Causes and Management of Wound Infection

Kashha, Ahmad Mohammad; Zailai, Ayat Hassan; Alsaadi, Waad Suliman; Almutawa, Rahaf Yaseen; Albarakati, Moath Hassan; Almhmadi, Amir Hamoud; Alkhuzaie, Wafa Saleh; AlZahrani, Abdullah H; balbaid, Shahad Khalid Ali

doi:10.12816/0039686

Cited by 2 publications

(1 citation statement)

References 11 publications

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“…Wound infection was defined as swelling with a focal rise in temperature and fever. [ 23 ] Necrosis was defined as appearance of the necrotic tissue on the wound bed after treatment. [ 24 ] Hospitalized patients were directly evaluated on the 7th day, and after being discharged, they were subsequently evaluated in the outpatient clinic at the Department of Plastic Surgery.…”

Section: Methodsmentioning

confidence: 99%

Negative pressure wound therapy for skin necrosis prevention after snakebite in the emergency department

et al. 2021

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This retrospective cohort study aimed to compare the effectiveness of conventional treatment and ultra-early application of negative pressure wound therapy (NPWT) in patients with snakebites. Patients who visited the emergency department within 24 hours after a snakebite were assigned to the non- NPWT or NPWT group. Swelling resolution time and rates of necrosis, infection, and operations were compared between the 2 groups. The Stony Brook Scar Evaluation Scale was used to measure short- and long-term wound healing results. Among the included 61 patients, the swelling resolution time was significantly shorter in the NPWT group than in non- NPWT group (P = .010). The NPWT group showed lower necrosis (4.3% versus 36.8%; P = .003) and infection (13.2% and 4.3%; P = .258) rates than the non- NPWT group. The median Stony Brook Scar Evaluation Scale scores were higher in the NPWT group than in the non- NPWT group (P< .001). These findings suggest that ultra-early application of NPWT reduces edema, promotes wound healing, and prevents necrosis in patients with snakebites.

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Section: Methodsmentioning

confidence: 99%

Negative pressure wound therapy for skin necrosis prevention after snakebite in the emergency department

et al. 2021

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Preparation of Novel Marine Enterococcus faecium MSD8 Exopolysaccharide Ointment and In Vivo Evaluation of Its Impact on Cutaneous Wound Healing in Male Albino Rats

Abdel-monem,

Sabry,

Ghozlan

et al. 2024

Probiotics & Antimicro. Prot.

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The current study describes the isolation of exopolysaccharide (EPS) producing lactic acid bacteria (LAB) from marine samples and testing different sugar additives with different proportions for enhanced EPS yield. The isolate MSD8 showed the most potential, yielding 200 mg/L of EPS after being cultivated at 37 °C for 48 h on de Man Rogosa and Sharpe medium (MRS) supplemented with 3% sucrose. The marine isolate MSD8 was identified as Enterococcus faecium with 99.58% probability using 16S rRNA gene sequencing. The obtained sequence was deposited in GenBank and assigned the accession number MW924065. The feature of MSD8-EPS was characterized by estimating the total carbohydrate content by UV–vis to be ~ 71%. The FTIR analysis further indicated the presence of characteristic bands of polysaccharide. The cytotoxicity of the produced MSD8-EPS was assessed using human skin fibroblasts (HSF). The IC50 was determined to be > 100 μg/mL, which signifies that MSD8-EPS is safe for skin application. The produced EPS was used to prepare a novel ointment, which was tested for wound healing ability in male albino rats. The ointment significantly (P ≤ 0.05) shortened the time needed for wound healing, as it successfully healed the wounds by 94.93% on the 7th day and completely (100%) healed the wound by the 12th day. In comparison, the control group was healed by 73.2% and 84.83%, respectively. The data confirm that the prepared ointment can safely be used for pharmaceutical wound care products.

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Causes and Management of Wound Infection

Cited by 2 publications

References 11 publications

Negative pressure wound therapy for skin necrosis prevention after snakebite in the emergency department

Negative pressure wound therapy for skin necrosis prevention after snakebite in the emergency department

Preparation of Novel Marine Enterococcus faecium MSD8 Exopolysaccharide Ointment and In Vivo Evaluation of Its Impact on Cutaneous Wound Healing in Male Albino Rats

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