Causal Association of Coffee Consumption and Total, Knee, Hip and Self-Reported Osteoarthritis: A Mendelian Randomization Study

Zhang, Yangchang; Fan, Jun; Chen, Li; Xiong, Yang; Wu, Tingting; Shen, Shisi; Wang, Xu; Meng, Xuchen; Lu, Yanjun; Lei, Xun

doi:10.3389/fendo.2021.768529

Cited by 20 publications

(23 citation statements)

References 48 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…One study discovered that individuals who consumed 2 to 4 cups of coffee daily exhibited lower levels of TSH concentrations. [5] However, it is important to note that this study did not establish a significant association between coffee consumption and the risk of developing hypothyroidism and hyperthyroidism. On the contrary, participation in physical exercise has been shown to have positive effects on individuals with hypothyroidism.…”

Section: Discussionmentioning

confidence: 58%

Adherence to thyroid therapy and depressive status among patients with hypothyroidism in the northern of Jordan: A cross-sectional study

Alhemedi,

Qasaimeh,

Alzoubia

et al. 2024

Medicine

View full text Add to dashboard Cite

Hypothyroidism is a chronic and progressive medical condition that requires extreme adherence to medication in order to effectively manage the disease. The aim of this study was to examine patients’ adherence to their thyroid therapy and their depressive status and their associated predictors. This is a cross-sectional study that was conducted between April and June 2023 using a sample of chronic hypothyroidism patients visiting the Jordan University of Science and Technology Health Center in Irbid, along with the Family Medicine and Endocrine clinic at King Abdullah University Hospital. The 8-item Morisky Medication Adherence Scale (MMAS-8) and Patient Health Questionnaire (PHQ)-2 were used to examine patients’ adherence level and mental status. A total of 296 patients were involved in this study. Around 35.5% of the patients found to have high level of adherence. Around 27.4% of the patients demonstrated a low level of adherence. The mean PHQ-2 score for the study sample was 2.00 (SD: 1.7) out of 6. Using a cutoff point of 3, we identified that 29.7% of the patients are at risk of developing major depressive disorder. Patients aged 31 to 50 years and married patients were identified to have higher adherence level compared to other patients (P < .05). This study observed a notable low to moderate level of adherence among patients diagnosed with hypothyroidism in Jordan with regards to their prescribed therapeutic regimen. Furthermore, a significant part of the individuals had a susceptibility to the development of major depressive disorder.

show abstract

Section: Discussionmentioning

confidence: 58%

Adherence to thyroid therapy and depressive status among patients with hypothyroidism in the northern of Jordan: A cross-sectional study

Alhemedi,

Qasaimeh,

Alzoubia

et al. 2024

Medicine

View full text Add to dashboard Cite

show abstract

“…The SNPs extracted from exposures (CHD, heart failure, stroke, IHD, and atrial fibrillation) were filtered by the following criteria: P < 5 × 10 –8 and linkage disequilibrium r 2 < 0.01 at a window size of 1 Mb. Further, the MR-Steiger method was performed on the left SNPs to calculate the variance explained by the exposure and outcome ( 18 ). The insignificant results of MR-Steiger indicated that the left SNPs may affect the outcome (i.e., ED) more than the exposure (i.e., CHD).…”

Section: Methodsmentioning

confidence: 99%

Causal association between cardiovascular diseases and erectile dysfunction, a Mendelian randomization study

Liu²,

Ren³

et al. 2023

Front. Cardiovasc. Med.

View full text Add to dashboard Cite

BackgroundCardiovascular diseases (CVD), including coronary heart disease (CHD), heart failure, ischemic heart disease (IHD), and atrial fibrillation, are prevalent in the aged. However, the influence of CVD on ED is less investigated. This study was performed to clarify the causal association between CVD and ED.Materials and methodsGenome-wide association studies (GWAS) datasets targeting CHD, heart failure, IHD, and atrial fibrillation were downloaded to retrieve single nucleotide polymorphisms (SNPs). Further, single-variable Mendelian randomization and multivariable Mendelian randomization (MVMR) were adopted to explore the causal association between CVD and ED.ResultsGenetically predicted CHD and heart failure were found to increase the risks of ED (OR = 1.09, P < 0.05 and OR = 1.36, P < 0.05, respectively). However, no causal association was disclosed among IHD, atrial fibrillation and ED (all P > 0.05). These findings remained consistent in sensitivity analyses. After controlling for body mass index, alcohol, low density lipoprotein, smoking and total cholesterol levels, the results of MVMR support the causal role of CHD on ED (P < 0.05). Similarly, the direct causal effect estimates of heart failure on ED were significant in MVMR analyses (P < 0.05).ConclusionUsing genetic data, this study revealed that genetically predicted CHD and heart failure may predict better ED compared with atrial fibrillation and IHD. The results should be interpreted with caution and the insignificant causal inference of IHD still needs further verification in future studies.

show abstract

“…Therefore, individual SN P could be assessed for their influence on causal associations. The PhenoScanner database (version 2.0) was examined for each SNP ( 30 ) to determine whether existing risk factors have previously been associated with any significant associations ( P < 5 × 10 –8 ): BMI ( 31 , 32 ), previous knee injury ( 32 ), gout ( 33 ), coffee intake ( 12 ) for knee OA; Hip dysplasia ( 34 ), Steroids use ( 35 ), coffee intake ( 11 ) for hip OA; hypertension ( 33 ), diabetes, smoking ( 36 ) for RA; Vitamin D intake, Steroids use, smoking for OP ( 37 ). To rule out potential pleiotropic effects, we evaluated the effect of removing these SNPs from the MR estimations.…”

Section: Methodsmentioning

confidence: 99%

“…Habitual coffee consumption increases the incidence of OA ( 11 ), but not all joints. The effects of coffee were more prominent in knee OA, but not in the hip joint ( 12 ). Another Mendelian study found no causal effect of coffee consumption on the incidence of RA ( 13 ).…”

Section: Introductionmentioning

confidence: 99%

Causal Association Between Tea Consumption and Bone Health: A Mendelian Randomization Study

Chen

et al. 2022

Front. Nutr.

View full text Add to dashboard Cite

BackgroundMuch observational research reported that tea consumption decreases the risk of osteoarthritis (OA), rheumatoid arthritis (RA), and osteoporosis (OP) which are the three major bone disorders. However, the observed correlation is inconclusive. To determine the causal relationship between genetically predicted tea intake and OA, RA, and OP, we performed a two-sample Mendelian randomization (MR) study based on large samples.MethodsThe European population’s genome-wide association meta-analysis (GWAS) dataset identified SNPs associated with tea consumption was obtained from Neale Lab’s analysis of UK Biobank data that comprised 349,376 participants of European ancestry. We extracted genetic data for knee OA (17,885 controls and 4,462 cases), hip OA (50,898 controls and 12,625 cases), and RA (43,923 controls and 14,361 cases) from the UK Biobank and OP cases (93083 controls and 1,175 cases) from FinnGen Data Freeze 2. A MR study was conducted to examine the effect of selected single nucleotide polymorphisms (SNPs) and OA, RA, and OP risk. Several sensitivity analyses were performed with weighted median and inverse-variance weighted methods for estimating the causal effects.ResultsIn this MR study, the genetically predicted per one cup increase of tea consumption was not associated with knee OA (OR 1.11,95% CI: 0.79–1.55) using IVW with random effect. Genetic predisposition to tea consumption was not associated with hip OA (OR: 1.20, 95% CI: 0.84–1.71), RA (OR: 1.24 95% CI: 0.81–1.91), and OP (OR: 1.11, 95% CI: 0.89, 1.39). Following the sensitivity analysis, there was no potential pleiotropy.ConclusionAccording to our study, According to our study, there was no statistical power to confirm a causal relationship between tea consumption and the risk of knee OA, hip OA, RA, and OP.

show abstract

Causal Association of Coffee Consumption and Total, Knee, Hip and Self-Reported Osteoarthritis: A Mendelian Randomization Study

Cited by 20 publications

References 48 publications

Adherence to thyroid therapy and depressive status among patients with hypothyroidism in the northern of Jordan: A cross-sectional study

Adherence to thyroid therapy and depressive status among patients with hypothyroidism in the northern of Jordan: A cross-sectional study

Causal association between cardiovascular diseases and erectile dysfunction, a Mendelian randomization study

Causal Association Between Tea Consumption and Bone Health: A Mendelian Randomization Study

Contact Info

Product

Resources

About