Causes of Death in Patients with Peptic Ulcer Perforation: A Long-Term Follow-up Study

Abstract

Increased mortality in ulcer perforation patients could mainly be attributed to smoking-related diseases. This is indirect evidence that smoking may be an important aetiologic factor for ulcer perforation.

Long‐Term Mortality in Patients Operated for Perforated Peptic Ulcer: Factors Limiting Longevity are Dominated by Older Age, Comorbidity Burden and Severe Postoperative Complications

“…Smoking was found to be strongly associated with longterm mortality, mainly due to smoking-related illnesses measured by the excessive standard mortality ratio in a previous study [6]. In the present study, smoking was not found to be significantly associated with long-term mortality in the univariate analysis.…”

“…The presence of active cancer has been associated with both short‐ and long‐term mortality in patients with PPU. Indeed, the comprehensive study by Svanes et al [6] demonstrated that most causes of death in the long term were related to smoking‐associated diseases, including a high rate of cancer‐related deaths. In a more recent German study [8], age and the presence of comorbidities were also found to be risk factors for long‐term mortality.…”

“…Recent population‐based studies [4, 5] have reported a 30‐day mortality rate between 16 and 27 % for patients surgically treated for PPU. In contrast to short‐term mortality, only a few studies, some of which are clearly dated, have reported the long‐term mortality for this particular group of patients [6–8].…”

Duration of Survival after Peptic Ulcer Perforation

“…The study of Svanes et al [12] assesses the causes of death in long‐term follow‐up in patients treated for peptic ulcer perforation. Ulcer perforation patients experienced increased mortality from neoplasms, lung cancer, circulatory diseases, ischemic heart disease, and respiratory diseases.…”