Causal associations of education, lifestyle behaviors, and cardiometabolic traits with epigenetic age acceleration: a Mendelian randomization study

Kong, Lijie; Ye, Chaojie; Wang, Yiying; Zheng, Jie; Wang, Shuangyuan; Lin, Hong; Zhao, Zhongwei; Li, Mian; Xu, Yu; Lu, Jieli; Chen, Yuhong; Xu, Min; Wang, Weiqing; Ning, Guang; Bi, Yufang; Wang, Tiange

doi:10.1101/2022.07.12.22277528

Cited by 1 publication

(1 citation statement)

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“… 38 Even when accounting for body mass index and body fat percentage, waist circumference remained associated with insulin sensitivity in a population of adults aged 50 to 95 years. 38 In a study of 34 710 European adults, higher waist circumference was identified as a causal risk factor for accelerated epigenetic age, 39 adding to the existing literature on waist circumference and epigenetic age. 40 To our knowledge, there are no existing longitudinal studies examining waist circumference as a mediator between childhood stress and accelerated biological age.…”

Section: Introductionmentioning

confidence: 99%

Psychosocial Disadvantage During Childhood and Midlife Health

Brown,

Alegria,

Hamlat

et al. 2024

JAMA Netw Open

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ImportanceLow childhood socioeconomic status (SES) is a social hallmark of aging that contributes to adult health disparities and earlier morbidity and mortality. Childhood perceptions of stress are associated with child health outcomes and may contribute to premature biological aging into adulthood.ObjectiveTo describe the association of childhood SES and perceived stress with midlife insulin resistance and epigenetic age and to explore whether late adolescent adiposity mediates the observed associations.Design, Setting, and ParticipantsThe longitudinal cohort National Heart, Lung, and Blood Institute Growth and Health Study enrolled girls aged 10 years from January 1987 to May 1988, and followed them up to 19 years of age. Participants from Richmond, California, were recruited again at midlife in 2016 to assess insulin resistance and epigenetic age. Analyses were conducted from August 2, 2023, to March 18, 2024. A total of 433 participants were eligible and included in the analyses (specific sample sizes ranged across analyses from 303 to 391).ExposuresChildhood levels of SES at 10 years of age (parental educational level and income) and perceived stress at 11 years of age.Main Outcomes and MeasuresThe hypotheses tested were formulated after data collection. Outcomes included the homeostatic model assessment of insulin resistance (HOMA-IR) and the GrimAge and DunedinPACE epigenetic clocks. Waist circumference in late adolescence was tested as a mediator.ResultsAmong the 433 participants, the mean (SD) age was 39.4 (1.2) years; 218 (50.3%) were Black and 215 (49.7%) were White; and 135 (31.2%) had parents with a college degree or higher. Higher parental educational level was associated with lower HOMA-IR (B = −0.22 [95% CI, −0.41 to −0.02]; P = .03), lower midlife GrimAge (B = −1.76 [95% CI, −2.85 to −0.66] years; P = .002), and slower midlife DunedinPACE (B = −0.03 [95% CI, −6.29 to −0.002]; P = .04). Childhood perceived stress was indirectly associated through late adolescent adiposity with midlife HOMA-IR (B = 0.01 [95% CI, 0.001-0.01]; P = .02) and midlife GrimAge (B = 0.02 [95% CI, 0.003-0.04] years; P = .01).Conclusions and RelevanceIn this longitudinal cohort study of midlife health and aging, childhood social hallmarks of aging were associated with midlife insulin resistance and epigenetic age (GrimAge and DunedinPACE). Future studies should identify malleable factors that may slow the impact of social hallmarks of aging.

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