Causal effects of Sjögren's syndrome on cancer risk: A Mendelian Randomization Study

Abstract

Objective Previous studies have reported the association between sjögren's syndrome (SS) and some types of tumors. However, the causal associations between SS and different types of cancer remain inconclusive. This research aimed to assess the causal relationships between SS and cancer risk by the mendelian randomization (MR) analysis.Methods Two-sample MR analysis was performed by using the genome-wide association studies (GWAS) data and the FinnGen data. Qualified instrumental variables (IVs) were singled out based on the assumptions of MR analysis. The main method was the inverse-variance weighted (IVW). Sensitivity tests were also applied.Results Genetically determined SS has a causal effect on an increased risk of marginal zone lymphoma (IVW odds ratio (OR) = 1.9425, 95% confidence interval (CI): 1.5229–2.4776, P = 8.9E-08). Moreover, there was no causal effect between SS and other cancer risks in the MR analysis (IVW P > 0.05).Conclusions Our results investigated that genetically determined SS increases the risk of marginal zone lymphoma. During the treatment of SS, we should pay more attention on whether to appear the clinical symptoms of marginal zone lymphoma.