Caulerpenyne, an unusual sequiterpenoid from the green alga caulerpa prolifera

Amico, Vincenzo; Oriente, Giovanna; Piattelli, Mario; Tringali, Corrado; Fattorusso, Ernesto; Magno, Silvana; Mayol, Luciano

doi:10.1016/s0040-4039(01)95003-8

Cited by 125 publications

(71 citation statements)

References 7 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…The purified CYN was analysed by reverse-phase HPLC and 1 H NMR spectroscopy in order to determine its purity. NMR data were identical with those reported in the literature [15].…”

Section: Chromatographic Isolation Of Cynsupporting

confidence: 83%

See 1 more Smart Citation

Inhibition of xanthine oxidase by Caulerpenyne from Caulerpa prolifera

Cengiz¹,

Çavaş²,

Yurdakoç³

et al. 2012

Turk J Bioch

View full text Add to dashboard Cite

“…The purified CYN was analysed by reverse-phase HPLC and 1 H NMR spectroscopy in order to determine its purity. NMR data were identical with those reported in the literature [15].…”

Section: Chromatographic Isolation Of Cynsupporting

confidence: 83%

“…The present study evaluates the potential of caulerpenyne (CYN) as a XOD inhibitor. CYN is the main secondary metabolite of Caulerpa species which was firstly isolated from Caulerpa prolifera [15]. So far, anticarcinogenic, antiviral and apoptotic properties of CYN have been reported [16][17][18][19][20].…”

Section: Introductionmentioning

confidence: 99%

Inhibition of xanthine oxidase by Caulerpenyne from Caulerpa prolifera

Cengiz¹,

Çavaş²,

Yurdakoç³

et al. 2012

Turk J Bioch

View full text Add to dashboard Cite

“…The compounds were identified by comparison of 1 H-and 13 C-NMR (proton and carbon nuclear magnetic resonance)-recorded data with the literature values (Amico et al 1978, Maiti et al 1978, Nielsen et al 1982. NMR spectra were recorded on Bruker AM 400 MHz and Bruker DPX 300 MHz spectrometers in CDCl 3 and DMSO-d6.…”

Section: Methodsmentioning

confidence: 99%

Detrimental physiological effects of the invasive alga Caulerpa racemosa on the Mediterranean white seabream Diplodus sargus

Terlizzi¹,

Felline²,

Lionetto³

et al. 2011

Aquat. Biol.

View full text Add to dashboard Cite

Observational data suggest that the white seabream Diplodus sargus, a sparid fish of economic and ecological relevance in the Mediterranean Sea, has included the invasive green alga Caulerpa racemosa in its diet. Here we adopted a chemoecological approach to study the trophic relationship between the fish and the exotic pest. We demonstrated that the red pigment caulerpin, the most abundant secondary metabolite of C. racemosa, enters food chains and accumulates in the fish tissues. General biological condition markers associated with fish health and reproductive development were measured and correlated with the caulerpin levels in the fish tissues. Significant correlations among caulerpin tissue load (determined by liquid chromatography-mass spectrometry analysis) and fish condition factor and hepatosomatic index were obtained, suggesting a possible detrimental effect of the dietary exposure to C. racemosa on D. sargus. Glutathione peroxidase and catalase activity were also significantly correlated with caulerpin concentrations in the liver, suggesting a possible interaction between algal metabolites and liver antioxidant mechanisms. Studies on the impact of invasive macroalgae on marine assemblages have been almost exclusively focused on the structural modification of benthic assemblages, through the alteration of the relative importance of some endemic species and the modification of habitat complexity. Here we propose a new mechanism by which invasive algae can impact marine systems, namely the entry of pest metabolites in food webs, with potential detrimental effects on the population dynamics of a single species, alteration of trophic webs and changes in the functioning of coastal ecosystems.

show abstract

“…Australian workers studying Caulerpa species from southern Australia found various terpenes such as caulerpol, flexilin, and trifarin Wells, 1976, 1978). Caulerpenyne, a unique acetylenic sesquiterpenoid that is closely related to flexilin, was first isolated from a Mediterranean collection of C. prolifera (Amico et al, 1978), but has since been found as the major metabolite in many other Caulerpa spp. (Fig.…”

Section: Caulerpenynementioning

confidence: 99%