Establishing a purposive interaction with a patient who is in a vulnerable situation prior to coronary artery bypass graft (CABG) surgery poses a challenge for the nurse anesthetist. The aim of this study was to identify and describe the interaction between the patient and nurse anesthetist immediately prior to elective CABG surgery. An observational study including 11 situations where the patient and the nurse anesthetist interacted was performed. A theoretical selection of patients and nurse anesthetists was made and data were analyzed using constant comparative method. The core category, Reassurance, emerged from the categories Continuity, Confirmation and Control. Continuity was characterized by expedient anesthesia nursing of high quality, Confirmation was related to communication in a trusting atmosphere and Control was associated with skilled nursing interventions in the thoracic operating theatre.In conclusion, reassurance can be achieved through a well-structured anesthesia nursing performance at the thoracic operating theatre, and by focusing on the patient and continuously giving him/her information during the preoperative preparation.