Causes of Maternal Mortality in Japan

Nagaya, Ken

doi:10.1001/jama.283.20.2661

Cited by 87 publications

(52 citation statements)

References 9 publications

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“…The results of the study corresponds to those of the studies conducted by Montazeri et al (2008) in Kermanshah and Najaya et al (2000) in Japan [18] [19]. In the present study, concerning the hospital where delivery is done, X 2 test showed that there is a significant difference between the two groups, control and subject group.…”

Section: Discussionsupporting

confidence: 90%

Assessing Demographic Factors Related to Maternal Mortality in Tehran Province, Iran from 2008 to 2011

Farzianpour¹,

Foroushani²,

Changizi³

et al. 2015

Health

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The rate of maternal mortality due to complications of pregnancy and delivery is one of the most significant indicators showing the development state of countries. The purpose of the present study is to assess important indicators of maternal health and predisposing factors of maternal mortality in Tehran province from 2008 to 2011. The present study is a case-control one. All mothers who had lost their life (n = 113) were selected through census and survived mothers (n = 327) through randomized stratified sampling. Statistical analysis was performed using SPSS V.22, X 2 test, Fishers exact test and Logistic regression. The rate of maternal mortality was the highest (29.2%) in 2009 and the lowest (20.4%) in 2011. Variables type of maternity hospital (P-value = 0.036), maternal education (P-value < 0.001), husband's education (P-value < 0.001) had a significant relation to maternal mortality. Logistic regression analysis showed that there is a relationship between the education level of the husband and maternal mortality. Considering the factors affecting maternal mortality, promoting hospital services, improving skills and knowledge of doctors, midwives and nurses and strengthening educational programs for the illiterate are the most effective measures to reduce maternal mortality.

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Section: Discussionsupporting

confidence: 90%

Assessing Demographic Factors Related to Maternal Mortality in Tehran Province, Iran from 2008 to 2011

Farzianpour¹,

Foroushani²,

Changizi³

et al. 2015

Health

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“…It occurs in about 2.5% of pregnant Japanese women (1) and results in substantial maternal and neonatal morbidity and mortality (2,3). Although some types of gene polymorphisms are associated with the occurrence of preeclampsia (4)(5)(6), the pathophysiology of preeclampsia remains uncertain despite significant research efforts.…”

Section: Introductionmentioning

confidence: 99%

Alteration of Serum Soluble Endoglin Levels after the Onset of Preeclampsia Is More Pronounced in Women with Early-Onset

et al. 2008

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It has been established that serum soluble endoglin (sEng) increases in women with preeclampsia. However, sEng levels have not been evaluated using a normal reference value specific to each gestational age.First, we established the normal reference value for sEng using 85 pregnant controls without preeclampsia, from whom serum samples were collected three times at 20-23, 27-30, and 36-38 weeks of gestation. Second, we evaluated the serum sEng levels after the onset of preeclampsia in 56 preeclamptic patients. In three women (3.5%) with normal pregnancies, sustained high sEng levels (>15 ng/mL) were observed. We

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“…Preeclampsia (pregnancy induced hypertension with proteinuria) is associated with maternal and infantile morbidity and mortality (1,2). The Japan Society for the Study of Hypertension in Pregnancy (JSSHP) classifies preeclampsia into early and late onset type according to whether the clinical manifestations occur before or after 32 weeks of gestation, respectively (3).…”

Section: Introductionmentioning

confidence: 99%

Alterations in Placental Growth Factor Levels before and after the Onset of Preeclampsia Are More Pronounced in Women with Early Onset Severe Preeclampsia

et al. 2007

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It has been established that the serum placental growth factor (PlGF) decreases and the soluble fms-like tyrosine kinase-1 (sFlt-1) increases in women with preeclampsia. However, there have been no studies on the relation between preeclampsia onset time and the changes in PlGF and sFlt-1. Furthermore, the PlGF and sFlt-1 levels have not been evaluated using their reference values specific to each gestational age. In this study we reevaluated the serum PlGF and sFlt-1 levels before and after the clinical manifestation of early and late onset severe preeclampsia using the new reference values developed in our recent longitudinal study. Blood specimens were obtained immediately after the clinical manifestation of severe preeclampsia in 34 referred women, and both before and after the clinical manifestation in 8 women receiving a routine checkup at our institute. Both women with early and those with late preeclampsia showed decreased PlGF and increased sFlt-1 levels compared to normotensive controls at 28 and 37 weeks (n =68). However, those with early onset preeclampsia had a higher incidence of low PlGF (<5th percentile on the reference values) and high sFlt-1 ( ≥ 95th percentile) than those with late onset (low PlGF: 93% vs. 55%; high sFlt-1: 100% vs. 60%). log10PlGF (r =0.574, p <0.001) and log10(sFlt-1/PlGF) (r =-0.556, p <0.001) were correlated with the week of onset of preeclampsia. Before the onset of preeclampsia, the incidence rate of low PlGF in the women with early onset preeclampsia was 100% (5/5), whereas that in the women with late onset preeclampsia was 0% (0/2) (p =0.048). Therefore, alterations in the PlGF levels both before and after the onset of preeclampsia may be more pronounced in women with early onset than those with late onset severe

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Causes of Maternal Mortality in Japan

Abstract: Inadequate obstetric services are associated with maternal mortality in Japan. Reducing single-obstetrician only delivery patterns and establishing regional 24-hour inpatient obstetrics facilities for high-risk cases may reduce maternal mortality in Japan. JAMA. 2000;283:2661-2667.

Cited by 87 publications

References 9 publications

Assessing Demographic Factors Related to Maternal Mortality in Tehran Province, Iran from 2008 to 2011

Assessing Demographic Factors Related to Maternal Mortality in Tehran Province, Iran from 2008 to 2011

Alteration of Serum Soluble Endoglin Levels after the Onset of Preeclampsia Is More Pronounced in Women with Early-Onset

Alterations in Placental Growth Factor Levels before and after the Onset of Preeclampsia Are More Pronounced in Women with Early Onset Severe Preeclampsia

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