“…Conventional echocardiographic parameters such as left ventricular (LV) end‐diastolic/end‐systolic volume and LV ejection fraction (LVEF) are considered reliable indicators to identify the outcome and risk of cardiovascular events in a wide range of clinical settings 2,3 . Despite the fact that LVEF derived from 2D calculation according to the modified Simpson method has long been considered as the most sensitive parameter of LV systolic function with high prognostic value, it has a number of inherent limitations that significantly reduce its capacity to show real LV performance.…”