Causes of Clonal Hematopoiesis: a Review

Clonal hematopoiesis and COVID‐19 hospitalization in Danish adults

“…Clonal hematopoiesis of indeterminate potential (CHIP) refers to the nonmalignant clonal expansion of blood stem cells that carry somatic mutations in myeloid cancer‐associated genes 1 . The main driver of CHIP progression is age, but other factors like smoking or chemotherapy exposure can also have significant effects 2 . CHIP has been associated with an increased risk of hematological malignancies and a range of other age‐related conditions, including severe infections and death 1,3 .…”

“… 1 The main driver of CHIP progression is age, but other factors like smoking or chemotherapy exposure can also have significant effects. 2 CHIP has been associated with an increased risk of hematological malignancies and a range of other age‐related conditions, including severe infections and death. 1 , 3 The basis for this link is suggested to be an altered inflammatory response, which could occur as a result of mutations that impair the regulation of proinflammatory factor secretion from myeloid cells.…”