Causal association between vitamin D and diabetic neuropathy: a Mendelian randomization analysis

Huang, Wei; Gu, Lei; Wang, Jingwen; Wang, Yiqi; Cao, Fangzheng; Jin, Tianyu; Cheng, Yifan

doi:10.1007/s12020-023-03315-9

Cited by 3 publications

(2 citation statements)

References 61 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…These findings suggest that patients with hypovitaminosis D should be followed up for the development of diabetic neuropathic changes, even if glucose control is achieved [45]. There was evidence for an association between lower serum 25(OH)D levels and higher prevalence of DPN in individuals with obesity [46]; however, there was no evidence to support the causal association of serum 25(OH)D levels with diabetic neuropathy [47]. Studies also indicated important roles of vitamin D in postherpetic neuralgia (PHN) [48], multiple myeloma [49], CIPN [50], carpal tunnel syndrome (CTS) [50], and plexiform neurofibromas (PNFs) [51].…”

Section: Vitamin Dmentioning

confidence: 89%

“…Vitamin D, a fat-soluble compound best known for its effect on bone metabolism, plays an important role in calcium homeostasis. Vitamin D is a steroid, functioning as a hormone in the human body and having a role in glucose homeostasis and sensitivity to insulin There was evidence for an association between lower serum 25(OH)D levels and higher prevalence of DPN in individuals with obesity [46]; however, there was no evidence to support the causal association of serum 25(OH)D levels with diabetic neuropathy [47]. Studies also indicated important roles of vitamin D in postherpetic neuralgia (PHN) [48], multiple myeloma [49], CIPN [50], carpal tunnel syndrome (CTS) [50], and plexiform neurofibromas (PNFs) [51].…”

Section: Vitamin Dmentioning

confidence: 99%

See 1 more Smart Citation

Vitamins in neuropathy: pathophysiological and therapeutic roles

Chen,

Song

2023

Current Opinion in Neurology

View full text Add to dashboard Cite

Purpose of review Vitamin deficiency is a risk factor in the development of peripheral neuropathy, which leads to complex and severe diseases. This review provides an update overview of the literature on the roles of vitamins in peripheral neuropathy, highlighting their pathophysiological and therapeutic roles. Recent findings The importance and clinical manifestations and implications of the vitamins and vitamin deficiencies are further demonstrated in peripheral neuropathy and the associated diseases. Vitamin deficiency is common in various severe and complex diseases such as diabetes, chemotherapy, acute nutritional axonal neuropathy, dermatitis, complex regional pain syndrome, postherpetic neuralgia, carpal tunnel syndrome, and so forth and some rare clinical case reports. There is evidence that deficiencies of almost all vitamins are associated with diabetic neuropathy. Vitamin supplementation may serve as an effective therapeutic strategy. Summary The vitamins play critical roles in maintaining physiological functions, and vitamin deficiencies cause peripheral neuropathy with various severe and complex diseases. The therapeutic benefits of vitamins and further understanding of the mechanisms for vitamin treatment effects should be emphasized and highlighted. More clinical trials are needed to establish optimal treatment strategies for vitamins in the various neuropathies. A large range of people/patients screening for vitamin deficiencies may be considered in order to provide early diagnosis and timely medical assistance.

show abstract

Section: Vitamin Dmentioning

confidence: 89%

Section: Vitamin Dmentioning

confidence: 99%

Vitamins in neuropathy: pathophysiological and therapeutic roles

Chen,

Song

2023

Current Opinion in Neurology

View full text Add to dashboard Cite

show abstract

Causal relationships between COVID-19 and venous thromboembolism: A mendelian randomization analysis

Wang,

Wu,

Pan

et al. 2024

Phlebology

View full text Add to dashboard Cite

Objective: Observational studies show the correlation between COVID-19 and venous thromboembolism (VTE) risk. However, the causal effects remain uncertain. We aimed to explore the potential causal association between COVID-19 and VTE using Mendelian randomization (MR) design. Methods: Two-sample MR was used to evaluate the potential causality between COVID-19 and VTE by selecting single-nucleotide polymorphisms (SNPs) as instrumental variables (IVs) from genome-wide association studies (GWAS). The weighted median, MR-Egger, simple mode, and weighted mode were employed as supplementary methods for MR estimations, with the inverse-variance weighted (IVW) method serving as the principal analysis. In addition, we took sensitivity analyses, including Cochran’s test, MR-Pleiotropy Residual Sum and Outlier (MR-PRESSO), and leave-one-out analysis to ensure that we obtained stable and reliable results. Results: Our study selected 26 COVID-19 severity, 31 COVID-19 hospitalization, and 13 COVID-19 susceptibility SNPs as instrumental variables. The IVW analysis results revealed that there was no causal relationship between COVID-19 severity, hospitalization, or susceptibility and VTE, with odds ratios of 0.974 (95%CI: 0.936-1.013, p = 0.19), 0.976 (95%CI: 0.918-1.039, p = 0.447), and 0.908 (95%CI: 0.775-1.065, p = 0.235), respectively. The IVW approach yielded consistent results with MR-Egger, Weighted Median simple mode, and weighted mode. MR-PRESSO and sensitivity analysis further confirmed the stability and consistency of the MR results. Conclusions: This study did not find evidence to support a causal relationship between COVID-19 and VTE at the genetic level. Further investigation is warranted to determine if the significant association reported in previous observational studies between the two is due to confounding factors.

show abstract

Dietary patterns and diabetic microvascular complications risk: a Mendelian randomization study of European ancestry

Zhou,

Zheng,

Kong

et al. 2024

Front. Nutr.

View full text Add to dashboard Cite

PurposePrevious observational studies about the link between dietary factors and diabetic microvascular complications (DMCs) is controversial. Thus, we systemically assessed the potential causal relationship between diet and DMCs risk using Mendelian randomization (MR) methods.MethodsWe used genome-wide association studies (GWAS) statistics to estimate the causal effects of 17 dietary patterns on three common DMCs in European. Summary statistics on dietary intakes were obtained from the UK biobank, and data on DMCs [diabetic retinopathy (DR), diabetic nephropathy (DN), and diabetic neuropathy (DNP)] were obtained from the FinnGen Consortium. A two-sample MR (TSMR) was conducted to explore the causal relationships of dietary habits with DMCs. In addition, multivariable MR analysis (MVMR) was performed to adjust for traditional risk factors for eating habits, and evaluated the direct or indirect effects of diet on DMCs.ResultsTSMR analysis revealed that salad/raw vegetable intake (odd ratio [OR]: 2.830; 95% confidence interval [CI]: 1.102–7.267; p = 0.0306) and fresh fruit intake (OR: 2.735; 95% CI: 1.622–4.611; p = 0.0002; false discovery rate [FDR] = 0.0082) increased the risk of DR, whereas cheese intake (OR: 0.742; 95% CI: 0.563–0.978; p = 0.0339) and cereal intake (OR: 0.658; 95% CI: 0.444–0.976; p = 0.0374) decreased the risk of DR. Salad/raw vegetable (OR: 6.540; 95% CI: 1.061–40.300; p = 0.0430) and fresh fruit consumption (OR: 3.573; 95% CI: 1.263–10.107; p = 0.0164) are risk factors for DN, while cereal consumption (OR: 0.380; 95% CI: 0.174–0.833; p = 0.0156) is the opposite. And genetically predicted higher pork intake increased the risk of DNP (OR: 160.971; 95% CI: 8.832–2933.974; p = 0.0006; FDR = 0.0153). The MVMR analysis revealed that cheese intake may act as an independent protective factor for DR development. Moreover, fresh fruit intake, salad/raw vegetable intake and pork intake may be independent risk factors for DR, DN and DNP, respectively. Other causal associations between dietary habits and DMCs risk may be mediated by intermediate factors.ConclusionThis causal relationship study supports that specific dietary interventions may reduce the risk of DMCs.

show abstract

Causal association between vitamin D and diabetic neuropathy: a Mendelian randomization analysis

Cited by 3 publications

References 61 publications

Vitamins in neuropathy: pathophysiological and therapeutic roles

Vitamins in neuropathy: pathophysiological and therapeutic roles

Causal relationships between COVID-19 and venous thromboembolism: A mendelian randomization analysis

Dietary patterns and diabetic microvascular complications risk: a Mendelian randomization study of European ancestry

Contact Info

Product

Resources

About