Causative Factors and Type of Anaemia Developed in Rabbits Following Chronic Consumption of Thermally Oxidized Palm Oil Diet

Ani, E. J.; Owu, Daniel U.; Osim, E. E.

doi:10.3923/jms.2015.61.70

Cited by 1 publication

(1 citation statement)

References 17 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…This claim is also supported by the study of Idoko et al, 30 who found that bleaching of palm oil contributes greatly to the destruction of its primary antioxidants. This submission is further given credence to by Ani et al, 31,32 that the consumption of thermally oxidized palm oil contributed greatly in the reduction of haematological parameters, increase in serum creatinine and urea as well as increased anaemia.…”

Section: Resultsmentioning

confidence: 66%

Attenuation of Oxidative Enzymes Induction in Palm Oil Fractions Pre-treated Cadmium Intoxicated Rats

Ichipi-Ifukor¹,

Asagba²,

Kweki³

et al. 2019

TJNPR

View full text Add to dashboard Cite

Impairing the toxic effects of cadmium (Cd) by diet induced antioxidant defence systems is an innovative approach to managing cadmium poisoning. The present study investigated the ability of crude palm oil (Elaeis guinensis) and its fractions to prevent the induction of aldehyde and sulphite oxidative enzymes in acute cadmium intoxicated male rats. The study comprised of six groups, which had group A as control, B as cadium group and C-F as test groups. Group A received No Cadmium and no Palm oil fraction, Group B received 20mgCd/Kg body weight, Groups C-F received 5ml/Kg body weight of appropriate palm oil fraction namely crude palm oil (CPO), Silica Gel Extract (SGE), Bleached Palm oil and unsaponifiable extract for 28 days prior to a single dose of cadmium in form of cadmium chloride on day 29 (20mgCd/Kg body weight). Rats were sacrificed 12h, 24h and 48h post-cadmium administration and the activities of aldehyde oxidase (AO) and sulphite oxidase (SO) were determined. Results obtained indicate a significant rise in AO and SO activities in the liver, kidney, heart, muscle tissues and serum between 12-48 hours following Cd administration compared to control. Administration of palm oil extracts caused significant reduction (p<0.05) in AO and SO activities. Results indicate that acute Cd administration induces the expression of oxidative enzyme within 12 hours but pre-treatment of rats with palm oil and its fractions reduces their expression.

show abstract

Section: Resultsmentioning

confidence: 66%