Cause–effect? Understanding the risk factors associated with bladder cancer

Bachir, Bassel G.; Kassouf, Wassim

doi:10.1586/era.12.140

Cited by 16 publications

(23 citation statements)

References 24 publications

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“…4a). This result was confirmed by quantitative analysis of the ecto-5′-NT/CD73 immunofluorescence, which increased in a time-response profile of BBN exposition (4,8,12,18, and 24 weeks). Moreover, it was observed that an increase in the areas of increased cell proliferation and decreased presence of umbrella cells are important pathological characteristics of a malignant bladder process.…”

Section: Pathological Analysissupporting

confidence: 56%

“…In this work, bladder cancer was induced by the addition of 0.05 % of BBN in the drinking water for 4,8,12,18, and 24 weeks with a respective control group for each induction time. The number of mice per group was 8 for control groups of 4, 8, and 12 weeks and 9, 10, and 10 for BBN groups of 4, 8, and 12 weeks, respectively; and for the cancer induction times of 18 and 24 weeks, it was 3 for control groups and 5 and 4 for groups that received BBN, respectively.…”

Section: Bladder Cancer Inductionmentioning

confidence: 99%

“…Macroscopically, the bladders of animals that received BBN had thicker walls than that of control animals. Figure 1 shows the bladder wet weight in different times of bladder cancer induction where animals that received BBN for 4 and 8 weeks had a significant increase in bladder weight in comparison with their respective control groups [F (1,57) =44.96, p<0.0001] without difference between different times of bladder cancer induction [F (4,57) =1.361, p=0.26]. For example, the bladder weight of control (healthy) animals killed at 4 weeks, was 103±22 mg of bladder/100 g animal, while the bladder weight of animals which received BBN for 4 weeks was 166±28 mg of bladder/100 g of animal.…”

Section: Mouse Bladder Cancer Induction By Bbn Expositionmentioning

confidence: 99%

“…It is the seventh most common cancer worldwide with about 336,000 new cases per year [3]. The main risk factors are smoking, which increase the risk up to six times, and occupational and environmental exposure to carcinogens [4,5]. About 90 % of bladder cancer corresponds to transitional cell carcinoma (TCC) [1,6] due to the fact that urothelium is constantly exposed to potential carcinogens [7].…”

Section: Introductionmentioning

confidence: 99%

“…However, nearly 70 % of patients present tumor recurrence, where 30 % of the recurrent tumors progress to muscle-invasive disease within 5 years of TUR [8,10]. Given the high recurrence rates and the need for frequent monitoring, this disease is one of the most expensive cancers to treat on a per patient basis from diagnosis until death [11], and hence, poses a tremendous burden on health systems worldwide [4]. Therefore, new therapeutic targets, which end up in more efficient treatments, are necessary to prevent bladder cancer recurrence and progression.…”

Section: Introductionmentioning

confidence: 99%

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NTPDase3 and ecto-5′-nucleotidase/CD73 are differentially expressed during mouse bladder cancer progression

Rockenbach

Braganhol

Dietrich

et al. 2014

Purinergic Signalling

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According to the World Health Organization, bladder cancer is the seventh most common cancer among men in the world. The current treatments for this malignancy are not efficient to prevent the recurrence and progression of tumors. Then, researches continue looking for better therapeutic targets which can end up in new and more efficient treatments. One of the recent findings was the identification that the purinergic system was involved in bladder tumorigenesis. The ectonucleotidases, mainly ecto-5′-nucleotidase/CD73 have been revealed as new players in cancer progression and malignity. In this work, we investigated the NTPDase3 and ecto-5′-nucleotidase/CD73 expression in cancer progression in vivo. Bladder tumor was induced in mice by the addition of 0.05 % of N-butyl-N-(hydroxybutyl)-nitrosamine (BBN) in the drinking water for 4, 8, 12, 18, and 24 weeks. After this period, mice bladders were removed for histopathology analysis and immunofluorescence assays. The bladder of animals which has received BBN had alterations, mainly inflammation, in initial times of tumor induction. After 18 weeks, mice's bladder has developed histological alterations similar to human transitional cell carcinoma. The cancerous urothelium, from mice that received BBN for 18 and 24 weeks, presented a weak immunostaining to NTPDase3, in contrast to an increased expression of ecto-5′-nucleotidase/CD73. The altered expression of NTPDase3 and ecto-5′-nucleotidase/ CD73 presented herein adds further evidence to support the idea that alterations in ectonucleotidases are involved in bladder tumorigenesis and reinforce the ecto-5′-nucleotidase/ CD73 as a future biomarker and/or a target for pharmacological therapy of bladder cancer.

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Section: Pathological Analysissupporting

confidence: 56%

Section: Bladder Cancer Inductionmentioning

confidence: 99%

Section: Mouse Bladder Cancer Induction By Bbn Expositionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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NTPDase3 and ecto-5′-nucleotidase/CD73 are differentially expressed during mouse bladder cancer progression

Rockenbach

Braganhol

Dietrich

et al. 2014

Purinergic Signalling

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Prediction of recurrence risk in patients with non-muscle-invasive bladder cancer

Ahmadi,

Shafee,

Moudi

2024

Asian Journal of Urology

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The association between physical activity and bladder cancer: systematic review and meta-analysis

et al. 2014

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Background:Physical activity may protect against bladder cancer through several biologic pathways, such as enhanced immune function and decreased chronic inflammation. Physical activity may also indirectly prevent bladder cancer by reducing obesity. A sizeable number of epidemiologic studies have examined the association between physical activity and bladder cancer, but the available evidence has not yet been formally summarised using meta-analysis.Methods:We performed a systematic literature review and meta-analysis of English-language studies published from January 1975 through November 2013. We followed the PRISMA guidelines and used a random effects model to estimate the summary risk estimates for the association between physical activity and bladder cancer.Results:A total of 15 studies with 5 402 369 subjects and 27 784 bladder cancer cases were included. High vs low levels of physical activity were related to decreased bladder cancer risk (summary relative risk (RR)=0.85, 95% confidence interval (CI)=0.74–0.98; I2=83% P-value for heterogeneity across all studies<0.001). Results were similar for cohort studies (RR=0.89, 95% CI=0.80–1.00; I2=64%) and case–control studies (RR=0.71, 95% CI=0.43–1.16; I2=87% P-value for difference=0.108) and they were comparable for women (RR=0.83, 95% CI=0.73–0.94; I2=0%) and men (RR=0.92, 95% CI=0.82–1.05; I2=67; P-value for difference=0.657). Findings were also comparable for recreational (RR=0.81, 95% CI=0.66–0.99; I2=77%) and occupational physical activity (RR=0.90, 95% CI=0.76–1.0; I2=76% P-value for difference=0.374), and they were largely consistent for moderate (RR=0.85, 95% CI=0.75–0.98; I2=76%) and vigorous activity (RR=0.80, 95% CI=0.64–1.00;I2=87% P-value for difference=0.535).Conclusions:Physical activity is associated with decreased risk of bladder cancer. Further studies are required to assess the relations of intensity, frequency, duration, and timing in life of physical activity to bladder cancer risk.

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Cause–effect? Understanding the risk factors associated with bladder cancer

Cited by 16 publications

References 24 publications

NTPDase3 and ecto-5′-nucleotidase/CD73 are differentially expressed during mouse bladder cancer progression

NTPDase3 and ecto-5′-nucleotidase/CD73 are differentially expressed during mouse bladder cancer progression

Prediction of recurrence risk in patients with non-muscle-invasive bladder cancer

The association between physical activity and bladder cancer: systematic review and meta-analysis

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