Causes of cholestasis in Thailand

Juttijudata, P; Chiemchalsri, Cherdchai; Palavatana, C; Churnratanakul, S

doi:10.1016/0002-9610(84)90167-3

Cited by 15 publications

(1 citation statement)

References 34 publications

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“…Cholangiocarcinoma, especially the hilar cholangiocarcinoma, is a common cause of malignant biliary obstruction in Southeast Asia. [ 1 ] Due to nonspecific early symptoms, the great a majority of patients are detected at an advanced stage of the disease. Therefore, the prognosis of cholangiocarcinoma is very poor and less than 20% of patients are suitable for curative resection.…”

Section: Introductionmentioning

confidence: 99%

The efficacy of temporary placement of nasobiliary drainage following endoscopic metal stenting to prevent post-ERCP cholangitis in patients with cholangiocarcinoma

Wan

Sumin

Zhao

et al. 2018

Saudi J Gastroenterol

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Background/Aims:Although endoscopic metal biliary endoprosthesis (EMBE) is widely accepted as the most suitable drainage method for patients with unresectable malignant obstruction, uncontrolled post-procedural cholangitis is still a problem. We aimed to validate a new treatment modality to prevent post-ERCP cholangitis in patients with unresectable cholangiocarcinoma.Patients and Methods:A total of 378 patients who were diagnosed with unresectable malignant biliary obstruction and underwent EMBE or temporary endoscopic nasobiliary drainage (ENBD) following EMBE placement, from January 2010 to July 2016, were enrolled in this retrospective study. Incidence of cholangitis, related infectious indicators, success rate of biliary drainage, and occurrence of complications were evaluated.Results:The risk of overall cholangitis and related infectious indicators was significantly lower in EMBE plus ENBD group than that in EMBE group. The occurrence of cholangitis was 2.4% versus 11.9% (P = 0.004). On further analysis of subgroups, although no difference was detected in nonhilar cholangiocarcinoma subgroup, the incidence of cholangitis and related infectious indicators in hilar cholangiocarcinoma subgroup with EMBE modality were distinctly higher than that with EMBE plus ENBD modality (type I + II was 18.5% vs 0%, P < 0.05; type III + IV was 19.8% vs 3.8%, P < 0.05). No significant difference was found in successful biliary drainage rate and procedure-related complications when all subgroups were compared.Conclusions:The temporary placement of ENBD following EMBE is a simple and effective treatment modality to prevent post-ERCP cholangitis, especially in patients with hilar cholangiocarcinoma.

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Section: Introductionmentioning

confidence: 99%