Causes of Fetal Wastage

Simpson, Joe Leigh

doi:10.1097/grf.0b013e31802f11f6

Cited by 100 publications

(80 citation statements)

References 129 publications

(100 reference statements)

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“…First-trimester miscarriage is the most common complication of human reproduction with an incidence that ranges between 50% and 70% of all conceptions [1]. Aneuploidy is found in the majority of first-trimester miscarriages.…”

Section: Discussionmentioning

confidence: 99%

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Comparison of chromosomal abnormality rates in ICSI for non-male factor and spontaneous conception

Bingöl

Abıke

Gedikbaşı³

et al. 2011

J Assist Reprod Genet

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Objective To compare cytogenetic data of first-trimester missed abortions in intracytoplasmic sperm injection (ICSI) for non-male factor-mediated and spontaneous pregnancies. Methods Using karyotype analysis, we conducted a retrospective cohort trial of missed abortions following ICSI for non-male factor and spontaneous pregnancies. Patients experienced missed abortions during the first 12 weeks of pregnancy. Dilation and curettage procedure was performed followed by cytogenetic evaluations. Two patient groups were created: ICSI (n=71) and spontaneous pregnancies (n= 81). At least 20 GTG-banded metaphases were analyzed in each case for cytogenetic analyses. Statistical analyses were performed using NCSS 2007 Statistical Program software. The significance level and confidence interval for all analyses were set to p<0.05 and a 95% confidence interval, respectively. Results A total of 49.3% (75/152) of the miscarriages were cytogenetically abnormal among the patients. We detected cytogenetically abnormalities in 47.9% (34/71) of the ICSI group and 50.6% (41/81) of the control group, which were not statistically significant differences (p=NS). The sex chromosome abnormalities were similar between the ICSI and control groups (p=NS). The most prevalent abnormalStatement for authors submitting original research: The responsible authors at the institute where the work has been carried out have approved the enclosed manuscript "Comparison of Chromosomal Abnormality Rates in ICSI for Non-Male Factor and Spontaneous Conception". Authors certify that none of the materials in this manuscript has been published previously in any form and that none of this material is currently under consideration for publication elsewhere. All authors have participated sufficiently in the intellectual content, the analysis of data and the writing the manuscript to take public responsibility for it.Capsule The chromosomal anomalies and aneuploidy rates following ICSI for non-male factor were similar to those following natural conception. Assist Reprod Genet (2012) 29:25-30 DOI 10.1007 ities that were observed in the ICSI and control groups with first-trimester pregnancy loss were trisomy (n=42; 27.6%), Turner syndrome (45, X0, n=13; 8.6%), triploidy (n=13; 8.6%), 48 chromosomes (n=5; 3.3%), and mixed chromosomal abnormalities (n=3; 1.2%). In addition, the karyotypes were similar between the ICSI and control groups (p=NS). We observed increases in fetal aneuploidy rates with increased maternal age (<30 years=23.9% vs. 31-34 years=37.0% vs. 35-39 years=82.9% vs. >39 years= 90.9%). However, the observed increases in fetal aneuploidy rates were not statistically significant (p=NS). Conclusion The aneuploidy rates and sex chromosome anomalies following ICSI for non-male factor were similar to those following natural conception.

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Section: Discussionmentioning

confidence: 99%

“…First-trimester miscarriage is the most common complication of human reproduction with an incidence ranging between 50% and 70% of all conceptions [1]. Genetic defects, especially chromosomal abnormalities, are the most common causes of spontaneous miscarriage during the first trimester.…”

Section: Introductionmentioning

confidence: 99%

Comparison of chromosomal abnormality rates in ICSI for non-male factor and spontaneous conception

Bingöl

Abıke

Gedikbaşı³

et al. 2011

J Assist Reprod Genet

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“…Although 50-80% of miscarriages in the first trimester are due to ''sporadic'' chromosomal mutation [Simpson, 2007], application of genomic methods might show that gene mutation and copy-number variation also play an important role; and epidemiology studies involving genomic analyses might show that these genetic events are less ''sporadic'' and actually associated with environmental exposures. We may soon be able to determine the potential harm from an agent not just to those who are exposed to that agent, but to their unexposed descendents.…”

Section: Need For a Declaration Panel And Implications Of Declaring Amentioning

confidence: 99%

Declaring the existence of human germ‐cell mutagens

DeMarini

2012

Environ and Mol Mutagen

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After more than 80 years of searching for human germ‐cell mutagens, I think that sufficient evidence already exists for a number of agents to be so considered, and definitive confirmation seems imminent due to the application of recently developed genomic techniques. In preparation for this, an assessment panel of internationally recognized experts in germ‐cell biology and genomics is required to consider either the current evidence now, or impending genomic evidence later, to declare whether an agent is a human germ‐cell mutagen. I propose that such a panel be organized under the aegis of the World Health Organization and constructed similarly to the working groups assembled by the International Agency for Research on Cancer for the evaluation of human carcinogens. Support from prominent national and international organizations would be important. Many regulatory agencies already have procedures in place for assessing potential human germ‐cell mutagens, and the time is approaching when definitive genomic data in humans will obligate such evaluations. In my view, application of an IARC‐type of assessment using available evidence leads to the conclusion that ionizing radiation, cancer chemotherapy, cigarette smoking, and air pollution are “Group 1” human germ‐cell mutagens. Consideration of the potential adverse health effects to the unexposed offspring of an exposed parent will usher in an entirely new realm of environmental health assessment. I suggest that the long search for human germ‐cell mutagens is about to end, and a demonstration of the much‐anticipated linkage between heritable disease and environmental factors is poised to begin. Environ. Mol. Mutagen. 2012. © 2012 Wiley Periodicals, Inc.

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“…Aneuploidy is found in the majority of first trimester miscarriages; multiple cytogenetic studies have demonstrated aneuploidy rates ranging from 50% to 80% in various populations [1][2][3][4]. Autosomal trisomies are the most frequent karyotypic abnormalities; however, polyploidies, sex chromosome monosomies, and structural rearrangements account for a substantial number of miscarriages [2]. Several studies have demonstrated increasing miscarriage and aneuploidy rates with increasing maternal age [5][6][7].…”

Section: Introductionmentioning

confidence: 99%

Aneuploidy in abortuses following IVF and ICSI

Kushnir

Frattarelli

2009

J Assist Reprod Genet

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Purpose To compare aneuploidy rates in first trimester pregnancy losses following IVF ± ICSI. Methods A retrospective cohort analysis of karyotypes of abortuses following conventional IVF (n = 159) and ICSI (n = 196). Results 50.1% of losses were found to be cytogenetically abnormal among all patients undergoing IVF ± ICSI. A significant increase in fetal aneuploidy rate was noted with increasing maternal age (<30 years = 26.1% vs. 31 to 34 years. = 38.2% vs. 35 to 39 years. = 51.3% vs. >39 years. = 65.9%). Aneuploidy rates were similar in the ICSI vs. conventional IVF groups (52.6% vs. 47.2% [p 0.31, RR 1.11, 95% CI 0.90, 1.38]). More sex chromosome anomalies were noted in the ICSI group. Conclusions The aneuploidy rate in first trimester abortuses significantly increases with increasing maternal age. ICSI was not shown to significantly increase the aneuploidy rate.However, more sex chromosome anomalies were found among pregnancies resulting from ICSI.

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Causes of Fetal Wastage

Cited by 100 publications

References 129 publications

Comparison of chromosomal abnormality rates in ICSI for non-male factor and spontaneous conception

Comparison of chromosomal abnormality rates in ICSI for non-male factor and spontaneous conception

Declaring the existence of human germ‐cell mutagens

Aneuploidy in abortuses following IVF and ICSI

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