Causes and Consequences of Systemic Venous Hypertension

Paulus, B. M.; Ali, Sheharyar; Zia, Ayhan A.; Davis, Richard C.; Weber, Karl T.; Ahmad, Mahmood; Mansbach, Charles M.; Smith, W. Chapman

doi:10.1097/maj.0b013e318176abe9

Cited by 10 publications

(6 citation statements)

References 58 publications

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“…The presence of most chronic conditions did not influence the subsequent development of lymphedema. While it was speculated that conditions such as high blood pressure and diabetes may exacerbate a damaged lymphatic system due to increased hydrostatic pressure [35], we did not find such an association in this study. Medications taken to control high blood pressure [14], may have negated the effect of increased hydrostatic pressure.…”

Section: Discussioncontrasting

confidence: 95%

Lymphedema following breast cancer: The importance of surgical methods and obesity

Tsai¹,

Dennis²,

Lynch³

et al. 2018

Front Womens Healt

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Background: Breast cancer-related arm lymphedema is a serious complication that can adversely affect quality of life. Identifying risk factors that contribute to the development of lymphedema is vital for identifying avenues for prevention. The aim of this study was to examine the association between the development of arm lymphedema and both treatment and personal (e.g., obesity) risk factors. Methods: Women diagnosed with breast cancer in Iowa during 2004 and followed through 2010, who met eligibility criteria, were asked to complete a short computer assisted telephone interview about chronic conditions, arm activities, demographics, and lymphedema status. Lymphedema was characterized by a reported physician-diagnosis, a difference between arms in the circumference (> 2cm), or the presence of multiple self-reported arm symptoms (at least two of five major arm symptoms, and at least four total arm symptoms). Relative risks (RR) were estimated using logistic regression. Results: Arm lymphedema was identified in 102 of 522 participants (19.5%). Participants treated by both axillary dissection and radiation therapy were more likely to have arm lymphedema than treated by either alone. Women with advanced cancer stage, positive nodes, and larger tumors along with a body mass index > 40 were also more likely to develop lymphedema. Arm activity level was not associated with lymphedema. Conclusions: Surgical methods, cancer characteristics and obesity were found to contribute to the development of arm lymphedema. Vigorous arm activity post-surgery was not found to increase the risk of arm lymphedema.

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Section: Discussioncontrasting

confidence: 95%

Lymphedema following breast cancer: The importance of surgical methods and obesity

Tsai¹,

Dennis²,

Lynch³

et al. 2018

Front Womens Healt

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“…The rate of release of CK is related to the velocity of the lymph [5]. Hypertension is associated with increased filtration and formation of interstitial fluid, resulting in a greater lymph flow rate [6,7]. Thus we speculate that the hypertensive subject experienced an increased lymph flow rate, which led to a more rapid accumulation of CK in the bloodstream.…”

Section: Discussionmentioning

confidence: 89%

Is hypertension associated with a greater increase in creatine kinase activity following cycling exercise? A case study

Henriques

Tebaldi

Coelho

et al. 2018

Arterial Hypertension

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We describe discrepant behavior of serum creatine kinase (CK) activity during and after cycling in a hypertensive athlete when compared to the healthy athletes from the same team of endurance cyclists. Heart Rate (HR), Blood Pressure (BP), Perceived Exertion (PE) and serum CK activity were evaluated before, during and after 150 km indoor cycling. The results showed that there were no differences between the hypertensive athlete and the healthy athletes in time trial (186.3 min vs. 179.1 ± 14.9 min), HR (159.3 ± 11.4 bpm vs. 169.5 ± 7.8 bpm respectively) and PE (6.3 ± 1.5 vs. 6.3 ± 1.3). Systolic BP was higher in hypertensive athlete before, during and after the exercise. Serum CK activity was higher (+47%) at baseline and exhibited a higher increase (> +200%) after exercise. Our finding shed light on a hypothesis regarding the interindividual variability of serum CK activity and its possible interaction with hypertension.

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“…Diastolic dysfunction is predominant in preeclampsia irrespective of gestation at onset and predisposes to reduced venous return and venous congestion. Reflex venoconstriction occurs to support venous return, resulting in systemic venous hypertension and increased central venous pressure (Paulus et al 2008). Localised renal vein congestion leads to reduced kidney perfusion with subsequent renal dysfunction -the severity of which depends on the level of preserved arterial blood flow (Mullens et al 2009).…”

Section: Venous Congestionmentioning

confidence: 99%

Preeclampsia: a gestational cardiorenal syndrome

Gyselaers

Thilaganathan

2019

The Journal of Physiology

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It is generally accepted today that there are two different types of preeclampsia: an early‐onset or placental type and a late‐onset or maternal type. In the latent phase, the first one presents with a low output/high resistance circulation eventually leading in the late second or early third trimester to an intense and acutely aggravating systemic disorder with an important impact on maternal and neonatal mortality and morbidity; the other type presents initially as a high volume/low resistance circulation, gradually evolving to a state of circulatory decompensation usually in the later stages of pregnancy, with a less severe impact on maternal and neonatal outcome. For both processes, numerous dysfunctions of the heart, kidneys, arteries, veins and interconnecting systems are reported, most of them presenting earlier and more severely in early‐ than in late‐onset preeclampsia; however, some very specific dysfunctions exist for either type. Experimental, clinical and epidemiological observations before, during and after pregnancy are consistent with gestation‐induced worsening of subclinical pre‐existing chronic cardiovascular dysfunction in early‐onset preeclampsia, and thus sharing the pathophysiology of cardiorenal syndrome type II, and with acute volume overload decompensation of the maternal circulation in late‐onset preeclampsia, thus sharing the pathophysiology of cardiorenal syndrome type 1. Cardiorenal syndrome type V is consistent with the process of preeclampsia superimposed upon clinical cardiovascular and/or renal disease, alone or as part of a systemic disorder. This review focuses on the specific differences in haemodynamic dysfunctions between the two types of preeclampsia, with special emphasis on the interorgan interactions between heart and kidneys, introducing the theoretical concept that the pathophysiological processes of preeclampsia can be regarded as the gestational manifestations of cardiorenal syndromes.

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Causes and Consequences of Systemic Venous Hypertension

Cited by 10 publications

References 58 publications

Lymphedema following breast cancer: The importance of surgical methods and obesity

Lymphedema following breast cancer: The importance of surgical methods and obesity

Is hypertension associated with a greater increase in creatine kinase activity following cycling exercise? A case study

Preeclampsia: a gestational cardiorenal syndrome

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