural connections between cingulo‐opercular regions exhibited fewer streamline counts in OCD (all ts > 3.12, Cohen’s ds > 0.92) compared with healthy participants. These connections predicted post‐treatment CY‐BOCS scores, beyond pretreatment severity and demographics, though not above and beyond cortical thickness. Conclusions The current study identified group differences in structural connectivity (reduced among cingulo‐opercular regions) and cortical thickness predictors of CBT response (thinner frontoparietal cortices) in unmedicated children/adolescents with OCD. These data suggest, for the first time, that cortical and white matter features of task control circuits may be useful in identifying which pediatric patients respond best to individual CBT.

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Section: Discussionmentioning

confidence: 86%

Section: Introductionmentioning

confidence: 99%

Structural neural markers of response to cognitive behavioral therapy in pediatric obsessive‐compulsive disorder

Pagliaccio

Cha

et al. 2019

Child Psychology Psychiatry

View full text Add to dashboard Cite

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“…Such broadness stemmed from a vision that, given the large size of the University of Sã o Paulo (USP), a lab dedicated to a subspecialty of key relevance to psychiatry should not be limited to support research performed by the laboratory's leaders, but rather should serve as a platform for collaborations with other research groups. Additionally, it should be noted that other leaders at IPq-HCFMUSP have coordinated neuroimaging research initiatives independently from LIM 21 in areas of MRS applied to mood disorders and psychosis, [31][32][33][34] morphometric MRI in mood disorders, obsessive-compulsive disorder, and psychosis, [35][36][37] functional imaging studies in obsessivecompulsive disorder, [38][39][40] and psychiatric manifestations of neurological disorders. [41][42][43] A specialized psychiatric neuroimaging lab was also set up at the Federal University of Sã o Paulo (UNIFESP) in 2004, with support from FAPESP and other funding agencies.…”

Section: The Concept Of Neuroimaging As a Subspecialty In Psychiatric Research And The Establishment Of Psychiatric Neuroimaging Researchmentioning

confidence: 99%

Psychiatric neuroimaging research in Brazil: historical overview, current challenges, and future opportunities

Busatto

Rosa

Squarzoni

et al. 2021

Braz. J. Psychiatry

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The last four decades have witnessed tremendous growth in research studies applying neuroimaging methods to evaluate pathophysiological and treatment aspects of psychiatric disorders around the world. This article provides a brief history of psychiatric neuroimaging research in Brazil, including quantitative information about the growth of this field in the country over the past 20 years. Also described are the various methodologies used, the wealth of scientific questions investigated, and the strength of international collaborations established. Finally, examples of the many methodological advances that have emerged in the field of in vivo neuroimaging are provided, with discussion of the challenges faced by psychiatric research groups in Brazil, a country of limited resources, to continue incorporating such innovations to generate novel scientific data of local and global relevance.

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The Longitudinal Relationship Between Brain Morphology and Obsessive-Compulsive Symptoms in Children From the General Population

Weeland,

Vriend,

Tiemeier

et al. 2024

JAACAP Open

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Caudate volume differences among treatment responders, non-responders and controls in children with obsessive–compulsive disorder

Cited by 6 publications

References 70 publications

Structural neural markers of response to cognitive behavioral therapy in pediatric obsessive‐compulsive disorder

Structural neural markers of response to cognitive behavioral therapy in pediatric obsessive‐compulsive disorder

Psychiatric neuroimaging research in Brazil: historical overview, current challenges, and future opportunities

The Longitudinal Relationship Between Brain Morphology and Obsessive-Compulsive Symptoms in Children From the General Population

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