Causes of Death Among 379 Patients With Hemophilia: A Developing Country’s Report

Abstract

There are steps to achieve an optimum life for patients with hemophilia in developing countries, and awareness of the pattern of death in patients with hemophilia is a prerequisite for any health-care program. Owing to the lack of any data on the pattern of death in patients with hemophilia from developing countries, the current study was done to address common causes of death, and the spectrum of causes of death among individuals with hemophilia A and B. To address the pattern of death in northeast of Iran, we retrospectively collected demographic data regarding deceased patients with hemophilia A and B. Overall, among 379 people with hemophilia A and B, there were 46 deaths. Thirty-two deaths happened in the severe forms of the diseases. The obtained results show the patterns of death in the patients studied are not as parallel as some reports from the developed countries. Traumatic and spontaneous bleeding events were the main causes of death. The trend of death shows a decrease in the current decade post better therapeutic facilities. Evaluation of causes of death in hemophilia can be a useful indicator for managing the efficacy of health care in the current patients.

Mortality of patients with haemophilia in Brazil: First report

“…This is reflected by nearly normal life expectancies of patients with haemophilia reported in developed countries, especially when patients infected with HIV are excluded from analysis . However, studies in low‐ and middle‐income countries are scarce, and therefore, mortality and its causes are virtually unknown in these populations.…”

“…Despite the technological progress, mortality of patients with haemophilia is still higher than that of the general male population in different countries as United States, The Netherlands and United Kingdom . However, studies investigating the mortality of haemophilia patients in developing countries are scarce . To our concern, mortality in patients with haemophilia in Latin America has not been published.…”

“…especially when patients infected with HIV are excluded from analysis 4,15. However, studies in low-and middle-income countries are scarce,6,7 and therefore, mortality and its causes are virtually unknown in these populations.In 2006, the mortality of patients with haemophilia in the Netherlands (1992-2001) was 2.3 higher in comparison with the general male population (SMR 2.3; 95% CI: 1.9-2.8) 4. When patients with HIV were excluded, the analysis showed a lower SMR of 1.95% CI: 1.3-2.7].…”

Bone Density Status in Bleeding Disorders: Where Are We and What Needs to Be Done?

“…The spectrum of bleeding manifestations varies from superficial ecchymosis to lethal hemorrhage in central nervous system. [ 1 2 ]…”

Is It Rational to Study Coagulations Test Routinely before Operations and Invasive Procedure: Single Center Retrospective Study

“…Recently, we retrospectively reviewed causes of death among patients with hemophilia in our region 3 . In that survey, there were cases who had died or encounter serious problems after circumcision or other surgeries.…”