Cause and control of Radix Ophiopogonis browning during storage

Wang, Hui; Qi, Jin; Han, Dongqi; Xu, Tian; Liu, Jihua; Qin, Min-Jian; Zhu, Daling; Yu, Boyang

doi:10.1016/s1875-5364(15)60010-3

Cited by 3 publications

(3 citation statements)

References 22 publications

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“…In tropical and subtropical areas in particular (Zhang et al 2012), high temperatures and increased humidity are conducive for fungal growth and mycotoxin production. Mildew can degrade or destroy the active ingredients and produce toxic compounds, which reduces the efficacy of medicinal plants, and influences the quality and safety of their final products (Wang et al 2015). Aspergillus and Fusarium fungi, including Aspergillus flavus, have been reported as the most common species of fungi in medicinal plants (Battilani et al 2016).…”

Section: Introductionmentioning

confidence: 99%

Quality evaluation of Alpinia oxyphylla after Aspergillus flavus infection for storage conditions optimization

et al. 2017

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In the storage of Alpinia oxyphylla, growth of mildew (especially toxic fungi, such as Aspergillus flavus) is a potential safety risk. Few reports have investigated how A. oxyphylla storage conditions impact mold growth or how mold growth impacts the bioactive components of A. oxyphylla. In this study, sterilized A. oxyphylla samples were contaminated by artificial inoculation of A. flavus spores. The main chemical components and aflatoxin levels in the infected A. oxyphylla samples were characterized. Central composite design-response surface methodology was used to study the effects of different temperature and humidity of storage conditions on the fungal growth in A. oxyphylla and accumulation of aflatoxins. The results showed that aflatoxins levels can be minimized by storing samples at temperatures below 25 °C and with humidity less than 85%. Additionally, we found that the yield and composition of volatile oil in A. oxyphylla exhibited small changes due to mold growth. However, polysaccharide content reduced remarkably. Temperatures below 25 °C and humidity below 85% were the best storage conditions to preventing A. oxyphylla from becoming moldy. Our results provide the theoretical basis for future studies the effects of storage conditions and mold growth on the quality and safety of traditional Chinese medicines (TCMs).Electronic supplementary materialThe online version of this article (doi:10.1186/s13568-017-0450-x) contains supplementary material, which is available to authorized users.

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Section: Introductionmentioning

confidence: 99%

Quality evaluation of Alpinia oxyphylla after Aspergillus flavus infection for storage conditions optimization

et al. 2017

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“…Among the ingredients of Ginseng Radix, only panaxatriol inhibited intestinal NFO activity, and this effect was mild. Methylophiopogonanone A is an ingredient found in Ophiopogonis Radix [ 35 ], and it inhibits both hepatic and intestinal NFO activity. By increasing their concentrations to 100 μM, arctigenin and ruscogenin inhibited NFO activity by no more than 50%.…”

Section: Resultsmentioning

confidence: 99%

Effect of repeated Shengmai-San administration on nifedipine pharmacokinetics and the risk/benefit under co-treatment

Wang¹,

Tan²,

Chiang³

et al. 2022

Journal of Food and Drug Analysis

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Herbal interactions with nifedipine/felodipine through cytochrome P450 (CYP) 3A inhibition is significant in humans. Shengmai-San (SMS), a three-herbal formula of Chinese medicine, is commonly prescribed in Asia populations for cardiovascular disorders. This study aimed to elucidate the impact of SMS on nifedipine/felodipine treatment by the findings from rat pharmacokinetic study of nifedipine to the retrospective cohort study of patients with hypertension. The 3-week SMS treatment increased the systemic exposure to nifedipine by nearly two-fold and decreased nifedipine clearance by 39% in rats. Among the ingredients of SMS component herbs, schisandrin B, schisantherin A, and methylophiopogonanone A, inhibited the nifedipine oxidation (NFO) activities of rat hepatic and intestinal microsomes, as well as human CYP3A4. Methylophiopogonanone A was identified as a time-dependent inhibitor of CYP3A4. After 1:5 propensity score matching, 4,894 patients with nifedipine/felodipine use were analyzed. In patients receiving nifedipine/felodipine, the subgroup with concurrent SMS treatment had a higher incidence of headache (92.70 per 1,000 personyears) than the subgroup without SMS treatment (51.10 per 1,000 person-years). There was a positive association between headache incidence and cumulative doses of SMS (1–60 g SMS: hazard ratio (HR): 1.39; 95% confidence interval (CI): 1.11–1.74; >60 g SMS: HR: 1.97; 95% CI: 1.62–2.39; p < 0.0001). However, patients who had higher cumulative SMS doses had a lower risk of all-cause mortality (1–60 g SMS: HR: 0.67; 95% CI: 0.47–0.94; >60 g SMS: HR: 0.54; 95% CI: 0.37–0.79; p = 0.001). Results demonstrated increased rat plasma nifedipine levels after 3-week SMS treatment and increased headache incidence should be noted in nifedipine/felodipine-treated patients with prolonged SMS administration.

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“…In terms of characters, the surface of spoiled Ophiopogonis Radix will have holes caused by worms, or the surface color will become dark and black, the texture of spoiled Ophiopogonis Radix will become soft, and its smell will also change. Studies have shown that spoiled TCM produce antinutritional and toxic compounds, which may lead to the loss in nutritional quality, and further influence the safety of the final products (Wang et al., 2015).…”

Section: Introductionmentioning

confidence: 99%

Identification of changes in volatile organic compounds in Ophiopogonis Radix containing spoiled products in different proportions by headspace‐gas chromatography‐ion mobility spectrometry

Jia

Ye²,

Cuifen

et al. 2021

Journal of Food Biochemistry

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Ophiopogonis Radix is a kind of traditional Chinese medicine as well as a type of functional food. Because Ophiopogonis Radix grows in the ground, it is often damaged by worms during planting or broken when people try to dig them out, which leads to the containments of spoiled products of different proportion in Ophiopogonis Radix. Volatile organic compounds (VOCs) in Ophiopogonis Radix, which involves spoiled products in different proportions, were analyzed by headspace‐gas chromatography‐ion mobility spectrometry (HS‐GC‐IMS). Finally, a total of 87 VOCs were discovered after analysis, and 14 of them were chose to established characteristic fingerprints. Twelve of the 14 characteristic compounds were be recognized by a built‐in database. The results showed that the content of hexanol, ethanol, methanol, (E)‐2‐hexenal, and hexanal was in inverse proportion with the containing of spoiled products, so they may be characteristic VOCs of fresh Ophiopogonis Radix,; and the content of 3‐methy‐1‐butanol, furfural, 5‐methylfural, phenylacetaldehyde, 2‐methylbutanoic acid, 2‐butanone, and 2‐acetylfuran are proportional to the containing of spoiled products, so they may be the characteristic of VOCs of spoiled Ophiopogonis Radix. The signal peak intensities of the 14 characteristic VOCs were used as the variables of principal component analysis (PCA). The result shows that the fresh Ophiopogonis Radix and the spoiled Ophiopogonis Radix could be clearly differentiated, and the different proportions of spoiled products were grouped into separate categories, respectively. The larger the proportion of spoiled products, the greater the difference between the sample and fresh Ophiopogonis Radix. Practical applications Ophiopogonis Radix is a kind of commonly used traditional Chinese medicine and functional food. In the actual use of Ophiopogonis Radix, the damage caused by worms during planting and the breakage during being dug out often lead to Ophiopogonis Radix containing spoiled products in the market. The existence of spoiled products greatly affects the quality and safety of Ophiopogonis Radix. Due to the difference in flavor between fresh Ophiopogonis Radix and spoiled products, the present study used HS‐GC‐IMS method to analyze the VOCs in fresh Ophiopogonis Radix and Ophiopogonis Radix containing spoiled products of different proportions and screened out the characteristic VOCs of fresh Ophiopogonis Radix and spoiled Ophiopogonis Radix. The results provide scientific basis for quality control of Ophiopogonis Radix.

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Cause and control of Radix Ophiopogonis browning during storage

Cited by 3 publications

References 22 publications

Quality evaluation of Alpinia oxyphylla after Aspergillus flavus infection for storage conditions optimization

Quality evaluation of Alpinia oxyphylla after Aspergillus flavus infection for storage conditions optimization

Effect of repeated Shengmai-San administration on nifedipine pharmacokinetics and the risk/benefit under co-treatment

Identification of changes in volatile organic compounds in Ophiopogonis Radix containing spoiled products in different proportions by headspace‐gas chromatography‐ion mobility spectrometry

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