Causal Effects of Genetically Predicted Cystatin C on Osteoporosis: A Two-Sample Mendelian Randomization Study

Yuan, Jiaqin; Luan, Fu-Jun; Li, Jie; Zhang, Jinglin; Jiang, Wei; Peng, Lipeng; Wang, Wenting

doi:10.3389/fgene.2022.849206

Cited by 5 publications

(3 citation statements)

References 37 publications

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“…29,30 A Mendelian randomization study of MR-Base and UK Biobank data showed significant correlations between serum cystatin C levels and osteoporosis. 5 According to a cross-sectional Korean study, serum cystatin C concentrations were inversely correlated with BMD among women, but not men. Women with a higher cystatin C level were more likely to have osteoporosis, whereas men did not show such a correlation.…”

Section: Discussionmentioning

confidence: 99%

“…1,2 As the population ages, osteoporosis is becoming more prevalent, 3,4 affecting approximately 200 million people worldwide. 5 Currently, osteoporosis is clinically indicated by measuring bone mineral density (BMD) through dual-energy X-ray absorptiometry (DXA). 6,7 However, further exploration of biomarkers related to bone health and density might aid in the early diagnosis, prevention, and treatment of osteoporosis.…”

Section: Introductionmentioning

confidence: 99%

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Association between the ratio of serum creatinine to cystatin C and bone mineral density in middle-aged and older adults: a cross-sectional study from NHANES database

Wang,

Du,

et al. 2023

J Int Med Res

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Objective To investigate the association between creatinine to cystatin C ratio (CCR) and bone mineral density (BMD) in middle-aged and older adults. Methods This cross-sectional study investigated participants aged 50–85, using National Health and Nutrition Examination Survey (NHANES) data from 1999 to 2002. The correlation between CCR and total BMD was assessed by multivariate linear regression models, using stratified analysis by age, sex and race (Mexican American, other Hispanic, non-Hispanic White, non-Hispanic Black, and other race) to distinguish various special populations. Results Among 2992 patients, multiple regression models revealed a significant positive correlation between CCR and total BMD: model 1, 0.030 (95% confidence interval [CI] 0.029, 0.031); model 2, 0.009 (95% CI 0.008, 0.010); model 3, 0.010 (95% CI 0.009, 0.013). After controlling for all covariates, a positive correlation was observed between CCR and total BMD in both men and women, and was further strengthened in older age groups. When stratifying by race, the positive correlation was most significant among ‘other Hispanic’ participants; there was no significant correlation among those of ‘other race’. Conclusions A positive correlation was demonstrated between CCR and total BMD in middle-aged and older adults aged 50–85 years, with the most significant positive correlation in the older ‘other Hispanic’ population. No significant correlation was observed among participants of ‘other race’.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Association between the ratio of serum creatinine to cystatin C and bone mineral density in middle-aged and older adults: a cross-sectional study from NHANES database

Wang,

Du,

et al. 2023

J Int Med Res

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“…Using the package twosampleMR (Yuan et al, 2022) in R software, all analyses were conducted. According to the P-value of 5 × 10 −8 , the SNPs (IVs) in the GWAS were identified.…”

Section: Statistical Analysismentioning

confidence: 99%

Circulating metabolites and depression: a bidirectional Mendelian randomization

et al. 2023

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BackgroundStudies have shown an association between depression and circulating metabolites, but the causal relationship between them has not been elucidated. The purpose of this study was to elucidate the causal relationship between circulating metabolites and depression and to explore the role of circulating metabolites in depression.MethodsIn this study, the top single-nucleotide polymorphisms (SNPs) associated with circulating metabolites (n = 24,925) and depression (n = 322,580) were obtained based on the publicly available genome-wide association study using two-sample Mendelian randomization (MR). SNP estimates were summarized through inverse variance weighted, MR Egger, weighted median, MR pleiotropy residual sum and outlier, and “leave-one-out” methods.ResultsApolipoprotein A-I (OR 0.990, 95% CI 981–0.999) and glutamine (OR 0.985, 95% CI 0.972–0.997) had protective causal effects on depression, whereas acetoacetate (OR 1.021, 95% CI 1.009–1.034), glycoproteins (OR 1.005, 95% CI 1.000–1.009), isoleucine (OR 1.013, 95% CI 1.002–1.024), and urea (OR 1.020, 95% CI 1.000–1.039) had an anti-protective effect on depression. Reversed MR showed no effect of depression on the seven circulating metabolites.ConclusionIn this study, MR analysis showed that apolipoprotein A-I and glutamine had a protective effect on depression, and acetoacetate, glycoprotein, isoleucine, glucose, and urea may be risk factors for depression. Therefore, further research must be conducted to translate the findings into practice.

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Causal effects of genetically determined circulating metabolites on endometriosis: A Mendelian randomization study

Liu,

Yin,

Liu

et al. 2024

Medicine

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Endometriosis (EMs) is a common gynecological disease accompanied by metabolic disturbances. However, the causality between metabolites and the risk of EMs remains unclear. We conducted a 2-sample Mendelian randomization (MR) analysis using the publicly available genome-wide association study (GWAS) of 486 circulating metabolites and EMs. The inverse variance weighted (IVW) was mainly used for assessing causality. MR–Egger intercept, MR-PRESSO Global, leave-one-out, and Cochran Q test analyses were used for sensitivity analyses. A total of 25 causal metabolites related to EMs have been identified, including 13 known and 12 unknown ones. Among the known metabolites, caffeine (OR = 0.86, 95% CI: 0.76–0.98, P = .026), cortisol (OR = 0.64, 95% CI: 0.41–0.99, P = .047), glycocholate (OR = 0.67, 95% CI: 0.51–0.87, P = .003), adrenate 22:4n6 (OR = 0.52, 95% CI: 0.35–0.77, P = .001), and ergothioneine (OR = 0.62, 95% CI: 0.47–0.81, P = .000) were protective factors for EMs, while mannose (OR = 1.43, 95% CI: 1.01–2.03, P = .044), 4-acetamidobutanoate (OR = 1.92, 95% CI: 1.27–2.89, P = .002), 1-linoleoylglycerol (OR = 1.36, 95% CI: 1.10–1.68, P = .005), bilirubin (Z, Z) (OR = 1.15, 95% CI: 1.01–1.31, P = .032), threonate (OR = 1.42, 95% CI: 1.14–1.77, P = .002), bilirubin (E, E) (OR = 1.18, 95% CI: 1.01–1.38, P = .039), erythronate (OR = 1.59, 95% CI: 1.01–2.52, P = .047), and dimethylarginine (SDMA + ADMA) (OR = 2.07, 95% CI: 1.19–3.62, P = .010) were risk factors for EMs. Additionally, there was no evidence of heterogeneity or pleiotropy of the known metabolites. Leave-one-out analysis indicated that the MR findings were robust. Our findings provide valuable circulating biomarkers as well as therapeutic targets for the screening, prevention, and treatment of EMs.

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Causal Effects of Genetically Predicted Cystatin C on Osteoporosis: A Two-Sample Mendelian Randomization Study

Cited by 5 publications

References 37 publications

Association between the ratio of serum creatinine to cystatin C and bone mineral density in middle-aged and older adults: a cross-sectional study from NHANES database

Association between the ratio of serum creatinine to cystatin C and bone mineral density in middle-aged and older adults: a cross-sectional study from NHANES database

Circulating metabolites and depression: a bidirectional Mendelian randomization

Causal effects of genetically determined circulating metabolites on endometriosis: A Mendelian randomization study

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