Cause of death in adults with congenital heart disease — An analysis of the German National Register for Congenital Heart Defects

Engelings, Claudia C.; Helm, P.; Abdul‐Khaliq, Hashim; Asfour, Boulos; Bauer, Ulrike; Baumgartner, Helmut; Kececioglu, Deniz; Körten, Marc-André; Diller, Gerhard‐Paul; Tutarel, Oktay

doi:10.1016/j.ijcard.2016.02.133

Cited by 161 publications

(76 citation statements)

References 19 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…17 The number of adult patients with >2 noncardiac comorbidities associated with a hospitalization with CHD almost doubled between 1998 and 2010. 18 In a study of 342 adult CHD (ACHD) admissions to an intensive care unit, abnormal thyroid, creatinine, and bilirubin tests were highly predictive of both intensive care unit and hospital mortality.…”

Section: Overviewmentioning

confidence: 99%

Diagnosis and Management of Noncardiac Complications in Adults With Congenital Heart Disease: A Scientific Statement From the American Heart Association

Lui¹,

Saïdi²,

Bhatt³

et al. 2017

Circulation

180

136

View full text Add to dashboard Cite

ABSTRACT:Life expectancy and quality of life for those born with congenital heart disease (CHD) have greatly improved over the past 3 decades. While representing a great advance for these patients, who have been able to move from childhood to successful adult lives in increasing numbers, this development has resulted in an epidemiological shift and a generation of patients who are at risk of developing chronic multisystem disease in adulthood. Noncardiac complications significantly contribute to the morbidity and mortality of adults with CHD. Reduced survival has been documented in patients with CHD with renal dysfunction, restrictive lung disease, anemia, and cirrhosis. Furthermore, as this population ages, atherosclerotic cardiovascular disease and its risk factors are becoming increasingly prevalent. Disorders of psychosocial and cognitive development are key factors affecting the quality of life of these individuals. It is incumbent on physicians who care for patients with CHD to be mindful of the effects that disease of organs other than the heart may have on the well-being of adults with CHD. Further research is needed to understand how these noncardiac complications may affect the long-term outcome in these patients and what modifiable factors can be targeted for preventive intervention.

show abstract

Section: Overviewmentioning

confidence: 99%

Diagnosis and Management of Noncardiac Complications in Adults With Congenital Heart Disease: A Scientific Statement From the American Heart Association

Lui¹,

Saïdi²,

Bhatt³

et al. 2017

Circulation

180

136

View full text Add to dashboard Cite

show abstract

“…Mais il s'agit bien évident toujours d'événements traumatisants, d'autant qu'il semble possible de les éviter dans un certain nombre de cas par une bonne évaluation de l'état cardiovasculaire en cas de cardiopathie connue ou par un dépis-tage lorsque la cardiopathie n'est pas connue. Les différentes séries européennes ou américaines permettent d'identifier les causes les plus fréquentes même si la comparaison des informations est souvent difficile car les sources de données sont différentes de même que les classes d'âge étudiées [3][4][5]. L'incidence de la mort subite à l'effort des sujets jeunes varie selon les pays et les séries entre 0,4 et 3,6 pour 100 000 personnes-années.…”

Section: Paradoxe Du Sportunclassified

Sport et cardiopathies congénitales chez l’enfant

2017

View full text Add to dashboard Cite

“…A German national study found that heart failure and sudden cardiac deaths accounted for 23% and 29% of all deaths, respectively, between 2001 and 2008, whereas corresponding proportions shifted to 30% and 20% between 2009 and 2015 16. These statistics may reflect successes in risk stratification and prevention, in combination with an increased prevalence and severity of heart failure in ageing survivors.…”

Section: Risk Stratification For Sudden Cardiac Deathmentioning

confidence: 99%

“…While the overall incidence of sudden death in adults with CHD at large is relatively low (<0.1% per year), a handful of CHD lesions account for the majority of cases, namely tetralogy of Fallot, complete transposition of the great arteries (TGA) with an atrial baffle (ie, Mustard or Senning), congenitally corrected TGA, left ventricular outflow obstruction (ie, aortic stenosis and aortic coarctation) and Eisenmenger syndrome. In contrast, heart failure is the leading cause of mortality in Ebstein anomaly and univentricular hearts 16 17…”

Section: Risk Stratification For Sudden Cardiac Deathmentioning

confidence: 99%

Ventricular arrhythmias and sudden cardiac death in adults with congenital heart disease

Khairy

2016

Heart

View full text Add to dashboard Cite

Remarkable gains in survival have led to an unprecedented number of adults with congenital heart disease. Arrhythmias collectively comprise the most common complication encountered. Recognising the unique issues and challenges involved in managing arrhythmias in adults with congenital heart disease and the consequential decisions surrounding sudden death prevention, expert societies have proposed evidence-based recommendations. On the whole, acute ventricular arrhythmias are managed according to general cardiology guidelines, while taking into consideration congenital heart disease-specific issues, such as positioning of patches or paddles according to location of the heart. Implantable cardioverter-defibrillators (ICDs) are indicated for secondary prevention in patients with sustained ventricular tachycardia or resuscitated cardiac arrest in the absence of a reversible cause. Pharmacological therapy and catheter ablation can be effective in reducing recurrent ICD shocks. Risk-benefit assessment for primary prevention ICDs is a major challenge. Although a clearer picture has emerged of the high-risk patient with tetralogy of Fallot, ICD indications for those with systemic right ventricles or univentricular hearts remain contentious. Challenges to ICD implantation include obstructed veins, conduits and baffles, atrioventricular valve disease and intracardiac shunts. In selected patients, customised systems with epicardial and/or subcutaneous coils may represent a viable solution. Alternatively, the subcutaneous ICD is an attractive option for patients in whom transvenous access is not feasible or desirable and in whom bradycardia and antitachycardia pacing features are not essential. Continued advances in risk stratification and device technologies carry the potential to further improve efficacy and safety outcomes in this growing population of patients.

show abstract

Cause of death in adults with congenital heart disease — An analysis of the German National Register for Congenital Heart Defects

Cited by 161 publications

References 19 publications

Diagnosis and Management of Noncardiac Complications in Adults With Congenital Heart Disease: A Scientific Statement From the American Heart Association

Diagnosis and Management of Noncardiac Complications in Adults With Congenital Heart Disease: A Scientific Statement From the American Heart Association

Sport et cardiopathies congénitales chez l’enfant

Ventricular arrhythmias and sudden cardiac death in adults with congenital heart disease

Contact Info

Product

Resources

About