Causes of changes in carotid intima-media thickness: a literature review

Qu, Baoge; Qu, Tao

doi:10.1186/s12947-015-0041-4

Cited by 76 publications

(67 citation statements)

References 139 publications

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“…A correlation between older age and higher cIMT/cEMT in the patient group is an expected result because age is a ‘traditional’ cardiovascular risk factor (Qu and Qu, ). The absence of a correlation between cIMT/cEMT and age in the control group seems remarkable.…”

Section: Discussionmentioning

confidence: 91%

“…This is an interesting result because peripheral insulin resistance was explained as an outcome of endothelial dysfunction in Behc ßet's disease (Erdem et al, 2006). A correlation between older age and higher cIMT/ cEMT in the patient group is an expected result because age is a 'traditional' cardiovascular risk factor (Qu and Qu, 2015). The absence of a correlation between cIMT/ cEMT and age in the control group seems remarkable.…”

Section: Oral Diseasesmentioning

confidence: 84%

See 1 more Smart Citation

Subclinical atherosclerosis in patients with recurrent aphthous stomatitis

Şereflican

Dağıstan

et al. 2016

Oral Diseases

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Section: Discussionmentioning

confidence: 91%

Section: Oral Diseasesmentioning

confidence: 84%

Subclinical atherosclerosis in patients with recurrent aphthous stomatitis

Şereflican

Dağıstan

et al. 2016

Oral Diseases

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“…For the last two decades various methods have been in use such are flow-mediated endothelium-dependent vasodilation (FMD), and intima-media thickness assessment (IMT), while venous plethysmography, and impulse wave analysis are less dependable. Magnetic resonance is mainly used for arterial compliance and large blood vessels analysis (25)(26)(27)(28)(29)(30)(31)(32)(33).…”

Section: Methods For Evaluation Of Peripheral Artery Disease Pathophymentioning

confidence: 99%

Significance of the pulsatility index in the evaluation of hemodynamic changes in peripheral arterial circulation in the obese treated with orlistat

et al. 2020

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Background/Aim. Prolonged hyperinsulinemia accelerates the process of endothelial dysfunction and arteriosclerotic changes affecting the development of cardiovascular and cerebrovascular diseases. There are various measuring techniques for the evaluation of early functional changes in the arterial wall such are flow-mediated endothelium-dependent vasodilation, impulse wave analysis, intima-media thickness assessment, venous plethysmography and so on, however, each having certain limitations in results interpretation. The aim of this study was to indicate the correlation of pulsatility index that shows peripheral arterial contractility with the changes in metabolic parameters under the conditions of insulin resistance. Methods. The study included a total of 30 healthy obese subjects with the values of body mass index more than 30 kg/m 2 randomized with double blind design into two groups: placebo and orlistat. The extent of insulin sensitivity was calculated on the basis of the values of glycemia and insulinemia using the formula. Results. The obtained results suggest a statistically significant improvement in the pulsatility index in the group orlistat (p < 0.002), while there was no such improvement in the placebo group. Conclusion. The results obtained in this study indicate the improvement in insulin sensitivity within early arteriosclerosis as a significantly favorable factor for peripheral arterial circulation additionally supported by the reduction in the level of lipid fractions, especially triglycerides. Early hemodynamic changes under the conditions of the reduced insulin resistance are characterized by the increase in arterial wall contractility evaluated with pulsatility index determination. Apstrakt.Uvod/Cilj. Dugotrajna hiperinsulinemija ubrzava proces endotelne disfunkcije i nastajanja arteriosklerotskih promena što utiče na nastanak kardiovaskularnih i cerebrovaskularnih oboljenja. Za procenu ranih funkcinalnih promena u arterijskom zidu danas postoje različite metode merenja kao što su protokom posredovana endotel zavisna vazodilatacija-FMD (flow mediated vasodilatation), analiza pulsnog talasa, procena debljine intime i medije (FMD), venska pletizmografija...svaka sa određenim ograničenjima u tumačenju rezultata. Cilj našeg rada je bio da ukazemo na povezanost pulzatilnog indeksa (PI)-koji pokazuje kontraktilnost perifernih arerija, sa izmenjenim metaboličkim parametrima u uslovima insulinske rezistencije. Metode. Ispitivanjem je bilo obuhvaćeno 30 zdravih gojaznih osoba, sa vrednostima BMI iznad 3o kg/m 2 , koji su po metodi duplo slepog dizajna bili randomizovani u dve grupe-placebo i orlistat. Na osnovu vrednosti glikemija i insulinemija, primenom formule bio je izračunat nivo insulinske senzitivnosti (ISI). Rezultati. Naši rezultati pokazuju da je, u orlistat (p<0,002) grupi, došlo do statistički značajnog poboljšanja PI, dok u placebo grupi nije bilo signifikantnog uvećanja PI. Zaključak. Dobijeni rezultati ukazuju, da je poboljšanje insulinske senzitivnosti, u fazi rane ateroskleroze, znača...

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“…Covariates of interest were chosen based on prior literature on potential factors that influence alcohol consumption and changes in early atherosclerosis development (Qu and Qu, ). Age was assessed in years, using participants’ self‐reported date of birth.…”

Section: Methodsmentioning

confidence: 99%

The Impact of Past and Current Alcohol Consumption Patterns on Progression of Carotid Intima‐Media Thickness Among Women and Men Living with HIV Infection

Chichetto

Plankey

Abraham³

et al. 2019

Alcoholism Clin & Exp Res

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Background: The relationship between alcohol consumption and atherosclerosis has not been sufficiently examined among people living with HIV (PLWH).Methods: We analyzed data from PLWH in the Women's Interagency HIV Study (WIHS; n = 1,164) and the Multicenter AIDS Cohort Study (MACS; n = 387) with no history of cardiovascular disease (CVD). Repeated measures of intima-media thickness of the right common carotid artery (CCA-IMT) were assessed using B-mode ultrasound from 2004 to 2013. Current alcohol consumption was collected at time of CCA-IMT measurement and was categorized according to gender-specific weekly limits. Group-based trajectory models categorized participants into past 10-year consumption patterns (1994 to 2004). Multivariate generalized estimating equations were conducted to assess the association of past and current alcohol use patterns on change in CCA-IMT by cohort, controlling for age, race, cigarette and illicit drug use, probable depression, HIV RNA viral load, antiretroviral therapy exposure, and hepatitis C coinfection.Results: Among the WIHS, past heavy alcohol consumption was associated with increased CCA-IMT level over time (b = 8.08, CI 0.35, 15.8, p = 0.04), compared to abstinence. Among the MACS, compared to abstinence, all past consumption patterns were associated with increased CCA-IMT over time (past low: b = 15.3, 95% CI 6.46, 24.2, p < 0.001; past moderate: b = 14.3, CI 1.36, 27.2, p = 0.03; past heavy: b = 21.8, CI 4.63, 38.9, p = 0.01). Current heavy consumption was associated with decreased CCA-IMT among the WIHS (b = À11.4, 95% CI À20.2, À2.63, p = 0.01) and MACS (b = À15.4, 95% CI À30.7, À0.13, p = 0.04). No statistically significant time by consumption pattern effects were found.Conclusions: In both cohorts, 10-year heavy consumption was associated with statistically significant increases in carotid artery thickness, compared to abstinence. Long-term patterns of drinking at any level above abstinence were particularly significant for increases in IMT among men, with heavy consumption presenting with the greatest increase. Our results suggest a potentially different window of risk among past and current heavy drinkers. Further studies are needed to determine whether alcohol consumption level is associated with intermediate measures of atherosclerosis. Alcohol screening and interventions to reduce heavy consumption may benefit PLWH who are at risk of CVD.

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Causes of changes in carotid intima-media thickness: a literature review

Cited by 76 publications

References 139 publications

Subclinical atherosclerosis in patients with recurrent aphthous stomatitis

Subclinical atherosclerosis in patients with recurrent aphthous stomatitis

Significance of the pulsatility index in the evaluation of hemodynamic changes in peripheral arterial circulation in the obese treated with orlistat

The Impact of Past and Current Alcohol Consumption Patterns on Progression of Carotid Intima‐Media Thickness Among Women and Men Living with HIV Infection

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