Causes of death in the Taabo health and demographic surveillance system, Côte d'Ivoire, from 2009 to 2011

Koné, Siaka; Fürst, Thomas; Jaeger, Fabienne N.; Esso, Emmanuel; Baikoro, Nahoua; Kouadio, Kouamé A.; Adiossan, Lukas G.; Zouzou, Fabien; Boti, Louis I; Tanner, Marcel; Utzinger, Jürg; Bonfoh, Bassirou; Dao, Daouda; N’Goran, Eliézer K.

doi:10.3402/gha.v8.27271

Cited by 26 publications

(43 citation statements)

References 24 publications

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“…We provide evidence and demonstrate the endemicity of these different bacteria in the studied regions that have the same characteristics agro-ecological and climatic. Furthermore, these diseases could be a cause of death of unknown origin in rural areas in Côte d'Ivoire [ 77 ].…”

Section: Discussionmentioning

confidence: 99%

Multiple Pathogens Including Potential New Species in Tick Vectors in Côte d’Ivoire

et al. 2016

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BackgroundOur study aimed to assess the presence of different pathogens in ticks collected in two regions in Côte d’Ivoire.Methodology/Principal FindingsReal-time PCR and standard PCR assays coupled to sequencing were used. Three hundred and seventy eight (378) ticks (170 Amblyomma variegatum, 161 Rhipicepalus microplus, 3 Rhipicephalus senegalensis, 27 Hyalomma truncatum, 16 Hyalomma marginatum rufipes, and 1 Hyalomma impressum) were identified and analyzed. We identified as pathogenic bacteria, Rickettsia africae in Am. variegatum (90%), Rh. microplus (10%) and Hyalomma spp. (9%), Rickettsia aeschlimannii in Hyalomma spp. (23%), Rickettsia massiliae in Rh. senegalensis (33%) as well as Coxiella burnetii in 0.2%, Borrelia sp. in 0.2%, Anaplasma centrale in 0.2%, Anaplasma marginale in 0.5%, and Ehrlichia ruminantium in 0.5% of all ticks. Potential new species of Borrelia, Anaplasma, and Wolbachia were detected. Candidatus Borrelia africana and Candidatus Borrelia ivorensis (detected in three ticks) are phylogenetically distant from both the relapsing fever group and Lyme disease group borreliae; both were detected in Am. variegatum. Four new genotypes of bacteria from the Anaplasmataceae family were identified, namely Candidatus Anaplasma ivorensis (detected in three ticks), Candidatus Ehrlichia urmitei (in nine ticks), Candidatus Ehrlichia rustica (in four ticks), and Candidatus Wolbachia ivorensis (in one tick).Conclusions/SignificanceFor the first time, we demonstrate the presence of different pathogens such as R. aeschlimannii, C. burnetii, Borrelia sp., A. centrale, A. marginale, and E. ruminantium in ticks in Côte d’Ivoire as well as potential new species of unknown pathogenicity.

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Section: Discussionmentioning

confidence: 99%

Multiple Pathogens Including Potential New Species in Tick Vectors in Côte d’Ivoire

et al. 2016

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“…The aim of the present study was to assess the local epidemiology of malaria in the Taabo health and demographic surveillance system (HDSS) of south-central Côte d’Ivoire [ 9 ]. An in-depth analysis of 712 deaths recorded in the Taabo HDSS between 2009 and 2011 revealed that malaria was the most important cause of death (n = 129, 18.0 %) [ 10 ]. Here, results from two cross-sectional surveys conducted in the rainy season of 2010 and 2011 are reported.…”

Section: Introductionmentioning

confidence: 99%

Epidemiology of malaria in the Taabo health and demographic surveillance system, south-central Côte d’Ivoire

Bassa

Ouattara

Silué

et al. 2016

Malar J

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Background A deep understanding of the local epidemiology of malaria is essential for the design and implementation of setting-specific control and elimination efforts. In Côte d’Ivoire, new initiatives are underway to reduce the burden of malaria, which requires high-quality longitudinal data. The epidemiology of malaria was studied in the Taabo health and demographic surveillance system (HDSS) in south-central Côte d’Ivoire and implications for control are discussed.MethodsTwo cross-sectional surveys were carried out in the rainy season of June/July in 2010 and 2011. Inhabitants of approximately 7 % of randomly selected households in the Taabo HDSS were invited to participate. People were clinically examined, ear temperature was measured and spleen size determined. Finger-prick blood samples were collected and subjected to a rapid diagnostic test (RDT). Additionally, thick and thin blood films were prepared on microscope slides and diagnosed under a microscope for Plasmodium infection and parasitaemia. Haemoglobin (Hb) level was determined using a HemoCue device.ResultsA total of 1187 and 1264 people in 2010 and 2011, respectively, had complete data records. The prevalence of Plasmodium infection was 46.0 % in 2010 and 56.6 % in 2011, owing to a statistically significant difference (p < 0.05). Males showed a higher Plasmodium infection prevalence than females (49.6 and 62.8 % versus 42.6 and 51.2 %; respectively, in 2010 and 2011; both p < 0.05). The highest malaria prevalence was observed among infants and young children (aged ≤9 years). The risk of Plasmodium infection was significantly higher in villages compared to small hamlets and urban settings (p < 0.05). Fever, Hb level and splenomegaly were associated with parasitaemia.ConclusionMalaria is highly endemic in the Taabo HDSS in south-central Côte d’Ivoire with considerable spatial heterogeneity of Plasmodium infection. There is a pressing need to scale-up control interventions against malaria.

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“…This 9-month cluster-randomised, single-blinded, placebo-controlled intervention trial was conducted in the Taabo health and demographic surveillance system (HDSS) in south-central Côte d’Ivoire [ 10 ]. Recently it has been reported that the leading causes of death among children below 5 years of age in the Taabo HDSS are malaria, followed by acute respiratory tract infections and HIV/AIDS [ 11 ]. Malaria transmission is perennial with peaks occurring in the large rainy season (from April to August) and in the small rainy season (September/October).…”

Section: Methodsmentioning

confidence: 99%

The effect of iron-fortified complementary food and intermittent preventive treatment of malaria on anaemia in 12- to 36-month-old children: a cluster-randomised controlled trial

Glinz¹,

Hurrell²,

Ouattara

et al. 2015

Malar J

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BackgroundIron deficiency (ID) and malaria co-exist in tropical regions and both contribute to high rates of anaemia in young children. It is unclear whether iron fortification combined with intermittent preventive treatment (IPT) of malaria would be an efficacious strategy for reducing anaemia in young children.MethodsA 9-month cluster-randomised, single-blinded, placebo-controlled intervention trial was carried out in children aged 12–36 months in south-central Côte d’Ivoire, an area of intense and perennial malaria transmission. The study groups were: group 1: normal diet and IPT-placebo (n = 125); group 2: consumption of porridge, an iron-fortified complementary food (CF) with optimised composition providing 2 mg iron as NaFeEDTA and 3.8 mg iron as ferrous fumarate 6 days per week (CF-FeFum) and IPT-placebo (n = 126); group 3: IPT of malaria at 3-month intervals, using sulfadoxine-pyrimethamine and amodiaquine and no dietary intervention (n = 127); group 4: both CF-FeFum and IPT (n = 124); and group 5: consumption of porridge, an iron-fortified CF with the composition currently on the Ivorian market providing 2 mg iron as NaFeEDTA and 3.8 mg iron as ferric pyrophosphate 6 days per week (CF-FePP) and IPT-placebo (n = 127). The primary outcome was haemoglobin (Hb) concentration. Linear and logistic regression mixed-effect models were used for the comparison of the five study groups, and a 2 × 2 factorial analysis was used to assess treatment interactions of CF-FeFum and IPT (study groups 1–4).ResultsAfter 9 months, the Hb concentration increased in all groups to a similar extent with no statistically significant difference between groups. In the 2 × 2 factorial analysis after 9 months, no treatment interaction was found on Hb (P = 0.89). The adjusted differences in Hb were 0.24 g/dl (95 % CI −0.10 to 0.59; P = 0.16) in children receiving IPT and −0.08 g/dl (95 % CI −0.42 to 0.26; P = 0.65) in children receiving CF-FeFum. At baseline, anaemia (Hb <11.0 g/dl) was 82.1 %. After 9 months, IPT decreased the odds of anaemia (odds ratio [OR], 0.46 [95 % CI 0.23–0.91]; P = 0.023), whereas iron-fortified CF did not (OR, 0.85 [95 % CI 0.43–1.68]; P = 0.68), although ID (plasma ferritin <30 μg/l) was decreased markedly in children receiving iron fortified CF (OR, 0.19 [95 % CI 0.09–0.40]; P < 0.001).ConclusionsIPT alone only modestly decreased anaemia, but neither IPT nor iron fortified CF significantly improved Hb concentration after 9 months. Additionally, IPT did not augment the effect of the iron fortified CF. CF fortified with highly bioavailable iron improved iron status but not Hb concentration, despite three-monthly IPT of malaria. Thus, further research is necessary to develop effective combination strategies to prevent and treat anaemia in malaria endemic regions.Trial registration: http://www.clinicaltrials.gov; identifier NCT01634945; registered on July 3, 2012.Electronic supplementary materialThe online version of this article (doi:10.1186/s12936-015-0872-3) contains supplementary material, which is available...

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Causes of death in the Taabo health and demographic surveillance system, Côte d'Ivoire, from 2009 to 2011

Cited by 26 publications

References 24 publications

Multiple Pathogens Including Potential New Species in Tick Vectors in Côte d’Ivoire

Multiple Pathogens Including Potential New Species in Tick Vectors in Côte d’Ivoire

Epidemiology of malaria in the Taabo health and demographic surveillance system, south-central Côte d’Ivoire

The effect of iron-fortified complementary food and intermittent preventive treatment of malaria on anaemia in 12- to 36-month-old children: a cluster-randomised controlled trial

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