Causes of chronic kidney disease in Egyptian children

Safouh, Hesham; Fadel, Fatina; Essam, Rascha G.; Salah, Ahmed; Bekhet, Abdallah

doi:10.4103/1319-2442.160224

Cited by 24 publications

(17 citation statements)

References 2 publications

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“…Children with CKD face a lifelong increase in morbidity and mortality, as well as a poor QOL 1 . In the absence of a national registry, the exact incidence of CKD in children in Egypt is not known; however, a relatively recent study from 11 university hospitals reported 1018 Egyptian children suffering from various stages of CKD, signifying the burden of this illness 2 …”

Section: Introductionmentioning

confidence: 99%

Pediatric kidney transplantation in Egypt: Results of 10‐year single‐center experience

Fadel

Bazaraa

Badawy

et al. 2020

Pediatric Transplantation

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Pediatric kidney transplantation is a multidisciplinary therapy that needs special consideration and experience. In this study, we aimed to present CUCH experience; over a 10‐year period, as a specialized center of kidney transplantation in children. We studied 148 transplantations performed at a single center from 2009 to 2018. Pretransplant and follow‐up data were collected and graft/patient survival rates were evaluated. A total of 48 patients developed at least one rejection episode during 688 patient‐years of follow‐up. Infections, recurrence of original disease, and malignancy were the most important encountered medical complications (20%, 2%, and 1.4%, respectively). One‐year patient survival was 94.1%, while graft and patient survival was 91.9%. Graft/patient survival at 5, 7, and 9 years was 90%, 77%, and 58%, respectively. Infections were the main cause (69%) of mortality. Death with a functioning graft and CR were the main causes of graft loss (48% and 33%, respectively). Pediatric kidney transplantation in Egypt is still a challenging yet successful experience. Rejections and infections are the most frequent complications. Short‐term outcomes surpass long‐term ones and graft survival rates are similar to the international standard.

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Section: Introductionmentioning

confidence: 99%

Pediatric kidney transplantation in Egypt: Results of 10‐year single‐center experience

Fadel

Bazaraa

Badawy

et al. 2020

Pediatric Transplantation

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“…In a similar study conducted in Tehran, 86% [19] of the patients required transplantation and mainly had hemodialysis. In a study done in Egypt, 93.5% [20] of patients with ESRD were undergoing hemodialysis. In another research conducted in China, 15.8% of patients needed alternative treatment, of which 66.5% were under dialysis [17].…”

Section: Discussionmentioning

confidence: 99%

Demographic Characteristics of Patients and Causes Leading to Chronic Renal Failure in Children Admitted to Mashhad Children Hospital

Azarfar¹,

Esmaeeli²,

Ravanshad³

et al. 2017

OJNeph

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Background: An irreversible renal function impairment is called chronic renal failure (CRF) which finally leads to the "end-stage renal disease" (ESRD) and requires renal replacement therapies. The aim of this study is to evaluate the incidence, prevalence of epidemiological indicators (age, sex), and causes of chronic renal failure in children in Mashhad (one of the big cities of Iran). Methods: This is a cross-sectional study that was conducted on patients' records over a seven-year period (2008-2014) in Doctor Sheikh Children's Hospital of Mashhad. The inclusion criteria were all children under 20 years old diagnosed with ESRD, with a GFR less than 15 ml/min/1.73 m 2 who were referred to the hospital during the study period. Patients' information, such as age, gender, onset of dialysis, causes of constructing renal failure, and positive or negative antigen of hepatitis B was extracted from their records. Data were analyzed using SPSS 16 software. Results: A total of 326 patients were studied, of which, 56.4% were male. 45.1% were from 7 to 18 years. 56.4% of patients were on hemodialysis and others were on peritoneal dialysis. The most common cause of chronic renal failure in the study was respectively reflux nephropathy (32.9%), nephrotic syndrome (8.9%), neurogenic bladder (5.5%), stones (2.5%), glomerulopathy (2.1%) and cystinosis (1.5%) and (20.9%) had unknown cause. During the 7-year period of study considering the treatment outcomes, 69.3% of patients needed to continue the dialysis; 10.4% underwent transplantation; 10.4% unfortunately died despite of treatment and 1.5% were cured. Conclusions: It

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“…Studies conducted by Safouh H., et al (19) and Staples A.O., et al (20) revealed that the most common diagnosis was obstructive uropathy. In addition, Olowu W.A., et al (21) revealed in a study conducted in Nigeria that the most common etiology of CKD among the studied population was glomerular disease and in a study conducted by Cerón A., et al (22) , the most frequent presentation was chronic renal failure.…”

Section: Discussionmentioning

confidence: 99%