Causal Association between Bone Mineral Density and Osteoarthritis: A Mendelian Randomization Study

Song, Gwan Gyu; Lee, Young Ho

doi:10.4078/jrd.2019.26.2.104

Cited by 9 publications

(3 citation statements)

References 27 publications

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“…Alternatively, the causal pathway between BMD and BMI makes sense via the metabolism bone turnover effect (Kemp et al, 2016) According to Nevitt and colleagues, high BMD can be associated with an increased risk of OA. High bone density can increase the risk of in knee and hip OA (Nevitt et al, 2010)This is a direct consequence of increased mechanical stress on the cartilage of the subchondral cortical plate (Song & Lee, 2019). This might happen because bone density does not help reduce joint load but increases the burden on joint cartilage, making it easier to tear.…”

Section: Introductionmentioning

confidence: 99%

The relationship of body mass index and T score in healthy and knee osteoarthritis women

Achmad,

Suharjono,

Soeroso

et al. 2023

Pharm Educ

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Background: Osteoarthritis (OA) is a chronic, degenerative, slowly progressive disease common in women with multiple aetiology. Osteoarthritis occurs simultaneously with the reduction in bone mineral density (BMD)while a high bone mass index (BMI) value is one of the risk factors for OA. Objective: The purpose of this study was to determine the effect of BMI and BMD in healthy and knee OA women. Method: The study was conducted in an orthopaedic outpatient clinic in 2021. This is a quantitative descriptive study with accidental cross-sectional samplings. The Mann-Whitney test was used to analyse the data. Result: Subjects included in the inclusion criteria obtained 74 OA and 49 control groups. The largest subjects in the OA group were aged 56-65 years old (32, 43.24%), obese (51, 68.92%), and post-menopause (49, 66.22%). At the same time, the T score category was normal (14, 18.91%), osteopenia (22, 29.73%), and osteoporosis (38, 51.35%). Statistical analysis found a significant relationship between BMI and BMD (p = 0.002, p = 0.001) in controls and OA groups. Conclusion: Disorders of BMI and BMD are indicators of risk for OA. High BMI and low BMD values occur in women with knee OA. There is a relationship between BMI and BMD in healthy and knee OA women.

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Section: Introductionmentioning

confidence: 99%

The relationship of body mass index and T score in healthy and knee osteoarthritis women

Achmad,

Suharjono,

Soeroso

et al. 2023

Pharm Educ

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“…Mendelian randomization (MR) is a methodology that uses genetic variants as instrumental variables (IVs) to determine whether the observational interaction between the risk factor and the disease is compatible with the causal impact [ 9 , 10 ]. The purpose of this research was to investigate whether intestinal microbiota is causally correlated with the occurrence of OA by means of a two-sample MR examination.…”

Section: Introductionmentioning

confidence: 99%

The Gut Microbiome and Osteoarthritis: A Two-Sample Mendelian Randomization Study

Lee

Song

2021

J Rheum Dis

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The aim of this study was to examine if the intestinal microbiome is causally correlated with osteoarthritis (OA) incidence. Methods. A two-sample Mendelian randomization (MR) study was conducted using inverse variance weighting (IVW), weighted median, and MR-Egger regression techniques. Publicly accessible summary statistics dataset of intestinal microbiomes of European descent from genome-wide association studies (GWASs) (a total with 3,326 individuals) was used as an exposure. As an outcome, summary data from the GWAS include 3,498 patients with OA of the knee and hip from the arcOGEN sample and 11,009 controls of European descent. Results. We identified 29 single-nucleotide polymorphisms from GWAS of intestinal microbiomes as instrumental variables. The IVW approach found no evidence to suggest a causal relationship between the intestinal microbiota and OA (beta=−0.001, standard error [SE]=0.004, p=0.748). The regression test of MR-Egger showed that the directional pleiotropy was unlikely to be a bias (intercept=0.002, SE=0.007, p=0.697) and the MR-Egger study showed no causal relation between the intestinal microbiota and the OA (beta=−0.002, SE=0.005, p=0.630). The weighted median analysis also did not have indications of a causal relationship between the intestinal microbiota and OA (beta=−0.002, SE=0.005, p=0.630). The MR results calculated using IVW, the median weighted and the MR-Egger regression approaches were consistent. Conclusion. The findings of the MR analysis did not support a causal relationship between intestinal microbiome and OA risk.

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“…MR studies use singlenucleotide polymorphisms (SNPs) as instrumental variables to avoid the reverse causation and confounding factors which cause bias in traditional observational studies [25,26]. MR method has been applied to estimate the causal associations between body mass index (BMI) [27], bone mineral density (BMD) [28], smoking [29] and coffee intake [30], and OA. In addition, robust causal associations of interleukin-6 [31], blood magnesium [32], and vitamin D [33] with RA have been demonstrated by previous MR approach-based studies.…”

Section: Introductionmentioning

confidence: 99%

Sex hormone-binding globulin and arthritis: a Mendelian randomization study

Huang

Yang

et al. 2020

Arthritis Res Ther

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Background Sex hormone-binding globulin (SHBG) has been reported to be a risk factor associated with the development of arthritis by previous observational studies more so of three common forms of arthritis: osteoarthritis (OA), rheumatoid arthritis (RA), and ankylosing spondylitis (AS). This study aimed to determine whether the concentrations of circulating SHBG are causally associated with the risk of OA, RA, and AS. Methods The two-sample Mendelian randomization (MR) approach was used for this study. The inverse-variance-weighted (IVW) method was used for the main analysis. Single-nucleotide polymorphisms (SNPs) associated with SHBG were selected from a large genome-wide association study (GWAS) of 28,837 European individuals. The summary statistics for OA, RA, and AS were extracted from the UK Biobank Resource (n = 361,141) and a GWAS dataset (n = 455,221). Results Positive causal associations were found between circulating SHBG concentrations and OA (effect = 1.086; 95% CI, 1.009 to 1.168; P = 0.027) and RA (effect = 1.003; 95% CI, 1.000 to 1.007; P = 0.047) in overall analyses. However, there was no evidence of association between SHBG levels and AS. Based on the stratification of skeletal sites, SHBG levels were found to be significantly associated with hip OA (effect = 1.423; 95% CI, 1.219 to 1.660; P = 7.753 × 10−6). However, this was not the case with knee OA. Conclusions There were positive causal effects of circulating SHBG on the development of OA and RA. Moreover, there was a site-specific association between SHBG and hip OA. Evidently, measurement of SHBG in serum could be valuable in the clinical assessment of arthritis especially in early screening and prevention of OA and RA. However, the mechanisms by which SHBG plays causal roles in the development of arthritis require further investigations.

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Causal Association between Bone Mineral Density and Osteoarthritis: A Mendelian Randomization Study

Cited by 9 publications

References 27 publications

The relationship of body mass index and T score in healthy and knee osteoarthritis women

The relationship of body mass index and T score in healthy and knee osteoarthritis women

The Gut Microbiome and Osteoarthritis: A Two-Sample Mendelian Randomization Study

Sex hormone-binding globulin and arthritis: a Mendelian randomization study

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