Causal effects of hypertension on risk of erectile dysfunction: A two-sample Mendelian randomization study

Wang, Zheng; Wang, Yunyun; Xiong, Jiachao; Gan, Xinxin; Bao, Yewei; Jiang, Aimin; Zhou, Ye; Huangfu, Zhao; Yang, Yiren; Li, Yong; Xia, Demeng; Wang, Linhui

doi:10.3389/fcvm.2023.1121340

Cited by 9 publications

(4 citation statements)

References 60 publications

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“…Связь между артериальной гипертензией и сексуальной дисфункцией. Аг является широко распространённым заболеванием и известным фактором риска сексуальной дисфункции как у мужчин, так и у женщин [25,26]. несмотря на неоспоримые успехи в развитии фармакологической терапии Аг и широкое назначение антигипертензивных препаратов, лишь небольшая часть пациентов достигает стабильного поддержания целевых уровней Ад [27].…”

Section: результатыunclassified

Sexual dysfunction in men and women with arterial hypertension

Kanorskii

2024

jour

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Sexual dysfunction is often associated with hypertension but is not recognized, reported, or adequately treated. Research on sexual dysfunction is sparse, which may be due to the taboo nature of the topic. A literature search was conducted in five databases (PubMed, Web of Science, Scopus, Cochrane Library and PsycINFO) to identify articles published over the past ten years (from 2014 to 2024), using the keywords “sexual dysfunction”, “arterial” hypertension", "antihypertensive drugs", "erectile dysfunction". The review examines the prevalence, pathophysiology, clinical manifestations of sexual dysfunction in men and women, its relationship with arterial hypertension, antihypertensive therapy, concomitant pathology, and possible methods of correction.

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Section: результатыunclassified

Sexual dysfunction in men and women with arterial hypertension

Kanorskii

2024

jour

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“…It utilizes genetic variants that are linked to the exposure of interest as instrumental variables (IVs) to establish the causal impact of the exposure on the outcome. This approach is effective in isolating the effect of exposures from potential confounding factors, such as environmental in uences and lifestyle choices [17][18][19][20][21]. It can reduce the impact of reverse causality to ensure maximum validity [22,23].…”

Section: Introductionmentioning

confidence: 99%

Investigating the Metabolomic Pathways in Female Reproductive Endocrine Disorders: A Mendelian Randomization Study

Lu,

Wang,

Yang

et al. 2024

Preprint

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Background Reproductive endocrine disorders (RED) including polycystic ovary syndrome (PCOS), endometriosis (EMs), and female infertility (FI), significantly affect women's health globally, with varying prevalence across different regions. These conditions can be addressed through medication, surgical interventions, and lifestyle modifications. However, the limited understanding of RED's etiology and the substantial economic burden of its treatment highlight the importance of investigating its pathogenesis. Metabolites play a critical role in metabolic processes and are potentially linked to the development of RED. Despite existing studies suggesting correlations between metabolites and RED, conclusive evidence remains scarce, primarily due to the observational nature of these studies, which are prone to confounding factors. Methods This study utilized Mendelian Randomization (MR) to explore the causal relationship between metabolites and RED, leveraging genetic variants associated with metabolite levels as instrumental variables to minimize confounding and reverse causality. Data were obtained from the Metabolomics GWAS Server and the IEU OpenGWAS project. Instrumental variables were selected based on their association with the human gut microbiota composition, and the GWAS summary statistics for metabolites, PCOS, EMs, and FI were analyzed. The MR-Egger regression and random-effects inverse-variance weighted (IVW) methods were employed to validate the causal relationship. Cochran's Q test was employed to evaluate heterogeneity, sensitivity analysis was performed using leave-one-out analysis, and for pleiotropy analysis, the intercept term of MR-Egger's method was investigated. Results The MR analysis revealed significant associations between various metabolites and RED conditions. For instance, a positive association was found between 1-palmitoylglycerophosphocholine and PCOS, while a negative association was noted between phenylacetate and FI. The study identified several metabolites associated with an increased risk and others with protective effects against PCOS, EMs, and FI. These findings highlight the complex interplay between metabolites and RED, suggesting potential pathways through which these conditions could be influenced or treated. Conclusion This MR study provides valuable insights into the causal relationship between metabolites and female reproductive endocrine disorders, suggesting that metabolic alterations play a significant role in the pathogenesis of PCOS, EMs, and FI, and offering a foundation for future research and therapeutic development.

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“…Mendelian Randomization (MR) offers a robust alternative to traditional epidemiological methods for causal inference, minimizing confounding and reverse causation ( Skrivankova et al, 2021 ; Verbanck et al, 2018 ; Thanassoulis and O'Donnell, 2009 ). MR has been widely applied in cardiovascular and cerebrovascular research, including studies on ICH ( Larsson et al, 2019 ; Titova et al, 2020 ; Xiao et al, 2022 ; Yu et al, 2022 ; Wang et al, 2023 ). This makes it an ideal tool for exploring the yet-to-be-established causal relationship between various emotional states and ICH.…”

Section: Introductionmentioning

confidence: 99%

Emotional dispositions and intracerebral hemorrhage: a Mendelian Randomization insight

Hou,

Xu,

Buaijier

et al. 2024

Front. Genet.

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BackgroundIntracerebral hemorrhage (ICH) is a severe form of stroke with high mortality and limited treatment options. While traditional risk factors like hypertension have been well-studied, the role of emotional states as acute triggers for ICH remains unclear. This study employs Mendelian Randomization (MR) to investigate the causal relationship between emotional traits of worry and anxiety and the incidence of ICH.MethodsWe used a two-sample MR approach, leveraging summary-level data from genome-wide association studies (GWAS) for emotional traits and ICH. The primary analysis was conducted using the Inverse-Variance Weighted (IVW) method, supplemented by multiple sensitivity analyses including Maximum Likelihood and MR PRESSO methods.ResultsOur MR analysis revealed a robust and significant causal relationship between the emotional trait “Worrier/anxious feelings” and ICH, supported by 195 instrumental variables (SNPs). The odds ratio (OR) was 2.98 (95% CI: 1.16, 7.61) with a p-value of 0.0229. Sensitivity analyses corroborated these findings, enhancing the reliability of our results. In contrast, other emotional traits such as “Nervous feelings” and “Sensitivity/hurt feelings” did not show significant associations, reinforcing the specificity of our primary finding.ConclusionOur study provides compelling evidence for a causal relationship between the emotional traits of worry and anxiety and the incidence of ICH, offering a new dimension in our understanding of this devastating condition and paving the way for more nuanced risk stratification and preventive strategies.

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Causal effects of hypertension on risk of erectile dysfunction: A two-sample Mendelian randomization study

Cited by 9 publications

References 60 publications

Sexual dysfunction in men and women with arterial hypertension

Sexual dysfunction in men and women with arterial hypertension

Investigating the Metabolomic Pathways in Female Reproductive Endocrine Disorders: A Mendelian Randomization Study

Emotional dispositions and intracerebral hemorrhage: a Mendelian Randomization insight

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