2024
DOI: 10.21203/rs.3.rs-4454204/v1
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Causal association of immune cell phenotypes with osteosarcoma and the mediation role of blood metabolites: A two-steps, two-samples Mendelian randomization study

Chicheng Niu,
Qingyuan Xu,
Weiwei Wang
et al.

Abstract: Background: Immunogenic nature of osteosarcoma is well-established, but the precise roles of immune cells and the potential influence of blood metabolites on its advancement remain unclear. Methods: Two-step, two-sample Mendelian randomization (MR) strategy was employed to investigate causal relation between osteosarcoma risk and immune cell distribution, we sought to uncover and measure the potential mediating role of blood metabolites. Our analysis incorporated a diverse range of MR estimation techniques, en… Show more

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