Causal effect of gut microbiota on Gastroduodenal ulcer: a two-sample Mendelian randomization study

Abstract

BackgroundGastroduodenal ulcers are associated with Helicobacter pylori infection and the use of nonsteroidal anti-inflammatory drugs (NSAIDs). However, the causal relationship between gastroduodenal ulcers and gut microbiota, especially specific gut microbiota, remains unclear.MethodsWe conducted an analysis of published data on the gut microbiota and Gastroduodenal ulcer using genome-wide association studies (GWAS). Two-sample Mendelian randomization (MR) analysis was performed to determine the causal relationship between gut microbiota and Gastroduodenal ulcer. Sensitivity, heterogeneity, and pleiotropy analyses were conducted to confirm the accuracy of the research findings.ResultsOur study showed that the abundance of Enterobacteriaceae, Butyricicoccus, Candidatus Soleaferrea, Lachnospiraceae NC2004 group, Peptococcus, and Enterobacteriales was negatively correlated with the risk of Gastroduodenal ulcer. Conversely, the abundance of Streptococcaceae, Lachnospiraceae UCG010, Marvinbryantia, Roseburia, Streptococcus, Mollicutes RF9, and NB1n was positively correlated with the risk of Gastroduodenal ulcer. MR analysis revealed causal relationships between 13 bacterial genera and Gastroduodenal ulcer.ConclusionThis study represents a groundbreaking endeavor by furnishing preliminary evidence regarding the potentially advantageous or detrimental causal link between the gut microbiota and Gastroduodenal ulcer, employing Mendelian Randomization (MR) analysis for the first time. These discoveries have the potential to yield fresh perspectives on the prevention and therapeutic approaches concerning Gastroduodenal ulcer, with a specific focus on the modulation of the gut microbiota.

Exposure to Microcystin-LR Promotes Colorectal Cancer Progression by Altering Gut Microbiota and Associated Metabolites in APCmin/+ Mice

“…Specifically, we found that in APC min/+ mice with subchronic exposure to MC-LR, the abundance of Marvinbryantia, Gordonibacter and Family_XIII_AD3011_group was increased, while that of Faecalibaculum, Lachnoclostridium, Bifidobacterium and Turicibacter was significantly decreased. Marvinbryantia was reported to be positively correlated with the risk of gastroduodenal ulcers [56]. Gordonibacter was increased in Western-style-diet-induced mice, which contributed to metabolic-associated fatty liver disease [57].…”

The causal relationship between gut microbiota and diabetic neuropathy: a bi-directional two-sample Mendelian randomization study

“…Previous studies have shown that delayed neurocognitive recovery was enriched by Anaerofilum compared to the non-delayed neurocognitive recovery group ( 42 ). The study of the relationship between Dorea and insomnia ( 43 ), Lachnospiraceae UCG-010 and chronic kidney disease ( 44 ), Ruminococcus_2 and rheumatoid arthritis ( 45 ), order NB1n and gastroduodenal ulcers ( 46 ) highlight the potential for GM-focused treatments.…”

Causal associations between gut microbiota and synovitis–tenosynovitis: a two-sample Mendelian randomization study

“…The WME approach weighted the causal effect of different genetic variants on traits and then took its median as the final causal effect estimate. Even when 50% of the weight was derived from invalid IVs, it could provide consistent estimates ( Bowden et al, 2016 ; Zhang et al, 2023 ). The WME estimation results are preferred when there is only heterogeneity but no pleiotropy.…”