2023
DOI: 10.1101/2023.11.27.23299065
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Causality between Peripheral Immune Cell Counts and Membranous Nephropathy: A Bidirectional Mendelian Randomization Study

Zhihang Su,
Liu Wen,
Xiangning Feng
et al.

Abstract: BackgroundMembranous nephropathy (MN), an autoimmune disease, has not yet been fully elucidated regarding its relationship with immune cells.MethodsAs a primary method in this Mendelian randomization (MR) analysis, we employed the Inverse Variance Weighted (IVW), Wald Ratio (WR), Steiger filtering, Weighted Median, Weighted mode, MR-Egger, Mendelian randomization pleiotropy residual sum, and outlier (MR-PRESSO) and Leave-one-out sensitivity test. Reverse MR analysis was utilized to investigate whether MN affec… Show more

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