Causality of rhabdomyolysis and combined tetanus, diphtheria and acellular pertussis (Tdap) vaccine administration

Kulkarni, Hemant; Lenzo, Nat; McLean‐Tooke, Andrew

doi:10.1002/jcph.145

Cited by 5 publications

(2 citation statements)

References 13 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Acquired rhabdomyolysis is due to trauma and exertion, hypoxic injury, infections, hyperthermia, drugs, and toxins [2]. Influenza [3], recombinant zoster [4], tetanus toxoid [5], and combined tetanus, diphtheria, and acellular pertussis vaccination [6] can cause rhabdomyolysis. Adjuvants are commonly used in medical therapy, including in vaccines.…”

Section: Discussionmentioning

confidence: 99%

“…Rhabdomyolysis is caused by the breakdown and necrosis of muscle tissue and the release of intracellular content into the bloodstream. There are multiple and diverse causes of rhabdomyolysis [2], including various types of vaccinations [3][4][5][6]. Interleukin (IL)-6 and IL-1β concentrations were reported to be increased in a patient with exertional rhabdomyolysis [7], and the IL-6 concentration was increased in a patient with rhabdomyolysis and coronavirus disease 2019 (COVID-19) [8].…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Recurring Weakness in Rhabdomyolysis Following Pfizer–BioNTech Coronavirus Disease 2019 mRNA Vaccination

2022

View full text Add to dashboard Cite

Rhabdomyolysis is a well-known clinical syndrome of muscle injury. Rhabdomyolysis following coronavirus disease 2019 (COVID-19) vaccination has recently been reported. The patients’ weakness gradually subsided and did not recur. Rhabdomyolysis associated with COVID-19 vaccination has not been assessed by repeated magnetic resonance imaging (MRI) within a short time. We report a rare case of an older woman who developed recurring weakness with rhabdomyolysis after COVID-19 vaccination. A 76-year-old woman presented with myalgia 2 days after receiving a third dose of the COVID-19 vaccine. A physical examination showed weakness of the bilateral iliopsoas muscles. Her creatine kinase concentration was 9816 U/L. MRI showed hyperintensity of multiple limb muscles. She was treated with intravenous normal saline. Her symptoms disappeared within 3 days. However, MRI on day 4 of hospitalization showed exacerbation of the hyperintensity in the left upper limb muscles. On day 5 of hospitalization, weakness of the left supraspinatus and deltoid muscles appeared. MRI on day 8 of hospitalization showed attenuation of the hyperintensity in all muscles. Her weakness and elevated creatine kinase concentration disappeared by day 10. Repeated MRI over a short time may be useful to predict potential weakness and monitor the course of COVID-19 vaccine-induced rhabdomyolysis.

show abstract