Caulerpenyne from Caulerpa taxifolia has an antiproliferative activity on tumor cell line SK-N-SH and modifies the microtubule network

Barbier, Pascale; Guise, S.; Huitorel, Philippe; Amade, Philippe; Pesando, D.; Briand, Claudette; Peyrot, Vincent

doi:10.1016/s0024-3205(01)01396-0

Cited by 98 publications

(61 citation statements)

References 21 publications

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“…and caulerpenyne have been reported to show antimicrobial (Hodgson, 1984;Paul and Fenical, 1986;Smyrniotopoulos et al, 2003;Freile-Pelegrín and Morales, 2004) and antiproliferative (Hodgson, 1984;Fischel et al, 1995;Cavas et al, 2006) activities. Caulerpenyne blocked cleavage of developing sea urchin eggs (Paul and Fenical, 1986;Pesando et al, 1996), most likely because it inhibits microtubule polymerization (Barbier et al, 2001) and can induce apoptosis in mammalian (neuroblastoma) cells (Cavas et al, 2006). Allelopathic activities have also been reported for extracts of Caulerpa spp.…”

Section: Caulerpenynementioning

confidence: 99%

Chemical Defenses: From Compounds to Communities

Paul

Arthur

Ritson‐Williams

et al. 2007

The Biological Bulletin

180

152

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Section: Caulerpenynementioning

confidence: 99%

Chemical Defenses: From Compounds to Communities

Paul

Arthur

Ritson‐Williams

et al. 2007

The Biological Bulletin

180

152

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“…These secondary metabolites provide defense against herbivores (Pereira et al, 2004b;Lima et al, 2008), fouling organisms (Da Gama et al, 2008) and pathogens (Paul & Ritson-Williams, 2008); they also play a role in reproduction (Amsler & Fairhead, 2005), protection from UV radiation (Gomez et al, 1998) and as allelopathic agents (Beach et al, 2003). These compounds have shown some interesting pharmacological activities such as: antitumoral (Barbier et al, 2001), antiparasitic (Davyt et al, 2001), antibacterial (Vairappan, 2003), antiviral (Santos et al, 1999;Pereira et al, 2004a;Soares et al, 2007), antioxidant (Nahas et al, 2007), and antifungal activity (de Oliveira et al, 2008). In particular, antiviral effects of sulfated polysaccharides and terpenes against a variety of enveloped viruses, such as Herpes Simplex Virus type 1 (HSV-1) and 2 (HSV-2), Human Immunodefi ciency Virus (HIV), human cytomegalovirus, dengue viruses, respiratory syncytial and infl uenza viruses have been reported (Laillea et al, 1998;Ghosh et al, 2004;Cirne-Santos et al, 2008;Hidari et al, 2008).…”

Section: Introductionmentioning

confidence: 99%

Antiviral activity of extracts from Brazilian seaweeds against herpes simplex virus

Soares¹,

Robaina²,

Mendes³

et al. 2012

Rev. bras. farmacogn.

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Organic extracts of 36 species of marine algae (sixteen species of Rhodophyta, eight species of Ochrophyta and twelve species of Chlorophyta) from seven locations on the Brazilian coast were evaluated for their anti-HSV-1 and anti-HSV-2 activity resistant to Acyclovir (ACV). Activity tests in crude extracts, followed by the identification of the major compounds present, were performed for all species. The chemical profiles of all crude extracts were obtained by 1 H-NMR and 13 C-NMR spectroscopy. The percentage of extracts with antiviral activity was higher for HSV-1 (86.1%) than for HSV-2 (55.5%). The green algae Ulva fasciata and Codium decorticatum both showed the highest activity (99.9%) against HSV-1, with triacylglycerols and fatty acids as the major components. The red alga Laurencia dendroidea showed good activity against HSV-1 (97.5%) and the halogenated sesquiterpenes obtusol and (-)-elatol were identified as the major components in the extract. Against HSV-2, the green alga Penicillus capitatus (Chlorophyta) and Stypopodium zonale (Ochrophyta) were the most active (96.0 and 95.8%). Atomaric acid, a meroditerpene, was identified as the major secondary metabolite in the S. zonale extract. These results reinforce the role of seaweeds as important sources of compounds with the potential to enter into the pipeline for development of new drugs against herpes simplex.

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“…Caulerpales produce secondary metabolites that have been previously investigated for their ecological role both in the chemical defence against herbivores (McConnell et al 1982, Pe san do et al 1996, Lemée et al 1997) and as allelochemicals in in-terspecific competition among marine macrophytes (Raniello et al 2007). Various studies have evaluated the toxic effect of these compounds on vertebrates and invertebrates (Lemée et al 1993, Schröder et al 1998, Barbier et al 2001, Mozzachiodi et al 2001, Paul et al 2007). The homogenate of Caulerpa taxifolia affects the physiology of the black scopionfish Scorpaena porcus by altering enzymatic detoxification systems in their livers (Uchimura et al 1999).…”

Section: Introductionmentioning

confidence: 99%

Detrimental physiological effects of the invasive alga Caulerpa racemosa on the Mediterranean white seabream Diplodus sargus

Terlizzi¹,

Felline²,

Lionetto³

et al. 2011

Aquat. Biol.

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Observational data suggest that the white seabream Diplodus sargus, a sparid fish of economic and ecological relevance in the Mediterranean Sea, has included the invasive green alga Caulerpa racemosa in its diet. Here we adopted a chemoecological approach to study the trophic relationship between the fish and the exotic pest. We demonstrated that the red pigment caulerpin, the most abundant secondary metabolite of C. racemosa, enters food chains and accumulates in the fish tissues. General biological condition markers associated with fish health and reproductive development were measured and correlated with the caulerpin levels in the fish tissues. Significant correlations among caulerpin tissue load (determined by liquid chromatography-mass spectrometry analysis) and fish condition factor and hepatosomatic index were obtained, suggesting a possible detrimental effect of the dietary exposure to C. racemosa on D. sargus. Glutathione peroxidase and catalase activity were also significantly correlated with caulerpin concentrations in the liver, suggesting a possible interaction between algal metabolites and liver antioxidant mechanisms. Studies on the impact of invasive macroalgae on marine assemblages have been almost exclusively focused on the structural modification of benthic assemblages, through the alteration of the relative importance of some endemic species and the modification of habitat complexity. Here we propose a new mechanism by which invasive algae can impact marine systems, namely the entry of pest metabolites in food webs, with potential detrimental effects on the population dynamics of a single species, alteration of trophic webs and changes in the functioning of coastal ecosystems.

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Caulerpenyne from Caulerpa taxifolia has an antiproliferative activity on tumor cell line SK-N-SH and modifies the microtubule network

Cited by 98 publications

References 21 publications

Chemical Defenses: From Compounds to Communities

Chemical Defenses: From Compounds to Communities

Antiviral activity of extracts from Brazilian seaweeds against herpes simplex virus

Detrimental physiological effects of the invasive alga Caulerpa racemosa on the Mediterranean white seabream Diplodus sargus

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