Causes of autonomic dysfunction in idiopathic recurrent kidney stone formers

Domingos, Fernando; Escalda, A.

doi:10.1007/s11255-011-9983-0

Cited by 3 publications

(2 citation statements)

References 37 publications

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“…What is interesting is that the recent study of Domingos and Escalda 15 revealed autonomic dysfunction even in recurrent kidney stone formers what contributed with higher HR and BP comparing to healthy controls. One of the important determinants of SNS hyperactivity is abnormal renal sodium excretion and activation of the renin-angiotensin-aldosterone system and then volume overloud, which per se may also play a role.…”

Section: Discussionmentioning

confidence: 93%

Circulating Levels of Renalase, Norepinephrine, and Dopamine in Dialysis Patients

et al. 2013

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Background: hRenalase may degrade catecholamines and regulate sympathetic tone and blood pressure (BP). The aim of the study was to assess dopamine (DA), norepinephrine (NE), and renalase in 75 hemodialysis (HD) and 26 peritoneal dialysis (PD) patients and their correlations with heart rate (HR), BP, a type of hypotensive therapy, and residual renal function. Methods: Renalase, DA, NE were studied using commercially available assays. Results: Renalase and NE were higher and DA was lower in dialyzed groups comparing to healthy volunteers. Hemodialysis patients had lower NE and higher renalase level. Norepinephrine was higher in anuric patients in HD group. Renalase correlated with dialysis vintage and inversely with residual diuresis. Dopamine correlated with residual diuresis in the whole study cohort, with HR in PD patients, with renalase in HD patients. Norepinephrine correlated with aortic diameter in PD patients. Norepinephrine was significantly higher in patients with coronary artery disease (CAD) in HD group. Hemodialysis population with CAD had lower NE and higher DA and renalase level than their PD counterparts. In the follow up, 27% of HD group died. Cardiac death was diagnosed in 17% and there was higher renalase level than in noncardiac death. Conclusions: Elevated level of circulating renalase in dialysis patients is rather related to kidney function and the sympathetic nervous system hyperactivity found in this population. The real excess of renalase in the pathogenesis of cardiovascular disorders in patients with chronic kidney disease still remains to be proven. If confirmed, it may give a new way for pathophysiological therapy.

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Section: Discussionmentioning

confidence: 93%

Circulating Levels of Renalase, Norepinephrine, and Dopamine in Dialysis Patients

et al. 2013

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“…CKD as well as older age is characterized by elevated sympathetic nerves system activity, which correlates with increased vascular resistance and systemic BP and leads to CVD. Sympathetic nerves system overactivity in renal patients also aggravates kidney failure progression 4–6…”

Section: Introductionmentioning

confidence: 99%

Age influence on renalase and catecholamines concentration in hypertensive patients, including maintained dialysis

Zbroch¹,

Musiałowska²,

Koc-Żórawska³

et al. 2016

CIA

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BackgroundHypertension in elderly patients is one of the main problems in cardiovascular diseases. The sympathetic nervous system hyperactivity seen in older patients is a known risk factor for hypertension and other cardiovascular events as well as chronic kidney disease. Renalase, secreted by the kidney and circulated in blood, may regulate the sympathetic tone by catecholamine degradation and in this way has an impact on cardiovascular and renal complications.ObjectiveTo assess the impact of age on renalase and catecholamine concentration in hypertensive patients, including those on dialyses and its possible relation to blood pressure control and cardiovascular disease.MethodsThe study cohort of 211 patients was divided into two groups according to age below 65 years (range 19–64) and above 65 years (range 65–86). The older group represented 38% of the whole studied population and 75% of them were dialyzed. The two groups of different ages were also divided into dialysis and nondialysis subgroups. The serum renalase, dopamine, and norepinephrine concentration together with blood pressure value and echocardiography were assessed.ResultsPatients aged 65 years and more had higher renalase (20.59 vs 13.14 µg/mL, P=0.02) and dopamine (41.71 vs 15.46 pg/mL, P<0.001) concentration as well as lower diastolic blood pressure (75.33 vs 85 mmHg, P=0.001), advanced abnormalities in echocardiography, and more often suffered from diabetes and coronary artery disease. The significant correlation between age and renalase (r=0.16; P=0.019), norepinephrine (r=0.179; P=0.013), and dopamine (r=0.21; P=0.003) was found in the whole study population. In the nondialysis subgroup, 44% had chronic kidney disease, mostly in the stage 2 (83%). There was a significantly higher norepinephrine concentration (1.21 vs 0.87 ng/mL; P=0.008) in older patients of that population. In the dialysis subgroup, there were no differences between renalase and catecholamine level but older participants had lower diastolic blood pressure (69 vs 78 mmHg, P=0.001) and ejection fraction (51% vs 56.8%, P=0.03).ConclusionThe elevated renalase level in older hypertensive patients is related rather to kidney function and cardiovascular diseases than to age itself. Thus, renalase appears to be the possible new marker of these indications in this special population.

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Calculus Renal Disease

Losito

2018

Updates in Hypertension and Cardiovascular Protection

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Causes of autonomic dysfunction in idiopathic recurrent kidney stone formers

Abstract: Several factors may contribute to the presence of autonomic dysfunction in patients with recurrent nephrolithiasis. This abnormality has significant implications in cardiovascular risk assessment and treatment planning.

Cited by 3 publications

References 37 publications

Circulating Levels of Renalase, Norepinephrine, and Dopamine in Dialysis Patients

Circulating Levels of Renalase, Norepinephrine, and Dopamine in Dialysis Patients

Age influence on renalase and catecholamines concentration in hypertensive patients, including maintained dialysis

Calculus Renal Disease

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