Causes and Factors of Male Infertility

Kolesnikova, L. I.; Колесников, С. И.; Курашова, Н. А.; Bairova, T. A.

doi:10.15690/vramn.v70.i5.1445

Cited by 27 publications

(16 citation statements)

References 16 publications

(30 reference statements)

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“…Recent epidemiological data has shown that approximately 15% of married/unmarried couples are affected by infertility for which only 40-50% cases are attributable to male infertility [26] which itself could be due to either azoospermia or erectile dysfunction [27]. Identifiable factors (reversible/irreversible) influencing male fertility as reported by previous studies include drugs (such as anabolic steroid, replacement testosterone, and opiates), testicular varicocele, undescended testes, urinary tract infections, testicular tumor, hormonal imbalances, premature or retrograde ejaculation, prolonged heat exposure, obesity, older age, cigarette smoking, alcohol, heavy metals, pesticides, oxidative stress, genetic factors, and different environmental and nutritional factors [28–34]. Thus, in managing male infertility, treatment plans are designed alongside the identifiable possible cause and these interventions could be either medical or surgical [27, 35].…”

Section: Discussionmentioning

confidence: 99%

Evaluation of Male Fertility-Enhancing Activities of Water Seed Extract of Hunteria umbellata in Wistar Rats

Adeneye

Olagunju

Murtala

2019

Evidence-Based Complementary and Alternative Medicine

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Background. In this study, the male fertility-enhancing activity of 100, 200, and 400 mg/kg/day of Hunteria umbellata water seed extract (HU) in Wistar rats was studied for 60 days. In doing this, effect of repeated doses of HU was studied on the weight gain pattern, gonadosomatic index (GSI), serum follicle stimulating hormone (FSH), luteinizing hormone (LH), testosterone (TS), prolactin (PRL), and estradiol (ES)} as well as testicular antioxidant status of the treated rats as a way of elucidating the mechanism(s) of action of HU. Method. Thirty-six (36) male Wistar rats were randomly divided into six groups (I-VI) of six rats per group. Group I rats were gavaged with 10 ml/kg/day of distilled water and served as an untreated control; Group II rats were gavaged with 0.3 mg/kg/day of clomiphene in distilled water; Groups III-V rats received 100 mg/kg/day, 200 mg/kg/day, and 400 mg/kg/day of HU, respectively, and Group VI rats received 20 mg/kg/day of Vitamin C all in distilled water. All treatments were for 60 days after which the treated rats were humanely sacrificed. Sera of blood samples were processed for the above stated hormonal profile. Similarly, testicular tissues obtained were processed for semen analysis and complete antioxidant profile of the HU-treated testicles by assaying for superoxide dismutase (SOD), catalase (CAT), and glutathione (GSH), glutathione reductase (GSR), glutathione peroxidase (GSH-Px), and Thiobarbituric Reactive Species (TBARS). Results. Prolonged treatments with 100 mg/kg/day, 200 mg/kg/day, and 400 mg/kg/day of HU for 60 days induced dose dependent reductions in weight gain pattern with the most significant (p<0.001) effect recorded with the highest dose of HU. Conversely, significant (p<0.001) increase was recorded for GSI at the same HU dose. Clomiphene and HU also induced significant (p<0.01, p<0.001) dose dependent increases in the total sperm count, %live sperm, but reverse effects on %dead sperm and %abnormal sperm. On the hormonal profile, oral treatment with 100 mg/kg/day, 200 mg/kg/day, and 400 mg/kg/day of the extract induced profound (p<0.05, p<0.01, and p<0.001) dose related increases in the sera TS, LH, and FSH while it caused reverse effect on serum PRL but caused no significant alterations in the serum ES levels. Similarly, oral treatment with vitamin C and 100-400 mg/kg/day of HU induced profound (p<0.05, p<0.01, and p<0.001) increases in the antioxidant enzyme activities. Conclusion. Overall, prolonged oral treatment with 100-400 mg/kg body weight of HU for 60 days significantly improved sperm function which was mediated via enhanced spermatogenesis, steroidogenesis, and antioxidant mechanisms.

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Section: Discussionmentioning

confidence: 99%

Evaluation of Male Fertility-Enhancing Activities of Water Seed Extract of Hunteria umbellata in Wistar Rats

Adeneye

Olagunju

Murtala

2019

Evidence-Based Complementary and Alternative Medicine

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“…About 20–30% of infertility is caused by male factors [ 31 ]. The sex chromosomes (X and Y) in men play key roles in germ cell development.…”

Section: Discussionmentioning

confidence: 99%

A novel TEX11 mutation induces azoospermia: a case report of infertile brothers and literature review

Sha

Zheng

et al. 2018

BMC Med Genet

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BackgroundTestis-expressed gene 11 (TEX11) is an X-linked gene and essential for meiotic recombination and chromosomal synapsis. TEX11 deficiency causes meiotic arrest and male infertility, and many TEX11 mutations have been found in azoospermic and infertile men.Case presentationThis study reported one novel TEX11 mutation (2653G → T, in exon 29, GenBank accession number, NM_031276) in two brothers with azoospermia. This mutation was firstly screened out by whole-exome sequencing (WES) and further verified by amplifying and sequencing the specific exon 29. Surprisingly, the same exonic missense mutation (W856C) was observed in two brothers but not in their mother. Histological analysis of testicular biopsy from both brothers revealed meiotic arrest and no post-meiotic round spermatids and mature spermatozoa were observed in the seminiferous tubules. TEX11 expression was observed strongly in spermatogonia and weakly in spermatocytes, but not in Sertoli cells and interstitial cells.ConclusionsWe identified one novel TEX11 mutation in two brothers and summarized the literature regarding TEX11 mutations and male infertility. This study and previous literature indicate that TEX11 mutations are closely associated with male infertility, especially azoospermia, although auxiliary clinical analyses are needed to figure out the causes of male infertility.

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“…It affects 10-15% of couples in reproductive age (Winters & Walsh, 2014). Some studies show that environmental, physiological and genetic factors are related to 25% of male factor infertility due to semen quality, including oxidative stress, which has frequently been associated with the problem (Kolesnikova et al, 2015;Aitken, 2016).…”

Section: Introductionmentioning

confidence: 99%

Unbalance of Se and nutritional status in male infertility

Cunha

Teixeira

Daltro

et al. 2021

JBRA Assisted Reproduction

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Objective: To evaluate the selenium status and oxidative stress in male infertility cases selected from a private human reproduction center in the state of Ceará, Brazil. Methods: The present study had a cross-sectional quantitative approach, carried out between January and October 2013 at a Human Reproduction Center. The studied population was composed of 49 male individuals seen at the clinic, aged between 18 and 60 years. Blood samples were collected to measure serum selenium concentrations, erythrocyte activity and glutathione peroxidase. After medical diagnosis, the participants were divided into fertile and infertile groups. Blood samples were collected for establishing Se concentrations in plasma and erythrocytes, and measurements of the enzymatic activity of glutathione peroxidase in the erythrocytes. Result: it resulted in 53.1% of fertile men and 46.9% of infertile men. The average age of the fertile group was 34.1 years and the infertile group was 37.3 years. Regarding the assessment of nutritional status, the scatter diagram of the infertility group showed a higher body mass index and waist circumference, showing that this group has a higher risk of global and abdominal obesity compared to the fertile group ( p <0.0001, respectively). There were similarities between the groups regarding caloric intake, macronutrient and selenium intake. Conclusion: We can conclude that the serum values of selenium, in excess and in deficiency, can be harmful to male fertility.

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Causes and Factors of Male Infertility

Cited by 27 publications

References 16 publications

Evaluation of Male Fertility-Enhancing Activities of Water Seed Extract of Hunteria umbellata in Wistar Rats

Evaluation of Male Fertility-Enhancing Activities of Water Seed Extract of Hunteria umbellata in Wistar Rats

A novel TEX11 mutation induces azoospermia: a case report of infertile brothers and literature review

Unbalance of Se and nutritional status in male infertility

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