Caveats in the diagnosis of suspected non‐endemic verrucous carcinoma in the urinary bladder

Leunbach, Tina Lund; Stilling, Christina; Tabor, Mariola Barbara; Jensen, Jørgen Bjerggaard

doi:10.1111/bju.15715

Cited by 1 publication

(1 citation statement)

References 5 publications

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“…The term "verrucous squamous cell carcinoma" was first used in 1948 by Ackerman to describe a type of well-differentiated squamous cell carcinoma of the oral cavity. 35 It has been reported in various sites, including the foot, 36,37 head, neck, [38][39][40] urinary bladder, 41 and female genital tract. [42][43][44] Verrucous carcinoma of the esophagus was first described by Minielly et al in 1967.…”

Section: Verrucous Squamous Cell Carcinomamentioning

confidence: 99%

Histomorphology and Molecular Profiling of Well-Differentiated Squamous Cell Carcinoma of the Esophagus Including its Unusual Variants

Yin¹,

Wang²,

Amofa-Ho³

et al. 2022

J Clin Transl Pathol

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Esophageal verrucous squamous cell carcinoma and esophageal carcinoma cuniculatum are rare variants of extremely well-differentiated squamous cell carcinoma. These rare tumors share similar risk factors and clinical presentations with conventional esophageal squamous cell carcinoma. However, these tumors have distinct morphological features, molecular mutation profiles, and clinical outcomes. Diagnosis of esophageal verrucous squamous cell carcinoma and esophageal carcinoma cuniculatum can be challenging, requires high clinical suspicion, and often can only be diagnosed on a deep mucosal biopsy or resection specimen. Surgical treatment or endoscopic resection can be curative in early disease. This review presents the histomorphology and molecular profiling of the conventional type and the rare variants of the esophageal well-differentiated squamous cell carcinoma.

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